A Tetrahydrobiopterin-Displacing Potent Neuronal Nitric Oxide Synthase Inhibitor with an Unprecedented Binding Mode [PDF]
Nitric oxide synthase (NOS) is a pivotal enzyme that regulates various physiological processes, and the dysregulation of neuronal NOS (nNOS) is implicated in neurodegenerative diseases.
Hardy, Christine D +5 more
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ESTABLISHING PTERIDINE METABOLISM IN A BREAST CANCER CELL MODEL AND QUANTIFICATION OF SILVER NANOPARTICLE INTERACTIONS WITH YEAST CELLS USING MASS SPECTROMETRY [PDF]
, 2022 Recent advances in analytical methods have furthered the quantitative insights that can be gleaned from cellular analyses, with applications in cancer and nanoparticle research. In the first part of the research presented, a recently developed HPLC-MS/MS
Rasmussen, Lindsey Katherine
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Simulation Study of Adrenaline Synthesis from Phenylalanine [PDF]
, 2015 Â Â Â Â Â Â Simulation study of Adrenaline synthesis from Phenylalanine has been carried out using semi-empirical methods (PM3) and density functional theory (DFT) STO-3G level of theory .
A-Ali Drea, Abbas, T. Mohammed, Halla
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Charakterisierung eines Mausmodells zur BH4-sensitiven Phenylketonurie [PDF]
, 2019 Phenylketonurie (PKU) ist eine angeborene Störung des Aminosäurestoffwechsels, die unbehandelt zu schweren neurologischen Schäden führt. In vielen Fällen ist die einzige mögliche Behandlungsoption eine streng eiweißarme Diät. Im Rahmen klinischer Studien
Eichinger, Anna
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Cloning, Expression, and Purification of a Nitric Oxide Synthase-Like Protein from Bacillus cereus [PDF]
, 2010 The nitric oxide synthase-like protein from Bacillus cereus (bcNOS) has been cloned, expressed, and characterized. This small hemeprotein (356 amino acids in length) has a mass of 43 kDa and forms a dimer.
Dupont, Andrea L. +3 more
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Transformation of 6-tetrahydrobiopterin in aqueous solutions under UV-irradiation [PDF]
, 2017 © 2017 Elsevier B.V. Melanogenesis disturbance leads to several pathologies, including vitiligo disease. Ultraviolet (UV) narrowband phototherapy (308 or 311nm) is used in treating vitiligo; however, the mechanism of phototherapy is not yet understood ...
Biryukov M. +6 more
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Genetic Modulation of Cerebral Vasculopathy in Children with Sickle Cell Anemia [PDF]
, 2018 Palestras de difusão da cultura científica dirigidas aos colaboradores internos do INSA, podendo incluir participantes externos envolvidos nos estudos e colegas de investigação da área de trabalho em questão.Sickle cell anemia (SCA) arises from ...
Coelho, Andreia +13 more
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Effects of Mitochondrial-Targeted Antioxidants on Real-Time Blood Nitric Oxide and Hydrogen Peroxide Release in Acute Hyperglycemia Rats [PDF]
, 2016 Acute hyperglycemia in non-diabetic subjects can impair vascularendothelial function, causing decreased endothelium-derived nitric oxide (NO) release and increased reactive oxygen species (ROS), such assuperoxide and hydrogen peroxide (H2O2 ...
Barsotti, Robert +5 more
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The Journal of biological chemistry, 2002 Pathological nitric oxide (NO) generation in sepsis, inflammation, and stroke may be therapeutically controlled by inhibiting NO synthases (NOS). Here we targeted the (6R)-5,6,7,8-tetrahydro-l-biopterin (H(4)Bip)-binding site of NOS, which, upon cofactor binding, maximally increases enzyme activity and NO production from substrate l-arginine. The first
P, Kotsonis +19 more
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Urinary neopterin concentrations vs total neopterins for clinical utility [PDF]
, 1989 Fuchs D, Milstien S, Krämer A, et al. Urinary neopterin concentrations vs total neopterins for clinical utility. Clinical Chemistry. 1989;35(12):2305-2307.Neopterin measurements are especially useful as an early marker in (e.g.) allograft rejections and ...
Fuchs, Dietmar +7 more
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