Results 21 to 30 of about 14,629 (132)

Evaluation of the level of 5'-nucleotidase and some biochemical parameters in the sera of beta-thalassemia patients

Tikrit Journal of Pure Science, 2023
One of the hydrolytic enzymes that catalyzes the hydrolysis of 5' -nucleotides into ribonucleosides and phosphate is the 5'nucleotidase, which is found in several organs.
Sameer M. Al-Gorany, Mohammed Rajeh Altutnchi   +1 more
doaj   +1 more source

Effects of physical exercise on the functionality of human nucleotidases: A systematic review

Physiological Reports, 2022
Nucleotidases contribute to the regulation of inflammation, coagulation, and cardiovascular activity. Exercise promotes biological adaptations, but its effects on nucleotidase activities and expression are unclear.
Cesar Eduardo Jacintho Moritz, Alexandra Ferreira Vieira, Denise deMelo‐Marins, Fabrício Figueiró, Ana Maria Oliveira Battastini, Alvaro Reischak‐Oliveira   +5 more
doaj   +1 more source

Extracellular Vesicles from Bothrops jararaca Venom Are Diverse in Structure and Protein Composition and Interact with Mammalian Cells

Toxins, 2022
Snake venoms are complex cocktails of non-toxic and toxic molecules that work synergistically for the envenoming outcome. Alongside the immediate consequences, chronic manifestations and long-term sequelae can occur. Recently, extracellular vesicles (EVs)
Larissa Gonçalves-Machado, Brunno Renato Farias Verçoza, Fábio César Sousa Nogueira, Rafael Donadélli Melani, Gilberto Barbosa Domont, Silas Pessini Rodrigues, Juliany Cola Fernandes Rodrigues, Russolina Benedeta Zingali   +7 more
doaj   +1 more source

Estradiol regulation of nucleotidases in female reproductive tract epithelial cells and fibroblasts. [PDF]

PLoS ONE, 2013
The use of topical and oral adenosine derivatives in HIV prevention that need to be maintained in tissues and cells at effective levels to prevent transmission prompted us to ask whether estradiol could influence the regulation of catabolic nucleotidase ...
Zheng Shen, John V Fahey, Jack E Bodwell, Marta Rodriguez-Garcia, Richard M Rossoll, Sarah G Crist, Mickey V Patel, Charles R Wira   +7 more
doaj   +1 more source

5′-Nucleotidase and AMP-deaminase activities of liver postnuclear fraction and blood serum of rats with transplanted Guerin’s carcinoma

Біологічні студії, 2009
The dynamics of the levels of 5′-nucleotidase and AMP-deaminase activity in postnuclear fraction of rat liver and serum was studied during transplanted Guerin’s carcinoma growth in rats.
H. P. Kopylchuk, I. M. Buchkovska, O. M. Voloschuk   +2 more
doaj   +1 more source

Expression of major ectonucleotidases after cortical stab brain injury in rats: A real-time PCR study [PDF]

Archives of Biological Sciences, 2014
Ectonucleotidases are cell surface-located enzymes responsible for the extracellular degradation of nucleotides. They are comprised of several protein families: ectonucleoside triphosphate diphosphohydrolases (E-NTPDase), ectonucleotide ...
Parabucki Ana, Savić Danijela, Laketa Danijela, Peković Sanja, Stojiljković Mirjana, Nedeljković Nadežda, Bjelobaba Ivana   +6 more
doaj   +1 more source

ATP- and Adenosine-Mediated Signaling in the Central Nervous System: Adenosine Receptor Activation by ATP Through Rapid and Localized Generation of Adenosine by Ecto-nucleotidases

Journal of Pharmacological Sciences, 2004
Extracellular ATP is now recognized as a neurotransmitter or neuromodilator in the nervous system, producing diverse physiological effects by activating multiple P2 receptors.
Isao Matsuoka, Satoko Ohkubo
doaj   +1 more source

Pyrimidine 5’Nucleotidase I and II Activities in Acute Leukaemias

Acta Medica, 2004
Summary: Bacground and objective: Pyrimidine 5’nucleotidase I and II activities of peripheral mononuclear cells were studied to evaluate their role in diagnosis, assessment of therapy and follow up of remission in acute leukaemias.
Haci Kemal Erdemli, Bahattin Adam, Nüket Bavbek   +2 more
doaj   +1 more source

Additional file 2: of Ecto-5â ˛-nucleotidase (CD73) attenuates inflammation after spinal cord injury by promoting macrophages/microglia M2 polarization in mice

, 2018
CD73 deficiency increased marrow edema and enhancement. Representative micro-MRI images of spinal cord at 3 days post-injury. (PDF 459 kb)
Xu, Shun, Zhu, Wei, Shao, Minghao, Zhang, Fan, Guo, Ji, Xu, Haocheng, Jiang, Jianyuan, Ma, Xiaosheng, Xia, Xinlei, Zhi, Xiuling, Zhou, Ping, Lu, Feizhou   +11 more
openaire   +1 more source

Oleanolic acid blocks the purine salvage pathway for cancer therapy by inactivating SOD1 and stimulating lysosomal proteolysis

Molecular Therapy: Oncolytics, 2021
Metabolic reprogramming is a core hallmark of cancer and is key for tumorigenesis and tumor progression. Investigation of metabolic perturbation by anti-cancer compounds would allow a thorough understanding of the underlying mechanisms of these agents ...
Dan Liu, Xing Jin, Guanzhen Yu, Mingsong Wang, Lei Liu, Wenjuan Zhang, Jia Wu, Fengying Wang, Jing Yang, Qin Luo, Lili Cai, Xi Yang, Xisong Ke, Yi Qu, Zhenye Xu, Lijun Jia, Wen-Lian Chen   +16 more
doaj   +1 more source