Results 31 to 40 of about 13,247 (180)

A novel dual-prodrug carried by cyclodextrin inclusion complex for the targeting treatment of colon cancer

Journal of Nanobiotechnology, 2021
Background There is an obvious correlation between ulcerative colitis and colorectal cancer, and the risk of colorectal cancer in patients with ulcerative colitis is increasing. Therefore, the combination therapy of anti-inflammatory and anti-tumor drugs
Lin Chen, Yan Lin, Zijun Zhang, Ruisheng Yang, Xiaosheng Bai, Zhongbing Liu, Zhongling Luo, Meiling Zhou, Zhirong Zhong   +8 more
doaj   +1 more source

Long‐Term Outcomes After Stoma Creation in Crohn's Disease: A Retrospective Cohort Study of 422 Patients

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim Stoma creation is often required in Crohn's disease (CD), most commonly because of progressive anorectal disease. As stoma closure strongly influences long‐term quality of life and surgical decision‐making, this study evaluated the indications and long‐term outcomes of stoma creation in patients with CD.
Kentaro Nagano, Ryuichi Kuwahara, Yusuke Tomoo, Kurando Kusunoki, Yuki Horio, Kei Kimura, Kozo Kataoka, Masataka Ikeda, Motoi Uchino, Hiroki Ikeuchi   +9 more
wiley   +1 more source

What is the optimal timing to assess the effect of 5-ASA in patients with mild-to-moderate ulcerative colitis? A single-center prospective observational study

European Journal of Medical Research
Background First-line therapy for mild-to-moderate ulcerative colitis is 5-aminosalicylic acid. Optimal timing for the first evaluation after initiation remains unclear.
Yu Da, Fang Wang, Jiaqi Zhang, Tiantian Zhang, Xiaoning Liu, Jindan He, Yanting Shi, Tong Wu, Jie Liang   +8 more
doaj   +1 more source

Inflammatory Indexes for Assessing the Severity and Disease Progression of Ulcerative Colitis: A Single-Center Retrospective Study

Frontiers in Public Health, 2022
BackgroundActive and severe ulcerative colitis (UC) and non-response to 5-aminosalicylic acid (5-ASA) are related to poor outcomes and should be accurately identified.
Hanyang Lin, Hanyang Lin, Zhaohui Bai, Zhaohui Bai, Qiong Wu, Guiyang Chu, Yongguo Zhang, Xiaozhong Guo, Xingshun Qi, Xingshun Qi, Xingshun Qi   +10 more
doaj   +1 more source

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source

Renal Effects of Long-Term Treatment with 5-Aminosalicylic Acid

Canadian Journal of Gastroenterology, 2009
BACKGROUND: A number of case reports link the use of 5-aminosalicylic acid (5-ASA) to interstitial nephritis in patients with inflammatory bowel disease (IBD).
Harshna Patel, Aiala Barr, Khursheed N Jeejeebhoy   +2 more
doaj   +1 more source

Preparation and in-vitro characterization of 5-aminosalicylic acid loaded hydrogels for colon specific delivery

Journal of Materials Research and Technology, 2022
The aim of the current investigation was to prepare and characterize the novel pH-sensitive hydrogels of pluronic F127 and sodium polystyrene sulfonate for the controlled delivery of 5-aminosalicylic acid to colon.
Muhammad Suhail, Ming-Chia Hung, I-Hui Chiu, Quoc Lam Vu, Pao-Chu Wu   +4 more
doaj   +1 more source

Exclusive enteral nutrition containing transforming growth factor‐β improves intestinal barrier function in a colitis mouse model

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Exclusive enteral nutrition (EEN) is the first‐line treatment for pediatric Crohn's disease, but its mechanisms of action remain poorly understood. Our aim was to identify the mechanisms that could explain the anti‐inflammatory effects of EEN, studying the nutritional composition and transforming growth factor‐β (TGF‐β) effects, in ...
Kawthar Boumessid, Vickie Lacroix, Ekaterina Ovtchinnikova, Sophie Thenet, Marie Carriere, Frédérick Barreau, Emmanuel Mas   +6 more
wiley   +1 more source

Betulinic Acid Enema Alleviates Colitis by Targeting Vitamin D Receptor to Protect the Intestinal Mucosal Barrier and Modulate Mucosa‐Associated Microbiota

Phytotherapy Research, EarlyView.
ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with limited effectiveness and safety of current drug therapies. Betulinic acid (BA) is a naturally occurring pentacyclic triterpenoid present in traditional Chinese medicines used clinically as retention enemas for UC, but its direct effects and mechanisms remain unclear ...
Lina Dong, Yuanxia Gao, Qian Li, Guangxin Chen, Dong Yang, Liping Zhao, Xiaojing Liu, Shumei Lin   +7 more
wiley   +1 more source

Synthesis, crystal structure and Hirshfeld surface analysis of a 1:1 salt of sparfloxacin and 4-aminosalicylic acid

Acta Crystallographica Section E: Crystallographic Communications
The anhydrous salt of sparfloxacin [5-amino-1-cyclopropyl-7-(3,5-dimethylpiperazin-1-yl)-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid] with 4-aminosalicylic acid, C22H22F2N4O3+·C7H6NO3−, features both intermolecular (N—H...O) and ...
Bhumi C. Patel, Krunal M. Modi, J. Prakasha Reddy   +2 more
doaj   +1 more source