Results 81 to 90 of about 12,326,283 (294)

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source

ALA Headquarters Reporter, Vol. 5, No. 6

, 1967
Originally found in ALA Archives, RS 2/4 ...
ALA Staff Association
core  

Interleukin‐1α Mediates Pancreatic Fibroblast Activation, Regulates Immune Cell Recruitment and Fibrosis in Acute and Chronic Pancreatitis

Advanced Science, EarlyView.
During pancreatitis, IL‐1α is released from necrotic acinar cells. In response to IL‐1α, pancreatic fibroblasts release chemokines and cytokines that regulate the recruitment of immune cells to the damaged organ. Furthermore, IL‐1α primes fibroblasts, resulting in increased tissue fibrosis during chronic pancreatitis.
Hala Mazloum, Shenja Buchholz, Hanna Schifter, Sabine Ameling, Leif Steil, Ben Lewin Becker, Elke Hammer, Georg Homuth, Uwe Völker, Barbara M. Bröker, Lukas Zierke, Frank Ulrich Weiss, Juliane Glaubitz, Matthias Sendler   +13 more
wiley   +1 more source

INTRAOPERATIVE FLUORESCENCE-GUIDED RESECTION OF HIGH-GRADE GLYOBLASTOMA USING 5-AMINOLEVULINIC ACID: A META-ANALYSIS

Сибирский онкологический журнал, 2017
Background. Glioblastoma (GBM) is a high-grade primary brain tumor characterized by resistance to modern treatment modalities. Intraoperative fluorescence-guided resection using 5-aminolevulinic acid (5-ALA) is one of the most innovative techniques to ...
V. A. Byvaltsev, I. A. Stepanov
doaj   +1 more source

ALA Headquarters Reporter, Vol. 5, No. 4

, 1967
Originally found in ALA Archives, RS 2/4 ...
ALA Staff Association
core  

Ab Initio Thermoelectric Transport Calculations of Alloyed Half‐Heuslers

Advanced Science, EarlyView.
The effect of alloying on the electronic transport of half‐Heusler thermoelectric materials is explored using a fully ab initio approach. A novel method is developed that combines calculations of alloyed supercells with Boltzmann transport, considering the full energy and momentum dependent scattering processes from first principles extracted ...
Ankit Kumar, Bhawna Sahni, Neophytos Neophytou   +2 more
wiley   +1 more source

ALA Headquarters Reporter, Vol. 5, No. 7

, 1967
Originally found in ALA Archives, RS 2/4 ...
ALA Staff Association
core  

Lactylation‐Driven PROS1‐TYRO3‐CARF Signaling Promotes Therapy‐Induced Senescence Escape and Radioresistance in Meningioma

Advanced Science, EarlyView.
A glycolysis‐driven epigenetic switch promotes therapy resistance in meningioma. Increased lactate production enhances histone H3K27 lactylation, which activates PROS1 secretion. Secreted PROS1 engages TYRO3 signaling to degrade the senescence regulator CARF, allowing cancer cells to escape growth arrest.
Zhuohang Wang, Qixiang Zhang, Keman Liao, Xiaoyu Liu, Hongchi Zhang, Yunsheng Chen, Yuxiao Ma, Yikui Liu, Aoqian Xu, Yuhao Sun, Jiayi Chen, Liuguan Bian, Baofeng Wang   +12 more
wiley   +1 more source

Ferroptosis promotes 5-aminolevulinate acid-based photodynamic therapy in cervical cancer

Photodiagnosis and Photodynamic Therapy
Background: Cervical cancer has the highest incidence rate among all gynecologic malignancies. Photodynamic therapy (PDT) is a minimal invasive treatment widely used in various tumors.
Qiyu Liu, Qin Han, Jiaxin Shi, Zhangxin Wu, Lingyu Ma, Yuan Li, Haojie He, Hongyan Guo   +7 more
doaj   +1 more source

ALA Headquarters Reporter, Vol. 5, No. 3

, 1967
Originally found in ALA Archives, RS 2/4 ...
ALA Staff Association
core