Results 51 to 60 of about 21,523 (223)

Oral beclometasone dipropionate in the treatment of extensive and left-sided active ulcerative colitis: a multicentre randomised study. [PDF]

, 2003
AIM: To explore the efficacy and safety of the topically acting steroid beclometasone dipropionate (BDP) in an oral controlled release formulation in the treatment of extensive or left-sided ulcerative colitis.
Adamo S, Campieri M, Casetti T, Castiglione GN, Cesari P, D'Albasio G, D'ARIENZO, AGESILAO, Gionchetti P., Manguso F, Pitzalis M, Rizzello F, Valpiani D, Varoli G   +12 more
core   +1 more source

Multimodal MRI and multiomics reveal high‐risk neurophenotype in brain‐gut circuits as therapeutic target for Crohn's disease

Interdisciplinary Medicine, EarlyView.
Through a translational framework combining prospective dual‐center clinical cohorts with dextran sulfate sodium‐induced colitis models, this work integrated advanced neuroimaging, multi‐omics and neuromodulation interventions to redefine the high‐risk neurophenotype as a sustained pathogenic driver rather than a mere phenomenon, proposing brain‐gut ...
Xuehua Li, Ruonan Zhang, Xiaodi Shen, Shaochun Lin, Chuhuai Wang, Weikai Zheng, Weimiao Kong, Zihao Lin, Rongchang Li, Caiguang Liu, Xin Cao, Li Huang, Weitao He, Jinjiang Lin, Haijie Wang, Zhoulei Li, Marietta Iacucci, Subrata Ghosh, Zhenpeng Peng, Canhui Sun, Minhu Chen, Guang Yang, Yejun Wang, Ren Mao, Shi‐Ting Feng   +24 more
wiley   +1 more source

Reduced Plasma Levels of sCD14 and I-FABP in HIV-infected Patients with Mesalazine-treated Ulcerative Colitis [PDF]

, 2016
BACKGROUND: Microbial translocation (MT) is a shared feature of HIV infection and inflammatory bowel disease (IBD). AIMS: This study was conducted to assess the impact of IBD (and particularly ulcerative colitis, UC) on plasma markers of MT ...
Alessandra Fantauzzi, Caterina Fimiani, Chiara Pasquale, Clementina Maria Galluzzo, Gabriella d’Ettorre, Ivano Mezzaroma, Lucia Palmisano, Manuela Gatto, Manuela Merli, Marina Franco, Massimo Sanchez, Roberta Amici, Silvia Baroncelli, Vincenzo Vullo, Zuleika Michelini   +14 more
core   +1 more source

Impact of 5‐ASA discontinuation in children with ulcerative colitis on biologic therapy: A propensity score‐matched study

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives 5‐Aminosalicylic acid (5‐ASA) is recommended as a first‐line medication in mild to moderate ulcerative colitis (UC), but indications regarding its use in children with moderate to severe disease treated with biologics are lacking.
Giulia D'Arcangelo, Luca Scarallo, Giulia Mancuso, Mara Corpino, Claudio Romano, Lorenzo Norsa, Serena Arrigo, Matteo Bramuzzo, Maria Teresa Fioretti, Giovanna Zuin, Maria Teresa Illiceto, Paolo Lionetti, Marina Aloi   +12 more
wiley   +1 more source

Outcomes, infectiousness, and transmission dynamics of patients with extensively drug-resistant tuberculosis and home-discharged patients with programmatically incurable tuberculosis: a prospective cohort study. [PDF]

, 2017
BACKGROUND: The emergence of programmatically incurable tuberculosis threatens to destabilise control efforts. The aim of this study was to collect prospective patient-level data to inform treatment and containment strategies.
Abdallah, Abdallah M, Ben-Rached, Fathia, Clark, Taane G, Dheda, Keertan, Dolby, Tania, Esmail, Aliasgar, Fennelly, Kevin P, Gumbo, Tawanda, Lesosky, Maia, Limberis, Jason D, Mastrapa, Barbara, McNerney, Ruth, Pain, Arnab, Phelan, Jody, Pietersen, Elize, Simpson, John, Sirgel, Frederick A, Smith, Liezel, Streicher, Elizabeth M, Te Riele, Julian, Theron, Grant, van Helden, Paul, Warren, Robin M   +22 more
core   +1 more source

Toxicity of Gold Nanoparticles in Mice due to Nanoparticle/Drug Interaction Induces Acute Kidney Damage

Nanoscale Research Letters, 2020
Nanomaterials are innovative materials with many useful properties, but there is concern regarding their many unknown effects on living organisms. Gold nanoparticles are widely used as industrial materials because of their excellent properties.
Katsuhiro Isoda, Anju Tanaka, Chisaki Fuzimori, Miyuki Echigoya, Yuichiro Taira, Ikuko Taira, Yoshimi Shimizu, Yoshihiro Akimoto, Hayato Kawakami, Isao Ishida   +9 more
doaj   +1 more source

Designing of pH-Sensitive Hydrogels for Colon Targeted Drug Delivery; Characterization and In Vitro Evaluation

Gels, 2022
In the current research work, pH-sensitive hydrogels were prepared via a free radical polymerization technique for the targeted delivery of 5-aminosalicylic acid to the colon.
Muhammad Suhail, Yu-Fang Shao, Quoc Lam Vu, Pao-Chu Wu   +3 more
doaj   +1 more source

Sonoelectrochemically enhanced determination of 5-aminosalicylic acid

Talanta, 2001
The electrochemical detection of the anti-inflammatory drug 5-aminosalicylic acid (5-ASA) has been evaluated through the application of linear sweep, square wave and sonolinear sweep voltammetry. The introduction of ultrasound is shown to significantly enhance the oxidation signal intensity thereby enabling the detection of low concentrations with the ...
Beckett, E, Lawrence, N, Evans, R, Davis, J, Compton, R   +4 more
openaire   +3 more sources

"In vitro" activities of antimycobacterial agents against Mycobacterium avium subsp. paratuberculosis linked to Crohn's disease and paratuberculosis [PDF]

, 2006
Crohn's disease, a human disease similar to paratuberculosis in animals is the most painful and devastating disease that may involve infection with M. avium subsp.
Ahmed, Niyaz, Cannas, Sara, Molicotti, Paola, Ortu, Silvia, Sechi, Leonardo Antonio, Zanetti, Stefania Anna Lucia   +5 more
core  

The Mycobacterium tuberculosis Rv0132c Gene Product Mtb‐FGD2 Can Act as an F420‐Dependent Glucose Dehydrogenase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The role of the cell envelope‐associated Rv0132c/FGD2 from Mycobacterium tuberculosis has long been a subject of debate. Importantly, FGD2 is found only in pathogenic mycobacteria, making it a potential drug target. While some suggest it functions as a glucose‐6‐phosphate dehydrogenase, others propose it acts instead as an F420‐dependent ...
Adewale V. Aderemi, Matthew Snee, Richard B. Tunnicliffe, Linus O. Johanissen, Matthew J. Cliff, Colin W. Levy, Derren J. Heyes, Marina Golovanova, Thomas A. Jowitt, Sam Hay, Andrew W. Munro, Jonathan P. Waltho, David Leys   +12 more
wiley   +1 more source