Results 61 to 70 of about 1,582 (168)

Progress and Application of Multifunctional Hydrogel in Radioactive Skin Injury

Advanced Materials Interfaces, Volume 12, Issue 11, June 9, 2025.
This review examines healing challenges in radiation‐wound injuries, where ionizing radiation impairs immune and tissue repair processes. Hydrogels, with their biocompatibility, antimicrobial properties, and drug delivery capabilities, present a transformative solution. It compares hydrogel efficacy in radiation‐induced versus common wounds, highlights
Xinyue Cui, Jingyi Wang, Xinyi Xu, Xiqian Cao, Yingtang Zhou, Jiaming Guo   +5 more
wiley   +1 more source

Substituting Tyr138 in the active site loop of human phenylalanine hydroxylase affects catalysis and substrate activation

FEBS Open Bio, Volume 7, Issue 7, Page 1026-1036, July 2017., 2017
The conformation and function of mammalian phenylalanine hydroxylase is triggered by binding of its substrate, and regional motion of the Tyr138‐loop is a key element in this process. Mutagenesis of Tyr138 reported here, together with previous crystallographic‐structural modeling, infers that the functional information obtained about the Tyr138‐loop in
João Leandro, Anne J. Stokka, Knut Teigen, Ole A. Andersen, Torgeir Flatmark   +4 more
wiley   +1 more source

Immune activation and inflammation in patients with cardiovascular disease are associated with elevated phenylalanine-to-tyrosine ratios

Pteridines, 2013
Higher serum neopterin concentrations and kynurenine-to-tryptophan (Kyn/Trp) ratios are associated with increased mortality in patients with coronary artery disease (CAD). Preferentially, Th1-type cytokine interferon-γ stimulates tryptophan breakdown and
Mangge Harald, Schnedl Wolfgang J., Schröcksnadel Sebastian, Geisler Simon, Murr Christian, Fuchs Dietmar   +5 more
doaj   +1 more source

Production and Peripheral Roles of 5-HTP, a Precursor of Serotonin [PDF]

, 2009
Serotonin (5-hydroxytryptamine [5-HT]) has been implicated in a variety of physiological and pathological functions. Multiple steps of enzyme reactions enable biosynthesis of 5-HT.
Hasegawa, Hiroyuki, Nakamura, Kazuhiro
core   +5 more sources

Evolutionary formation of melatonin and vitamin D in early life forms: insects take centre stage

Biological Reviews, Volume 99, Issue 5, Page 1772-1790, October 2024.
ABSTRACT Melatonin, a product of tryptophan metabolism via serotonin, is a molecule with an indole backbone that is widely produced by bacteria, unicellular eukaryotic organisms, plants, fungi and all animal taxa. Aside from its role in the regulation of circadian rhythms, it has diverse biological actions including regulation of cytoprotective ...
Tae‐Kang Kim, Radomir M. Slominski, Elzbieta Pyza, Konrad Kleszczynski, Robert C. Tuckey, Russel J. Reiter, Michael F. Holick, Andrzej T. Slominski   +7 more
wiley   +1 more source

Immune activation and inflammation increase the plasma phenylalanine-to-tyrosine ratio

Pteridines, 2013
The proinflammatory cytokine interferon (IFN) γ activates GTP-cyclohydrolase I. In turn, the production of neopterin in human monocytic cells and of 5,6,7,8-tetrahydrobiopterin (BH4) in other human cells and cells of other species is markedly upregulated.
Geisler Simon, Gostner Johanna M., Becker Kathrin, Ueberall Florian, Fuchs Dietmar   +4 more
doaj   +1 more source

Pahenu1 is a mouse model for tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency and promotes analysis of the pharmacological chaperone mechanism in vivo [PDF]

, 2017
The recent approval of sapropterin dihydrochloride, the synthetic form of 6[R]-l-erythro-5,6,7,8-tetrahydrobiopterin (BH4), for the treatment of phenylketonuria (PKU) as the first pharmacological chaperone drug initiated a paradigm change in the ...
Danecka, Marta K., Domdey, Katharina A., Eichinger, Anna, Fingerhut, Ralph, Gersting, Søren W., Glossmann, Hartmut, Kemter, Kristina F., Lagler, Florian B., Messing, Dunja D., Muntau, Ania C., Roscher, Adelbert A., Staudigl, Michael, Zsifkovits, Clemens   +12 more
core  

Tracer‐based metabolomics for profiling nitric oxide metabolites in a 3D microvessels‐on‐chip model

The FASEB Journal, Volume 38, Issue 16, 31 August 2024.
Endothelial dysfunction is characterized by diminished nitric oxide (NO) bioavailability—a key signaling molecule for vascular homeostasis. Here we developed a tracer‐based metabolomics approach to measure NO‐specific metabolites with mass spectrometry (MS) and show the impact of fluid flow on metabolic parameters associated with NO synthesis using 2D ...
Kanchana Pandian, Luojiao Huang, Abidemi Junaid, Amy Harms, Anton Jan van Zonneveld, Thomas Hankemeier   +5 more
wiley   +1 more source

Experimental structure based drug design (SBDD) applications for anti‐leishmanial drugs: A paradigm shift?

Medicinal Research Reviews, Volume 44, Issue 3, Page 1055-1120, May 2024.
Abstract Leishmaniasis is a group of neglected tropical diseases caused by at least 20 species of Leishmania protozoa, which are spread by the bite of infected sandflies. There are three main forms of the disease: cutaneous leishmaniasis (CL, the most common), visceral leishmaniasis (VL, also known as kala‐azar, the most serious), and mucocutaneous ...
Miguel Marín, Marta López, Laura Gallego‐Yerga, Raquel Álvarez, Rafael Peláez   +4 more
wiley   +1 more source

Cerebrospinal fluid neopterin: an informative biomarker of central nervous system immune activation in HIV-1 infection [PDF]

, 2010
HIV-1 invades the central nervous system (CNS) in the context of acute infection, persists thereafter in the absence of treatment, and leads to chronic intrathecal immunoactivation that can be measured by the macrophage activation marker, neopterin, in ...
Bestetti, Arabella, Brew, Bruce J, Cinque, Paola, Fuchs, Dietmar, Gisslen, Magnus, Hagberg, Lars, Price, Richard W, Spudich, Serena   +7 more
core   +4 more sources