Results 161 to 168 of about 1,582 (168)

Effect of 6R-l-erythro-5,6,7,8-tetrahydrobiopterin on the extracellular levels of dopamine and serotonin in the rat striatum: a microdialysis study with tyrosine or tryptophan infusion

Brain Research, 1994
The present study demonstrates the effects of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (6R-BH4) on turnover of dopamine and serotonin (5-HT) in rat striatum during continuous infusion of the amino acids tyrosine and tryptophan. By monitoring with microdialysis, it was found that the increase in dopamine and homovanillic acid (HVA) concentrations in rat
H, Tsukada, K J, Lindner, P, Hartvig, B, Långström   +3 more
openaire   +2 more sources

Enhancement of in Vivo Dopamine Release from the Rat Striatum by 6R-L-Erythro-5,6,7,8-Tetrahydrobiopterin as Studied by Brain Dialysis

1990
6R-L-erythro-5,6,7,8-Tetrahydrobiopterin (6R-BH4) is a natural cofactor for tyrosine hydroxylase, a rate-limiting enzyme for biosynthesis of catecholamines (Nagatsu et al., 1964). Since the concentration of 6R-BH4 in the brain (Fukushima and Nixon, 1980) is low compared with Km values of tyrosine hydroxylase (Nelson and Kaufman, 1987), tissue levels of
Kunio Koshimura, Soichi Miwa, Ken Lee, Motohatsu Fujiwara, Yasuyoshi Watanabe   +4 more
openaire   +1 more source

ChemInform Abstract: A Practical Synthesis of (6R)‐ and (6S)‐5,6,7,8‐Tetrahydrobiopterins

ChemInform, 1987
S. MATSUURA, T. SUGIMOTO, S. MURATA
openaire   +1 more source

The (6R) 5,6,7,8 tetrahydrobiopterin/6-biopterin redox cycle controls melanogenesis and viability in human melanocytes

Melanoma Research, 1994
K. U. Schallreuter, J. M. Wood, G. Büttner, M. R. Pittelkow, C. Koerner   +4 more
openaire   +1 more source

A novel action of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin, a cofactor for hydroxylases of phenylalanine, tyrosine and tryptophan: enhancement of acetylcholine release in vivo in the rat hippocampus.

Neuroscience letters, 1991
Recently, we have reported that 6R-L-erythro-tetrahydrobiopterin (6R-BH4), a natural cofactor for hydroxylases of phenylalanine, tyrosine and tryptophan, has a dopamine releasing action in the rat striatum independent of its cofactor role. Here we studied the effects of 6R-BH4 on acetylcholine (ACh) release in the rat hippocampus using brain ...
T, Ohue, K, Koshimura, K, Lee, Y, Watanabe, S, Miwa   +4 more
openaire   +1 more source

A Practical Synthesis of (6R)- and (6S)-5,6,7,8-Tetrahydrobiopterins

1986
Sadao Matsuura, Takashi Sugimoto, Shizuaki Murata   +2 more
openaire   +1 more source

1402 6R- l-Erythro-5,6,7,8-tetrahydrobiopterin modulates the receptor binding of the monoaminergic systems in the rat visual pathway

Neuroscience Research, 1996
Keiko Muguruma, Kazuyuki Imamura, Yasuyoshi Watanabe   +2 more
openaire   +1 more source

Direct dopamine releasing action of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin, a cofactor for tyrosine hydroxylase. II. Comparison with the effects of other pteridines

Neuroscience Research Supplements, 1991
Kunio Koshimura, Ken Lee, Tetsuya Ohue, Yasuyoshi Watanabe, Soichi Miwa   +4 more
openaire   +1 more source