Results 41 to 50 of about 14,205,288 (205)

Integrated Purification Process for 5-Aminolevulinic Acid Phosphate Produced via Biological Fermentation

Separations
5-aminolevulinic acid (5-ALA) affords various positive health effects, including benefits for conditions such as diabetes. Biological fermentation holds potential for efficiently mass-producing biomolecules, including 5-ALA, yet it generally results in a
Naoyuki Iwata, Kazunari Fukumoto, Mitsuharu Uchino   +2 more
doaj   +1 more source

5-Aminolevulinic acid fluorescence guided resection of malignant glioma: Hong Kong experience

Asian Journal of Surgery, 2018
Summary: Background: 5-Aminolevulinic Acid (5-ALA) induced fluorescence is useful in guiding glioma resection. The extent of 5-ALA accumulation is beyond gadolinium contrast enhancement.1,2 Supratotal resection may be achieved, potentially granting ...
Danny Tat Ming Chan, Hsieh Yi-Pin Sonia, Wai Sang Poon   +2 more
doaj   +1 more source

Biological function of 5-aminolevulinic acid （5-ALA） and its application in animals production

Siliao yanjiu, 2023
5-ALA is a precursor substance of tetrapyrrole biomolecule synthase, which is involved in the synthesis of porphyrins and is closely related to the synthesis of heme and the absorption and utilization of iron in animals, and has the effect of improving ...
AN Yu-han, MA Yi-dan, YANG Jia, XING Xiao-kun, JI Peng, AN Qing-cong   +5 more
doaj  

Fluorescence Diagnosis of Metastatic Lymph Nodes Using 5-Aminolevulinic Acid (5-ALA) in a Mouse Model of Colon Cancer [PDF]

Journal of Surgical Research, 2012
Lymph node metastasis is one of the most critical prognostic factors in patients with colorectal cancer. Although regional lymph nodes should be surgically resected and pathologically examined, techniques for the intraoperative diagnosis of lymph node metastasis remain to be well established.
Kato, Shigeru, Kawamura, Junichiro, Kawada, Kenji, Hasegawa, Suguru, Sakai, Yoshiharu   +4 more
openaire   +3 more sources

5-Aminolevulinic acid synthase: mechanism, mutations and medicine

, 2003
5-Aminolevulinic acid synthase (ALAS), the first enzyme of the heme biosynthesis pathway, catalyses the pyridoxal 5'-phosphate-dependent condensation between glycine and succinyl-CoA to yield 5-aminolevulinic acid (5-amino-4-oxopentanoate).
Bottomley, S.S., Roy, I., Sarwar, M., Sawyer, L., Baxter, R.L., Shoolingin-Jordan, P., Kahari, D., Shoolingin-Jordan, P.M., Alexeev, D., Al-Daihan, S., Kahari, I.D., Wang, S.F.   +11 more
core   +1 more source

Characteristics of Fluorescent Intraoperative Dyes Helpful in Gross Total Resection of High-Grade Gliomas—A Systematic Review

Diagnostics, 2020
Background: A very important aspect in the treatment of high-grade glioma is gross total resection to reduce the risk of tumor recurrence. One of the methods to facilitate this task is intraoperative fluorescence navigation.
Marek Mazurek, Bartłomiej Kulesza, Filip Stoma, Jacek Osuchowski, Sławomir Mańdziuk, Radosław Rola   +5 more
doaj   +1 more source

Sequential Design of Activatable Photosensitizers for Ablation of Glioma Cells in Brain Cancer Tissues

Angewandte Chemie International Edition, EarlyView.
Gal‐SeNBD‐oleamide is an activatable photosensitizer (PS) with efficient uptake and selective, β‐galactosidase‐triggered activation in cancer cells, enabling efficient photodynamic ablation of glioma cells directly in brain tissue slices from mouse preclinical models and human glioblastoma patients.
Utsa Karmakar, Zhiming Cheng, Andrew D. M. Green, Sam Benson, Eleni Nestoros, Clarissa Lim, Justyna Cholewa‐Waclaw, Fabio de Moliner, Paula Lusarreta, Deborah Seah, Alsadeg Bilal, Neza Alfazema, Thibaud Aymoz‐Bressot, Gillian Morrison, Sonja Vermeren, Steven M. Pollard, Paul M. Brennan, Michael G. Tanner, Marc Vendrell   +18 more
wiley   +1 more source

Assessment of the efficacy and safety of auricular keloids excision followed by 5-aminolevulinic acid photodynamic therapy

Photodiagnosis and Photodynamic Therapy
Background: Auricular keloids are a significant clinical challenge, which adversely affect the life of the patient at the level of aesthetic and psychological well-being. Despite various treatment modalities, a universally effective therapy has yet to be
Ziyue Lu, Ding Zhu, Yunchuan Yang, Huiling Kou, Xinying Li, Junbo Zhang   +5 more
doaj   +1 more source

Click Bioconjugation of Aza‐BODIPY Fluorophores to LfcinB Peptides for Improved Biocompatibility

European Journal of Organic Chemistry, EarlyView.
Click bioconjugation attaches NIR aza‐BODIPY fluorophores to LfcinB‐derived anticancer peptides via CuAAC and thiol‐maleimide chemistry. Conjugates exhibit improved predicted solubility while retaining strong NIR absorption (703–730 nm). Peptide‐aza‐BODIPY conjugates induce apoptotic morphology in HeLa cancer cells.
A. Verónica Rodríguez‐Mayor, Maricela Morales, Héctor Manuel Pineda‐Castañeda, Zuly Jenny Rivera‐Monroy, Javier Eduardo García‐Castañeda, Norberto Farfán, Rosa Santillan   +6 more
wiley   +1 more source

Photodynamic Vvisualisation of Paratyroid Glands – Results of Clinical use Eng

Клиническая и экспериментальная тиреоидология, 2009
The purpose: an approbation of intraoperative photodynamic identification of healthy and adenomatous parathyroid glands using 5-aminolevulinic acid (5-ALA) at thyroid and parathyroid operations.Materials and methods: intraoperative photodynamic ...

doaj   +1 more source