Results 51 to 60 of about 344,744 (207)

Toxicity of Gold Nanoparticles in Mice due to Nanoparticle/Drug Interaction Induces Acute Kidney Damage

Nanoscale Research Letters, 2020
Nanomaterials are innovative materials with many useful properties, but there is concern regarding their many unknown effects on living organisms. Gold nanoparticles are widely used as industrial materials because of their excellent properties.
Katsuhiro Isoda, Anju Tanaka, Chisaki Fuzimori, Miyuki Echigoya, Yuichiro Taira, Ikuko Taira, Yoshimi Shimizu, Yoshihiro Akimoto, Hayato Kawakami, Isao Ishida   +9 more
doaj   +1 more source

Designing of pH-Sensitive Hydrogels for Colon Targeted Drug Delivery; Characterization and In Vitro Evaluation

Gels, 2022
In the current research work, pH-sensitive hydrogels were prepared via a free radical polymerization technique for the targeted delivery of 5-aminosalicylic acid to the colon.
Muhammad Suhail, Yu-Fang Shao, Quoc Lam Vu, Pao-Chu Wu   +3 more
doaj   +1 more source

Impact of 5‐ASA discontinuation in children with ulcerative colitis on biologic therapy: A propensity score‐matched study

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives 5‐Aminosalicylic acid (5‐ASA) is recommended as a first‐line medication in mild to moderate ulcerative colitis (UC), but indications regarding its use in children with moderate to severe disease treated with biologics are lacking.
Giulia D'Arcangelo, Luca Scarallo, Giulia Mancuso, Mara Corpino, Claudio Romano, Lorenzo Norsa, Serena Arrigo, Matteo Bramuzzo, Maria Teresa Fioretti, Giovanna Zuin, Maria Teresa Illiceto, Paolo Lionetti, Marina Aloi   +12 more
wiley   +1 more source

5‐Aminosalicylic Acid in the Treatment of Inflammatory Bowel Disease [PDF]

Acta Medica Scandinavica, 1984
STIG BONDESEN, STEN N0RBY RASMUSSEN, JQRGEN RASK-MADSEN, OLE HAAGEN NIELSEN, KARSTEN LAURITSEN, VIBEKE BINDER, STEEN HONORB HANSEN and EIGILL E HVIDBERG From the Department of Medicine 6 Glostrup Hospital, Glostrup, the Department of Medicine I , Aalborg Hospital North, Aalborg, the Department of Medicine B, Bispebjerg Hospital, Copenhagen, the ...
S, Bondesen, S N, Rasmussen, J, Rask-Madsen, O H, Nielsen, K, Lauritsen, V, Binder, S H, Hansen, E F, Hvidberg   +7 more
openaire   +2 more sources

The Mycobacterium tuberculosis Rv0132c Gene Product Mtb‐FGD2 Can Act as an F420‐Dependent Glucose Dehydrogenase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The role of the cell envelope‐associated Rv0132c/FGD2 from Mycobacterium tuberculosis has long been a subject of debate. Importantly, FGD2 is found only in pathogenic mycobacteria, making it a potential drug target. While some suggest it functions as a glucose‐6‐phosphate dehydrogenase, others propose it acts instead as an F420‐dependent ...
Adewale V. Aderemi, Matthew Snee, Richard B. Tunnicliffe, Linus O. Johanissen, Matthew J. Cliff, Colin W. Levy, Derren J. Heyes, Marina Golovanova, Thomas A. Jowitt, Sam Hay, Andrew W. Munro, Jonathan P. Waltho, David Leys   +12 more
wiley   +1 more source

2-Hydroxy-5-{[(E)-4-methoxybenzylidene]azaniumyl}benzoate

Acta Crystallographica Section E, 2010
In the title zwitterion, C15H13NO4, obtained from the condensation of 5-aminosalicylic acid and 4-methoxybenzaldehyde, the 4-hydoxyanilinic group of the 5-aminosalicylic acid moiety and the 4-methoxybenzaldehyde moiety are twisted with respect to one ...
Shahbaz Ahmad, Muhammad Ilyas Tariq, M. Nawaz Tahir, Muhammad Sarfraz   +3 more
doaj   +1 more source

Betulinic Acid Enema Alleviates Colitis by Targeting Vitamin D Receptor to Protect the Intestinal Mucosal Barrier and Modulate Mucosa‐Associated Microbiota

Phytotherapy Research, EarlyView.
ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with limited effectiveness and safety of current drug therapies. Betulinic acid (BA) is a naturally occurring pentacyclic triterpenoid present in traditional Chinese medicines used clinically as retention enemas for UC, but its direct effects and mechanisms remain unclear ...
Lina Dong, Yuanxia Gao, Qian Li, Guangxin Chen, Dong Yang, Liping Zhao, Xiaojing Liu, Shumei Lin   +7 more
wiley   +1 more source

Asian Pacific Association of Gastroenterology (APAGE) Clinical Practice Guidelines on the Use of Small Molecules and IL‐23 p19 Inhibitors in Ulcerative Colitis and Crohn's Disease

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Ulcerative colitis (UC) and Crohn's disease (CD) are increasingly prevalent in the Asia Pacific region, necessitating updated, region‐specific guidance on advanced therapies. Targeted small molecule agents, such as filgotinib, tofacitinib, upadacitinib, etrasimod, and ozanimod; and the IL‐23 p19 inhibitors (guselkumab, mirikizumab ...
Choon Jin Ooi, Khoon Lin Ling, Julajak Limsrivilai, Shu‐Chen Wei, Joyce Wing Yan Mak, Taku Kobayashi, Luan Minh Dang, Rupert W. Leong, Huiyu Lin, Meng‐Tzu Weng, Wan Chee Ong, Vineet Ahuja, Satimai Aniwan, Ryota Hokari, Wei Jie Jonathan Lee, Alex Hwong‐Ruey Leow, Wai‐Keung Leung, Wee‐Chian Lim, Govind Makharia, Katsuyoshi Matsuoka, Nazri Mustaffa, Siew‐Chien Ng, Mathew Philip, Pises Pisespongsa, Raja Affendi Raja Ali, Zhi Hua Ran, Marcellus Simadibrata, Jose Sollano, Malcolm Tan, Hang Dao Viet, Nik Razima Wan Ibrahim, Kai Chun Wu, Byong Duk Ye, Ida Hilmi, Asian Pacific Association of Gastroenterology (APAGE) Inflammatory Bowel Disease Committee and Asian Education Network in IBD (AEN‐IBD)   +34 more
wiley   +1 more source

Antioxidant effect of 5-amino salicylic acid on copper-mediated LDL oxidation

Biological Research, 2007
The antioxidant effect of 5-Aminosalicylic acid (5-ASA) on copper-mediated LDL oxidation was followed either by the emitted chemiluminiscence (CL) or by UV-vis spectroscopy. 5-ASA addition extends the lag phase in a concentration-dependent manner without
CAMILO LÓPEZ-ALARCÓN, HERNÁN SPEISKY, EDUARDO LISSI   +2 more
doaj  

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source