Results 31 to 40 of about 12,326,283 (294)

Challenges and opportunities of bioprocessing 5-aminolevulinic acid using genetic and metabolic engineering: a critical review

Bioresources and Bioprocessing, 2021
5-Aminolevulinic acid (5-ALA), a non-proteinogenic five-carbon amino acid, has received intensive attentions in medicine due to its approval by the US Food and Drug Administration (FDA) for cancer diagnosis and treatment as photodynamic therapy.
Ying-Chen Yi, I-Tai Shih, Tzu-Hsuan Yu, Yen-Ju Lee, I-Son Ng   +4 more
doaj   +1 more source

5-Aminolevulinic acid hydrochloride enhances bupivacaine-induced hypotension in spontaneously hypertensive rats

Journal of Pharmacological Sciences, 2023
Purpose: Oral administration of 5-aminolevulinic acid hydrochloride (5-ALA-HCl) has been reported to enhance the hypotensive effects associated with anesthetics, especially in elderly hypertensive patients treated with antihypertensive agents.
Noboru Fukuda, Mayumi Katakawa, Hidenori Ito, Takeshi Hara, Noboru Otsuka, Masahiro Ishizuka, Masanori Abe   +6 more
doaj   +1 more source

Increasing the frost resistance of ‘Golden Delicious’, ‘Gala’ and ‘Šampion’ apple cultivars

Folia Horticulturae, 2016
The aim of this research was the evaluation of whether the application of 5-ALA, which has potential as a plant growth stimulating agent with indirect anti-stress activity, can limit the damage caused by low temperatures in winter.
Łysiak Grzegorz P., Kurlus Robert, Michalska Anna   +2 more
doaj   +1 more source

An in vitro study of the effect of 5-ALA-mediated photodynamic therapy on oral squamous cell carcinoma

BMC Oral Health, 2020
Background The primary aim of this study was to observe the effect of 5-ALA-mediated photodynamic therapy on oral squamous cell carcinoma in vitro. Methods SCC25 cells were divided into the observation group and the blank control group.
Ying Ma, Shujuan Qu, Liangpeng Xu, Hongbo Lu, Baoguo Li   +4 more
doaj   +1 more source

Unveiling the Effect of NCgl0580 Gene Deletion on 5-Aminolevulinic Acid Biosynthesis in Corynebacterium glutamicum

Fermentation, 2023
5-Aminolevulinic acid (5-ALA) has recently received much attention for its wide applications in medicine and agriculture. In this study, we investigated the effect of NCgl0580 in Corynebacterium glutamicum on 5-ALA biosynthesis as well as its possible ...
Jian Wu, Meiru Jiang, Shutian Kong, Kunqiang Hong, Juntao Zhao, Xi Sun, Zhenzhen Cui, Tao Chen, Zhiwen Wang   +8 more
doaj   +1 more source

Genetic factors affecting intraoperative 5-aminolevulinic acid-induced fluorescence of diffuse gliomas

Radiology and Oncology, 2017
In patients operated for malignant glioma, 5-aminolevulinic acid (5-ALA)-induced fluorescence guidance is useful. However, we occasionally experience instances of non-visible fluorescence despite a histopathological diagnosis of high-grade glioma.
Saito Kiyotaka, Hirai Toshinori, Takeshima Hideo, Kadota Yoshihito, Yamashita Shinji, Ivanova Asya, Yokogami Kiyotaka   +6 more
doaj   +1 more source

Photodynamic therapy of prostate cancer by means of 5-aminolevulinic acid-induced protoporphyrin IX - In vivo experiments on the dunning rat tumor model [PDF]

, 2004
Objective: In order to expand the use of photodynamic therapy (PDT) in the treatment of prostate carcinoma (PCA), the aim of this study was to evaluate PDT by means of 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX ( PPIX) in an in vivo tumor ...
Schneede, Peter, Lein, Michael, Bise, Karl, Zaak, Dirk, Baumgartner, Reinhold, Stocker, Susanne, Höppner, Michael, Kriegmair, Martin, Knüchel, Ruth, Hofstetter, Alfons, Frimberger, Dominic, Sroka, Ronald, Reich, Oliver   +12 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

5‐Aminolevulinic acid and sodium ferrous citrate ameliorate muscle aging and extend healthspan in Drosophila

FEBS Open Bio, 2022
Declines in mitochondrial functions are associated with aging. The combination of 5‐aminolevulinic acid (5‐ALA) and sodium ferrous citrate (SFC) improves mitochondrial functions in cultured cells.
Naoko Nozawa, Marie Noguchi, Kanako Shinno, Maki Tajima, Shingo Aizawa, Taro Saito, Akiko Asada, Takuya Ishii, Masahiro Ishizuka, Koichi M. Iijima, Kanae Ando   +10 more
doaj   +1 more source

Fluorophores Use in Pituitary Surgery: A Pharmacokinetics and Pharmacodynamics Appraisal

Brain Sciences, 2021
(1) Background: Despite many surgical and technological advances, pituitary adenoma surgery is still burdened by non-negligible rates of incomplete tumor resection, mainly due to difficulties in differentiating pathology from normal pituitary tissue ...
Daniele Bongetta, Fulvio Tartara, Fabio Pagella, Teresa Somma, Marilou Cavaliere, Giuseppe Di Perna, Francesco Zenga, Fabio Cofano, Diego Garbossa, Cesare Zoia   +9 more
doaj   +1 more source