Results 201 to 210 of about 46,559 (243)
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5-Alpha-Reductase Inhibitors and Combination Therapy
Urologic Clinics of North America, 2016By inhibiting the conversion from testosterone to dihydrotestosterone 5-Alpha reductase inhibitors (5ARIs) are able to hinder prostatic growth, shrink prostate volumes, and improve BPH-related LUTS. 5ARIs are particularly beneficial for patients with larger prostates (>30-40ml).
Claudius Füllhase, Marc P Schneider
exaly +5 more sources
The risk of dementia with the use of 5 alpha reductase inhibitors
Journal of the Neurological Sciences, 2017There has been considerable interest in the interplay between testosterone and cognition. Dihydrotestosterone (DHT), which has been correlated with cognitive function, is significantly reduced with the use of 5 alpha reductase inhibitors (5ARI) for prostatic enlargement.
Blayne Welk +2 more
exaly +3 more sources
Discovery of Natural Steroid 5 Alpha-Reductase Inhibitors
Assay and Drug Development Technologies, 2019Human steroid 5 alpha-reductases (S5αRs) and NADPH irreversibly reduce testosterone to the more potent dihydrotestosterone (DHT). S5αR inhibitors are useful treatments for DHT-dependent diseases, including benign prostatic hyperplasia, androgenic alopecia and hair growth, and acne.
Jukkarin Srivilai +2 more
exaly +3 more sources
5-Alpha reductase inhibitors in active surveillance
Current Opinion in Urology, 2014Active surveillance is now one of the recommended treatment options for low-risk prostate cancer (PCa). However, about 10-30% of men on active surveillance will progress and require definitive therapy. In this review, we examine the role of 5-alpha reductase inhibitors (5-ARIs) in secondary prevention among men with low-risk PCa who opted to be managed
Patrick O, Richard, Antonio, Finelli
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5 Alpha-reductase inhibitors: whatʼs new?
Current Opinion in Urology, 2003Medical therapy is now the first-line treatment for most men with symptomatic benign prostatic hyperplasia. This review aims to highlight the recent contributions to our understanding of 5 alpha-reductase inhibitor usage.For the last decade, finasteride has been the only available 5 alpha-reductase inhibitor, acting upon the type 2 isoenzyme of 5-alpha
Charlotte L, Foley, Roger S, Kirby
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5-Alpha-reductase inhibitors in diseases of the prostate
Current Opinion in Endocrinology, Diabetes & Obesity, 2014To summarize the history of the use of 5-alpha-reductase inhibitors in the treatment of urologic diseases and discuss the current practices and indications for therapy.5-Alpha-reductase inhibitors (5-ARIs) are indicated in the treatment of benign prostatic hyperplasia (BPH) with obstructive urinary symptoms to reduce symptoms, reduce the risk of acute ...
Robert J, Carrasquillo +2 more
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Finasteride: A slow-binding 5.alpha.-reductase inhibitor
Biochemistry, 1993A microsomal preparation of human prostatic tissue was used to study the kinetics of interaction of steroid 5 alpha-reductase with finasteride, a known 5 alpha-reductase inhibitor. This molecule has been reported to reversibly bind 5 alpha-reductase in a competitive manner to testosterone with a Ki value in the 10 nM range.
B, Faller, D, Farley, H, Nick
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The role of 5-alpha-reductase inhibitors in active surveillance
Current Opinion in Urology, 2012Active surveillance is now considered one of the preferred treatments for men with favorable risk prostate cancer (PCa). Unfortunately, 30-50% of men choosing active surveillance will progress and require therapy. In this context, we will present recent data on the efficacy of 5-alpha-reductase inhibitors (5-ARIs) in secondary prevention among men with
David, Margel, Neil, Fleshner
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Azasteroids as inhibitors of rat prostatic 5.alpha.-reductase
Journal of Medicinal Chemistry, 1984A series of A-ring heterocyclic steroids has been prepared and tested for inhibition of rat prostatic steroid 5 alpha-reductase in vitro. Strikingly high inhibitory activity was found with a group of 17 beta-substituted 4-methyl-4-aza-5 alpha-androstan-3-ones. These compounds were prepared from 3-keto-delta 4-precursors by oxidative (O3 or NaIO4-KMnO4)
G H, Rasmusson +6 more
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