Results 41 to 50 of about 200 (107)

The Contribution of DNA Interstrand Crosslinks to Aging [PDF]

, 2012
DNA damage is hypothesized to be a driver of aging. In support of this, DNA damage and genetic mutations, resulting from replication of that damage, both increase in the nuclear genome as organisms age.
Robinson, Andria R
core  

Oxidative DNA Damage Modulates Trinucleotide Repeat Instability Via DNA Base Excision Repair [PDF]

, 2014
Trinucleotide repeat (TNR) expansion is the cause of more than 40 types of human neurodegenerative diseases such as Huntington’s disease. Recent studies have linked TNR expansion with oxidative DNA damage and base excision repair (BER). In this research,
Xu, Meng
core  

Ionisation potential and electron affinity of free 5′,8-cyclopurine-2′-deoxynucleosides. DFT study in gaseous and aqueous phase

, 2010
Oxidatively generated damage to DNA frequently appears in the human genome as an effect of aerobic metabolism or as the result of exposure to exogenous oxidizing agents.
B. Karwowski
semanticscholar   +1 more source

5-Carboxamido-5-formamido-2-iminohydantoin, in Addition to 8-oxo-7,8-Dihydroguanine, Is the Major Product of the Iron-Fenton or X-ray Radiation-Induced Oxidation of Guanine under Aerobic Reducing Conditions in Nucleoside and DNA Contexts

Journal of Organic Chemistry, 2015
Exogenously and endogenously produced reactive oxygen species attack the base and sugar moieties of DNA showing a preference for reaction at 2′-deoxyguanosine (dG) sites.
Omar R. Alshykhly, A. Fleming, C. Burrows   +2 more
semanticscholar   +1 more source

Exploration of Ataxia Telangiectasia and Rad3-Related’s (ATR’s) Role in Cell Death Regulation: Implications in Development, Cancer, and Stroke [PDF]

, 2019
From gametogenesis until death an organism’s genome is under constant bombardment from endogenous and exogenous sources of DNA damage. To maintain genomic integrity amid this damage, cells have evolved responses which allow them to either preserve ...
Cartwright, Brian
core   +1 more source

The difference in stability between 5′R and 5′S diastereomers of 5′,8-cyclopurine-2′-deoxynucleosides. DFT study in gaseous and aqueous phase

, 2010
Oxidatively generated damage to DNA frequently appears in the human genome as an effect of aerobic metabolism or as the result of exposure to exogenous oxidizing agents.
B. Karwowski
semanticscholar   +1 more source

A Quantitative Assay for Assessing the Effects of DNA Lesions on Transcription

Nature Chemical Biology, 2012
Most mammalian cells in nature are quiescent but actively transcribing mRNA for normal physiological processes; thus, it is important to investigate how endogenous and exogenous DNA damage compromises transcription in cells.
Changjun You, X. Dai, Bifeng Yuan, Jin Wang, Jianshuang Wang, P. J. Brooks, L. Niedernhofer, Yinsheng Wang   +7 more
semanticscholar   +1 more source

Editorial: Radiation-induced and oxidative DNA damages

Frontiers in Chemistry, 2015
The study of DNA lesions and changes, produced by interaction with UV or ionizing radiation and by the effects of oxidative stress, is a multidisciplinary research field in life sciences that has yelded exciting discoveries in the last few decades.
A. Monari, É. Dumont, C. Chatgilialoglu
semanticscholar   +1 more source

Chemistry and Biology of 8,5\u27-Cyclo-2\u27-deoxyguanosine and Other DNA Lesions

, 2013
8,5’-Cyclopurine deoxynucleosides are unique tandem lesions containing an additional covalent bond between the base and the sugar. These mutagenic and genotoxic lesions are repaired only by nucleotide excision repair (NER). It was shown that the R-cdA is
Das, Rajat S
core   +1 more source

Advances in Nucleic Acid Research: Exploring the Potential of Oligonucleotides for Therapeutic Applications and Biological Studies. [PDF]

Int J Mol Sci, 2023
Moccia M, Pascucci B, Saviano M, Cerasa MT, Terzidis MA, Chatgilialoglu C, Masi A.   +6 more
europepmc   +1 more source