Results 41 to 50 of about 18,317 (178)

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source

Dermoscopy and methyl aminolevulinate: A study for detection and evaluation of field cancerization [PDF]

, 2016
Actinic keratosis (AK) is a keratinocyte intraepidermal neoplasia UV light – induced that frequently appears in sun-exposed areas of the skin. Although historically AK was de fi ned as “ precancerous ” , actually it is considered as the ...
Anzalone, Alessia, Cardone, Michele, Carlesimo, Marta, De Vita, G., Di Nunno, D., Fortuna, MARIA CATERINA, Garelli, Valentina, Mari, Elena, Pranteda, Giulia, Rossi, Alfredo   +9 more
core   +1 more source

Design Strategies for Novel Lipid Nanoparticle for mRNA Vaccine and Therapeutics: Current Understandings and Future Perspectives

MedComm, Volume 6, Issue 10, October 2025.
This review summarizes strategies to optimize lipid nanoparticles (LNPs) for improved targeting, endosomal escape, and safety. It highlights mRNA design, alternative delivery systems, and recent therapeutic advances across infectious diseases, cancer, and drug applications.
Xiaochi Li, Junli Li, Jiazheng Wei, Weixin Du, Cheng Su, Xiaobin Shen, Aihua Zhao, Miao Xu   +7 more
wiley   +1 more source

Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B12) [PDF]

, 2013
It has been known for the past 20 years that two pathways exist in nature for the de novo biosynthesis of the coenzyme form of vitamin B12, adenosylcobalamin, representing aerobic and anaerobic routes.
Biedendieck, Rebekka, Deery, Evelyne, Frank, Stefanie, Howard, Mark J., Lawrence, Andrew D., Moore, Simon J., Rigby, Stephen E. J., Warren, Martin J.   +7 more
core   +1 more source

Microwave‐Assisted One‐Pot Synthesis of Alkyl Levulinates From Post‐Harvest Vegetable Waste

Advanced Sustainable Systems, Volume 9, Issue 9, September 2025.
Vegetable waste is valorized through Soxhlet extraction using H₂O₂ and heteropolyacid (HPA), followed by material characterization (XRD, FTIR, TGA, DSC). A microwave‐assisted reaction at 170 °C for 30 min with HPA and alcohol yields bio‐based esters.
Ángel G. Sathicq, Luis A. Gallego‐Villada, Edwin Alarcón, Andrés Felipe Monroy, José J. Martínez, Gustavo P. Romanelli   +5 more
wiley   +1 more source

British Association of Dermatologists and British Photodermatology Group guidelines for topical photodynamic therapy 2018 [PDF]

, 2019
The overall objective of the guideline is to provide up-to-date, evidence-based recommendations for the use of topical photodynamic therapy (PDT). The document aims to: • offer an appraisal of all relevant literature up to April 2018, focusing on any key
Collier, Nick, Exton, Luke S., Haylett, Ann K., Ibbotson, Sally, Mallipeddi, Rajeev, McKenna, K. E., Mohd Mustapa, M. Firouz, Morton, C. A., Moseley, Harry, Rhodes, Lesley E., Seukeran, Daron C., Ward, K. A., Wong, Terence   +12 more
core   +2 more sources

Oil components modulate the skin delivery of 5-aminolevulinic acid and its ester prodrug from oil-in-water and water-in-oil nanoemulsions

International Journal of Nanomedicine, 2011
The study evaluated the potential of nanoemulsions for the topical delivery of 5-aminolevulinic acid (ALA) and methyl ALA (mALA). The drugs were incorporated in oil-in-water (O/W) and water-in-oil (W/O) formulations obtained by using soybean oil or ...
Li-wen Zhang, S. Al-suwayeh, C. Hung, Chih-Chieh Chen, Jia-You Fang   +4 more
semanticscholar   +1 more source

Highly Targeted Metabolomics Coupled With Gene Expression Analysis by RT–qPCR Improves Beef Separation Based on Grass, Grain, or Grape Supplemented Diet

Food Frontiers, Volume 6, Issue 3, Page 1483-1497, May 2025.
ABSTRACT The objective of this study was to use a multi‐omics (i.e., gene expression quantification, metabolomics, and fatty acid [FA] profiling) approach to separate and authenticate beef from three different dietary groups. In this 2‐year study, Red Angus steers (n = 54) were randomly allocated to one of three treatments: (1) complex biodiverse ...
Lucas Krusinski, Chloe Castanon, Rosalee S. Hellberg, Isabella C. F. Maciel, Muhammad Ahsin, Stephan van Vliet, Jason E. Rowntree, Jenifer I. Fenton   +7 more
wiley   +1 more source

Photoactivable oxobenzopyranoxazole esters of 5-aminolevulinic acid [PDF]

, 2016
Comunicação em painel P51 no 1st European Young Chemists Meeting/ 5th Portuguese Young Chemists Meeting, Guimarães, Portugal, 26-29 Abril 2016.In this communication we report the synthesis of new oxobenzopyranoxazoles 1a,b as photolabile protecting ...
Costa, Susana P. G., Gonçalves, M. Sameiro T., Soares, Ana Maria Silva   +2 more
core  

Regulatory and retrograde signaling networks in the chlorophyll biosynthetic pathway

Journal of Integrative Plant Biology, Volume 67, Issue 4, Page 887-911, April 2025.
This review summarizes the regulatory mechanisms that underlie chlorophyll synthesis, including (1) factors that control the activity and stability of tetrapyrrole biosynthesis enzymes, (2) transcriptional and post‐translational regulation of the tetrapyrrole biosynthesis pathway, and (3) the complex roles of tetrapyrrole‐mediated retrograde signaling ...
Yuhong Li, Tianjun Cao, Yunling Guo, Bernhard Grimm, Xiaobo Li, Deqiang Duanmu, Rongcheng Lin   +6 more
wiley   +1 more source