General Psychiatry, Volume 37, Issue 1, February 2024.The gut microbiota is a complex and dynamic ecosystem known as the ‘second brain’. Composing the microbiota‐gut‐brain axis, the gut microbiota and its metabolites regulate the central nervous system through neural, endocrine and immune pathways to ensure the normal functioning of the organism, tuning individuals’ health and disease status.
Junzhe Cheng +6 more
wiley +1 more source
Pteridines, 2006 5,6,7,8-Tetrahydrobiopterin (BH4) is an csscntial cofactor for production of nitric oxide (NO) by N O synthase (NOS). Nitric oxide (NO) is an important signaling mo!ecu!e for the regulation o f vita! functions such as vascular tone, neurotransmission and
Shimizu Shunichi +4 more
doaj +1 more source
Does the pain-protective GTP cyclohydrolase haplotype significantly alter the pattern or severity of pain in humans with chronic pancreatitis? [PDF]
, 2008 Background Pain is often a dominant clinical feature of chronic pancreatitis but the frequency and severity is highly variable between subjects. We hypothesized that genetic polymorphisms contribute to variations in clinical pain patterns.
Anderson, Michelle A +6 more
core +3 more sources
Pteridines, 2000 Impairment of lipid metabolism due to excess metabolite accumulation induced by pyridoxal-5-phosphate (P-5-P)-deficiency and/or stimulated immune system has been studied and interpreted.
Rudzite Vera +3 more
doaj +1 more source
Inhibition of L-Arginine Metabolizing Enzymes by L-Arginine-Derived Advanced Glycation End Products [PDF]
, 2010 Nω-Carboxymethyl-arginine (CMA), Nω-carboxyethyl-arginine (CEA) and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) have been identified as L-arginine-derived advanced glycation end products (AGEs) formed by non-enzymatic reactions between ...
Aoyama, Sae +4 more
core +2 more sources
Studies on the regulation of endothelial nitric oxide synthase in endothelial dysfunction [PDF]
, 2016 Ischaemic heart disease and cerebrovascular disease are the leading causes of morbidity and mortality in the world. The underlying progression of the disease is linked to a reduction in the bioavailability of nitric oxide. One factor contributing to this
Cerrato, Ruha
core +1 more source
Association of biochemical, cytokine and echocardiographic markers of cardiovascular injuries with t894g polymorphism of endothelial nitric oxide synthase gene in patients with nonviral liver cirrhosis [PDF]
, 2013 Background & Aims: Alterations of vascular endothelium play an important role in the development of cardiovascular diseases, the occurrence of liver cirrhosis and the progression of its complications.
Taras Boychuk, Vasyl Prysyazhnyuk, Olexander Voloshyn, Larysa Sydorchuk, Roman Bulyk
core
Monitoring of immune activation using biochemical changes in a porcine model of cardiac arrest. [PDF]
, 2001 In animal models, immune activation is often difficult to assess because of the limited availability of specific assays to detect cytokine activities.
Amann, A +7 more
core +3 more sources
Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate [PDF]
, 2006 The protozoan Trypanosoma brucei has a functional pteridine reductase (TbPTR1), an NADPH-dependent short-chain reductase that participates in the salvage of pterins, which are essential for parasite growth.
Alan H. Fairlamb +14 more
core +3 more sources
Salsolinol: an Unintelligible and Double-Faced Molecule—Lessons Learned from In Vivo and In Vitro Experiments [PDF]
, 2017 Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline) is a tetrahydroisoquinoline derivative whose presence in humans was first detected in the urine of Parkinsonian patients on l-DOPA (l-dihydroxyphenylalanine) medication.
Bugajski, Andrzej +3 more
core +2 more sources