Results 1 to 10 of about 200,890 (163)
Comparative experimental study of 5-ALA and 5-ALA hexyl ester specific activity
Biomedical Photonics, 2018 A comparative experimental study of the specific activity of drugs based on 5-aminolevulinic acid (5-ALA) and its hexyl ester (5-ALA HE) was carried out. Their ability to induce the synthesis of photoactive protoporphyrin IX in the healthy tissues of the
R. I. Yakubovskaya +6 more
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5-ALA/Fe2+ attenuates testicular inflammatory injury and spermatogenic failure in non-obstructive azoospermia mice by suppressing the TP53-CASP3 apoptotic cascade [PDF]
Frontiers in Cell and Developmental BiologyBackgroundNon-obstructive azoospermia (NOA) remains a major challenge in the management of male infertility, with currently limited effective therapeutic options available.
Jiewen Zhu +12 more
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Pharmaceuticals, 2021 5-Aminolevulinic acid (5-ALA) is an amino acid derivative and a precursor of protoporphyrin IX (PpIX). The photophysical feature of PpIX is clinically used in photodynamic diagnosis (PDD) and photodynamic therapy (PDT).
Ryosuke Ando +2 more
exaly +3 more sources
Cancer stem cell populations are resistant to 5-aminolevulinic acid-photodynamic therapy (5-ALA-PDT) [PDF]
Scientific ReportsPhotodynamic therapy (PDT) is a minimally invasive treatment approved for many types of cancers. PDT involves the administration of photoactive substances called photosensitizers (PS) that selectively accumulate in cancer cells and are subsequently ...
Chantel P. J. Rice +3 more
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5-ALA fluorescence in indeterminate grade gliomas [PDF]
Neurosurgical Focus: Video, 2022 5-Aminolevulinic acid (5-ALA) is a useful and well-established adjunct for glioblastoma surgery. A growing body of evidence has revealed the potential utility of 5-ALA in grade II and grade III glioma patients as well. However, reliable means of identifying in whom fluorescence will occur have not been established.
Müther, Michael, Stummer, Walter
openaire +2 more sources
The Potential of 5-aminolevulinic Acid as a Contrast Agent in MR Imaging: Challenges and Opportunities [PDF]
Journal of Sciences, Islamic Republic of Iran, 2021 Nowadays, 5-aminolevulinic acid (5-ALA) plays an influential role in the detection of malignant tumors as a photodynamic diagnosis tool. Nevertheless, an outlook regarding 5-ALA applicability in magnetic resonance imaging (MRI) has recently emerged. Many
anita Ebrahimpour +2 more
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Frontiers in Oncology, 2023 IntroductionComplete macroscopic cytoreduction represents the most important prognostic parameter for overall survival in ovarian cancer. This dogma remains tenacious despite significant improvements in adjuvant systemic treatment. Hence, optimization of
Laura Tascón Padrón +7 more
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Brain Sciences, 2023 Background: Since its introduction in 2007 in Europe and in 2017 in the United States, 5-ALA has demonstrated an undisputed advantage in providing real-time tumor visualization.
Giuseppe Maria Della Pepa +2 more
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AN INTERDISCIPLINARY APPROACH FOR UNVEILING AND ENHANCING THE FIRST WORLD WAR HERITAGE IN THE LANDSCAPE [PDF]
ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2022 More than one hundred years ago, the European landscape was profoundly transformed by multiple factors related to the Great War, which altered its territorial and environmental ecosystems, giving the landscape the value of a cultural asset with a ...
J. Aldrighettoni, M. G. D’Urso
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Enhanced anti-tumor efficacy of 5-aminolevulinic acid-gold nanoparticles-mediated photodynamic therapy in cutaneous squamous cell carcinoma cells [PDF]
Brazilian Journal of Medical and Biological Research, 2020 The objective of this study was to investigate whether the conjugation of gold nanoparticles (GNPs) to 5-aminolevulinic acid (5-ALA) could enhance the anti-tumor efficiency of photodynamic therapy (PDT) in epidermoid carcinoma cells. The mRNA and protein
Yu-fei Chi +4 more
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