Results 41 to 50 of about 13,247 (180)

Sulfasalazine Enhances Copper Toxicity in Danio rerio Larvae: Divergent Protective Roles of Deferoxamine and Ferrostatin‐1

Environmental Toxicology, EarlyView.
ABSTRACT Copper is an environmental contaminant capable of disrupting redox homeostasis and impairing antioxidant defenses in aquatic organisms, thereby increasing susceptibility to oxidative stress. The cystine/glutamate antiporter (system xc−) plays a central role in maintaining intracellular glutathione (GSH) levels, a major antioxidant defense ...
Maria Vitória Takemura Mariano, Pedro Henrique Vicenzi, Vitor Oliveira de Rosso, Mauro Eugênio Medina Nunes, Layla da Silva Braga, Analía Del Valle Garnero, Ricardo José Gunski, Marcelo Farina, Thaís Posser, Jeferson Luis Franco   +9 more
wiley   +1 more source

5‐Aminosalicylic Acid in the Treatment of Inflammatory Bowel Disease [PDF]

Acta Medica Scandinavica, 1984
STIG BONDESEN, STEN N0RBY RASMUSSEN, JQRGEN RASK-MADSEN, OLE HAAGEN NIELSEN, KARSTEN LAURITSEN, VIBEKE BINDER, STEEN HONORB HANSEN and EIGILL E HVIDBERG From the Department of Medicine 6 Glostrup Hospital, Glostrup, the Department of Medicine I , Aalborg Hospital North, Aalborg, the Department of Medicine B, Bispebjerg Hospital, Copenhagen, the ...
S, Bondesen, S N, Rasmussen, J, Rask-Madsen, O H, Nielsen, K, Lauritsen, V, Binder, S H, Hansen, E F, Hvidberg   +7 more
openaire   +2 more sources

Review Article: The Impact of the Gut Microbiome on Ulcerative Colitis Pharmacotherapy

Alimentary Pharmacology &Therapeutics, EarlyView.
The gut microbiome modulates ulcerative colitis pharmacotherapy through microbial drug metabolism, immune regulation and altered drug bioavailability. Microbial composition influences response to aminosalicylates, corticosteroids, immunomodulators, biologics and small molecules, while microbiome‐targeted therapies show emerging promise.
Kate Collins, Srinivas Kamath, Rachel H. Davis, Samuel P. Costello, Robert V. Bryant, Alice S. Day, Paul Joyce   +6 more
wiley   +1 more source

Toxicity of Gold Nanoparticles in Mice due to Nanoparticle/Drug Interaction Induces Acute Kidney Damage

Nanoscale Research Letters, 2020
Nanomaterials are innovative materials with many useful properties, but there is concern regarding their many unknown effects on living organisms. Gold nanoparticles are widely used as industrial materials because of their excellent properties.
Katsuhiro Isoda, Anju Tanaka, Chisaki Fuzimori, Miyuki Echigoya, Yuichiro Taira, Ikuko Taira, Yoshimi Shimizu, Yoshihiro Akimoto, Hayato Kawakami, Isao Ishida   +9 more
doaj   +1 more source

Inflammatory Bowel Disease Is Associated With an Increased Risk of End‐Stage Renal Disease: A Population‐Based Cohort Study

Alimentary Pharmacology &Therapeutics, EarlyView.
In a retrospective population‐based cohort study using the University of Manitoba IBD Epidemiology Database, persons with IBD have an increased risk of ESRD by nearly 50%, with CD showing greater risk than UC. Bowel surgery, allopurinol use and oral steroid therapy are important predictors, emphasising the necessity of careful renal monitoring in IBD ...
Onuma Sattayalertyanyong, Zoann Nugent, Bryce Barr, Keevin N. Bernstein, Charles N. Bernstein   +4 more
wiley   +1 more source

Impact of Zinc‐Dependent Enzymes on Zinc Deficiency and Inflammatory Response in Ulcerative Colitis

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background and Aim Zinc (Zn) deficiency occurs in 40% of patients with ulcerative colitis (UC). Although Zn‐dependent enzymes are involved in intestinal immune regulation, their relationships with Zn deficiency and mucosal inflammation remain unclear.
Yuki Murakami, Taiho Kambe, Yu Kobayashi, Aki Sakatani, Katsuyoshi Ando, Nobuhiro Ueno, Kentaro Moriichi, Mikihiro Fujiya   +7 more
wiley   +1 more source

Antioxidant effect of 5-amino salicylic acid on copper-mediated LDL oxidation

Biological Research, 2007
The antioxidant effect of 5-Aminosalicylic acid (5-ASA) on copper-mediated LDL oxidation was followed either by the emitted chemiluminiscence (CL) or by UV-vis spectroscopy. 5-ASA addition extends the lag phase in a concentration-dependent manner without
CAMILO LÓPEZ-ALARCÓN, HERNÁN SPEISKY, EDUARDO LISSI   +2 more
doaj  

Determination of 5-aminosalicylic acid in pharmaceutical formulations by square wave voltammetry at pencil graphite electrodes

Química Nova, 2010
An analytical method for the determination of the anti-inflammatory drug 5-aminosalicylic acid (5-ASA) in pharmaceutical formulations using square wave voltammetry at pencil graphite electrodes was developed.
Carolina V. Uliana, Hideko Yamanaka, Gustavo S. Garbellini, Giancarlo R. Salazar-Banda   +3 more
doaj   +1 more source

Sonoelectrochemically enhanced determination of 5-aminosalicylic acid

Talanta, 2001
The electrochemical detection of the anti-inflammatory drug 5-aminosalicylic acid (5-ASA) has been evaluated through the application of linear sweep, square wave and sonolinear sweep voltammetry. The introduction of ultrasound is shown to significantly enhance the oxidation signal intensity thereby enabling the detection of low concentrations with the ...
Beckett, E, Lawrence, N, Evans, R, Davis, J, Compton, R   +4 more
openaire   +3 more sources

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source