Results 11 to 20 of about 12,326,283 (294)

Boosting 5-ALA-based photodynamic therapy by a liposomal nanomedicine through intracellular iron ion regulation

Acta Pharmaceutica Sinica B, 2021
5-Aminolevulinic acid (5-ALA) has been approved for clinical photodynamic therapy (PDT) due to its negligible photosensitive toxicity. However, the curative effect of 5-ALA is restricted by intracellular biotransformation inactivation of 5-ALA and ...
Airong Li, Chenglin Liang, Lihua Xu, Yiyang Wang, Wei Liu, Kaixiang Zhang, Junjie Liu, Jinjin Shi   +7 more
doaj   +1 more source

5‐ALA in the management of malignant glioma [PDF]

Lasers in Surgery and Medicine, 2018
BackgroundPatients suffering from malignant gliomas have a poor prognosis. For the surgical treatment of these tumors, 5‐aminolevulinic acid (5‐ALA) has become a new standard.AimsThis review intends to provide an overview over current status, significance, limitations, and future perspectives of 5‐ALA based fluorescence guided surgery and photodynamic ...
Herbert, Stepp, Walter, Stummer
openaire   +2 more sources

Effect of Silver Nanoparticles on Improving the Efficacy of 5-Aminolevulinic Acid-Induced Photodynamic Therapy [PDF]

Iranian Journal of Medical Physics, 2018
Introduction: The most important limitation of 5-aminolevulinic acid (5-ALA)-induced photodynamic therapy (PDT) is the efficacy of the cells in converting 5-ALA to protoporphyrin IX.
Samaneh Yazdi, Majid Darroudi, Armin Imanparast, Fatemeh Hataminia, Ameneh Sazgarnia   +4 more
doaj   +1 more source

5-ALA and FDA approval for glioma surgery [PDF]

Journal of Neuro-Oncology, 2019
The US Food and Drug Administration (FDA) approved 5-aminolevulinic acid (5-ALA; Gleolan®; photonamic GmbH and Co. KG) for use as an intraoperative optical imaging agent in patients with suspected high-grade gliomas (HGGs) in 2017. This was the first ever optical imaging agent approved as an adjunct for the visualization of malignant tissue during ...
Constantinos G. Hadjipanayis, Walter Stummer   +1 more
openaire   +2 more sources

Predictive biomarkers for 5‐ALA‐PDT can lead to personalized treatments and overcome tumor‐specific resistances

Cancer Reports, 2022
Background Photodynamic therapy (PDT) is a minimally invasive, clinically approved therapy with numerous advantages over other mainstream cancer therapies.
Maria Mastrangelopoulou, Mantas Grigalavicius, Tine H. Raabe, Ellen Skarpen, Petras Juzenas, Qian Peng, Kristian Berg, Theodossis A. Theodossiou   +7 more
doaj   +1 more source

Synthesis of [l-Ala-1]RA-VII, [d-Ala-2]RA-VII, and [d-Ala-4]RA-VII by Epimerization of RA-VII, an Antitumor Bicyclic Hexapeptide from Rubia Plants, through Oxazoles

, 2016
Three epimers of a natural cyclic hexapeptide RA-VII were prepared via formation of oxazoles from thioamides or thioimidates of RA-VII followed by hydrolysis. They are the epimers at l-Ala-1, d-Ala-2, and d-Ala-4, respectively.
Hideji Itokawa (2710573), Yuji Matsumoto (585815), Koichi Takeya (1941823), Yukio Hitotsuyanagi (1941826), Kentaro Yamaguchi (1415581), Shin-ichi Sasaki (1780183)   +5 more
core   +4 more sources

Kinetics of 5-aminolevulinic acid-induced fluorescence in organ cultures of bronchial epithelium and tumor [PDF]

, 2002
Background: 5-Aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PPIX) fluorescence improves the differentiation of tumor and normal tissue in the bladder, skin and brain. Objective: The kinetics of 5-ALA-induced protoporphyrin IX (PPIX) fluorescence
Bergner, Albrecht, Maier, Irmgard, Gamarra, Fernando, Al-Batran, Salah, Baumgartner, Reinhold, Wagner, Simon, Castro, Mirna, Hautmann, Hubert, Huber, Rudolf M.   +8 more
core   +1 more source

5-Aminolevulinic acid improves chicken sperm motility [PDF]

Animal Bioscience, 2021
Objective This study investigated the effects of 5-aminolevulinic acid (5-ALA) on the motility parameters, mitochondrial membrane depolarization, and ATP levels in chicken sperm. Methods The pooled semen from Barred Plymouth Rock males was used.
Shin Taniguchi, Zhendong Zhu, Mei Matsuzaki, Masaoki Tsudzuki, Teruo Maeda   +4 more
doaj   +1 more source

Dietary 5-aminolevulinic acid supplementation improves growth performance, nutrient utilisation, iron status and antioxidant capacity of broilers

Italian Journal of Animal Science, 2022
This study aimed to investigate the effects of dietary supplementation with 5-aminolevulinic acid (5-ALA) on growth performance, blood parameters, iron status, nutrient digestibility, and antioxidant capacity in broilers.
Jiang Chen, Zhimin Chen, Zedong Wang, Aijuan Zheng, Wenhuan Chang, Huiyi Cai, Guohua Liu   +6 more
doaj   +1 more source

Extending the Indications of 5-Aminolevulinic Acid for Fluorescence-Guided Surgery for Different Central Nervous System Tumors: A Series of 255 Cases in Latin America

Brazilian Neurosurgery, 2022
Introduction Fluorescence guidance with 5-aminolevulinic acid (5-ALA) is a safe and reliable tool in total gross resection of intracranial tumors, especially malignant gliomas and cases of metastasis.
Erasmo Barros da Silva Jr, Ricardo Ramina, Maurício Coelho Neto, Guilherme Augusto de Souza Machado, Marcella Santos Cavalcanti, Joseph Franklin Chenisz da Silva   +5 more
doaj   +1 more source