Results 201 to 210 of about 42,924 (245)
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Pharmacotherapy of benign prostatic hyperplasia: Inhibitor of 5 alpha-reductase
International Urology and Nephrology, 1997We studied the effects of 5 alpha-reductase inhibitor (finasteride) in the treatment of benign prostatic hyperplasia (BPH). This study is a randomized controlled trial. Sixty-two patients were treated with 5 alpha-reductase (finasteride 5 mg/day) and 61 patients (control group) with placebo for one year.
BAYRAKTAR, YILMAZ +4 more
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Prostate cancer prevention with 5-alpha reductase inhibitors
Current Opinion in Urology, 2018We review the concepts surrounding prostate cancer prevention strategies with 5-alpha reductase inhibitors (5-ARIs) and the controversies associated with their use.Updated data have shown no increased risk of death from the diagnosis of higher risk cancer; however, 5-ARIs remain controversial and not approved for prostate cancer prevention.The main ...
Michael A, Liss, Ian M, Thompson
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Novel aromatase and 5α-reductase inhibitors
The Journal of Steroid Biochemistry and Molecular Biology, 1994Inhibitors of aromatase and 5 alpha-reductase may be of use for the therapy of postmenopausal breast cancer and benign prostatic hyperplasia, respectively. FCE 27993 is a novel steroidal irreversible aromatase inhibitor structurally related to exemestane (FCE 24304).
E, Di Salle +7 more
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5-alpha-reductase inhibitors for prostate cancer prevention
Cochrane Database of Systematic Reviews, 2008Background Five-alpha-reductase inhibitors (5ARI) are frequently used to treat bothersome lower urinary tract symptoms associated with benign prostatic hyperplasia and male androgenic alopecia. They have potential as chemopreventive agents. Objectives We sought to estimate the effectiveness and harms of 5ARI in preventing prostate cancer ...
Timothy J Wilt +4 more
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Prostate Cancer Prevention with 5 Alpha-Reductase Inhibitors
2010Testosterone gets converted into the more potent 5-[alpha]-dihydrotestosterone by 5-[alpha]- reductase. dihydrotestosterone (DHT) controls prostate mitotic activity and potentially prostate carcinogenesis. Interventions that inhibit 5-[alpha]-reductase have potential as preventive agents for prostate cancer.
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Side Effects of 5‐Alpha Reductase Inhibitors: A Comprehensive Review
Sexual Medicine Reviews, 20135α-reductase inhibitors (5ARI) include finasteride and dutasteride, and are commonly prescribed in the treatment of benign prostatic hyperplasia and androgenic alopecia. 5ARIs are associated with several known adverse effects (AEs), with varying reported prevalence rates.The aim was to review and summarize findings from published literature detailing ...
Landon, Trost +2 more
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The role of 5-alpha-reductase inhibitors in active surveillance
Current Opinion in Urology, 2012Active surveillance is now considered one of the preferred treatments for men with favorable risk prostate cancer (PCa). Unfortunately, 30-50% of men choosing active surveillance will progress and require therapy. In this context, we will present recent data on the efficacy of 5-alpha-reductase inhibitors (5-ARIs) in secondary prevention among men with
David, Margel, Neil, Fleshner
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5-Alpha Reductase Inhibitors in Prostate Cancer
2010Androgenic effects in prostate cancer cells depend on the synthesis and metabolism of hormones and the presence of androgen receptor. 5-alpha reductase isoenzymes I and II differ in chromosomal localization, pH optimum, enzyme kinetics, and expression in benign and malignant prostate tissue.
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Finasteride: a 5 alpha-reductase inhibitor.
Clinical pharmacy, 1993The pharmacology and pharmacokinetics of finasteride are reviewed, and finasteride's clinical efficacy, adverse effects, and dosage in patients with benign prostatic hyperplasia (BPH) are described. Finasteride is a member of a new class of medications, the azasteroids, that have antiandrogenic activity limited to certain tissues, including the ...
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Long-Term Experience with 5-alpha-Reductase Inhibitors.
Reviews in urology, 2011Finasteride, a 5-alpha-reductase inhibitor, dramatically suppresses the production of dihydrotestosterone in men; thus, attention has turned to this agent for the treatment of benign prostatic hyperplasia (BPH). A number of randomized clinical trials have studied finasteride's effects on prostate size, BPH symptoms, flow rate, and prostate-specific ...
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