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5-Alpha Reductase Inhibitors in Prostate Cancer
2010Androgenic effects in prostate cancer cells depend on the synthesis and metabolism of hormones and the presence of androgen receptor. 5-alpha reductase isoenzymes I and II differ in chromosomal localization, pH optimum, enzyme kinetics, and expression in benign and malignant prostate tissue.
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Long-Term Experience with 5-alpha-Reductase Inhibitors.
Reviews in urology, 2011Finasteride, a 5-alpha-reductase inhibitor, dramatically suppresses the production of dihydrotestosterone in men; thus, attention has turned to this agent for the treatment of benign prostatic hyperplasia (BPH). A number of randomized clinical trials have studied finasteride's effects on prostate size, BPH symptoms, flow rate, and prostate-specific ...
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5 alpha-reductase inhibitors and prostatic disease.
Clinical endocrinology, 19945 alpha-Reductase inhibitors are a new class of substances with very specific effects on type I and type II 5 alpha R which may be of use in the treatment of skin disease, such as male pattern baldness, male acne and hirsutism, as well as prostatic hyperplasia and prostate cancer.
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Treatment of hirsutism with 5 alpha-reductase inhibitors.
Clinics in endocrinology and metabolism, 1986Much os the evidence gathered from studies of 5 alpha-reductase activity levels and androgen metabolism in the skin of hirsute women and the excretion of androgen metabolites by hirsute women indicates that 5 alpha-reduced androgens are probably of primary importance in hirsutism.
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