Results 171 to 180 of about 11,853,684 (309)

Sensing‐Integrated Patient‐Derived Tumorspheres Predict Chemotherapeutic Efficacy via Local Extracellular pH Dynamics

Small, EarlyView.
The study introduces a 3D sensing‐integrated platform enabling real‐time, non‐invasive monitoring of pH dynamics in patient‐derived PDAC tumorspheres. It revealed distinct extracellular acidification patterns under FOLFIRINOX, gemcitabine, and paclitaxel, correlating with therapeutic efficacy.
Stefania Forciniti, Valentina Onesto, Anna Chiara Siciliano, Helena Iuele, Stefano D'Ugo, Norma Depalma, Cinzia Fasano, Alessandro D'Amuri, Giuseppe Gigli, Marcello G. Spampinato, Loretta L. del Mercato   +10 more
wiley   +1 more source

4% 5-Fluorouracil Cream for Actinic Keratoses: First Report of Efficacy and Tolerability in a Person Living With Human Immunodeficiency Virus Infection. [PDF]

Clin Case Rep
Hoxhallari G, Portincasa A, Fini N, Verdura V, Cecchino LR, Lembo F, Caputo SL, Bonamonte D, Foti C, Drago F, Ciccarese G.   +10 more
europepmc   +1 more source

Rare Cutaneous Metastasis From Esophageal Squamous Cell Carcinoma

The Kaohsiung Journal of Medical Sciences, EarlyView.
Sarah Hsin Cheng, Yen‐Shuo Huang, Chi‐En Hsiao, Hui‐Hua Hsiao   +3 more
wiley   +1 more source

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source

Hyperammonemic encephalopathy after 5-fluorouracil chemotherapy. [PDF]

CMAJ
Salimi P, Soriano A, Crocker E, Goldenberg B.   +3 more
europepmc   +1 more source

Advances in research on layered double hydroxides for biomedical applications

Smart Molecules, EarlyView.
Layered double hydroxides (LDHs) are pH‐responsive nanomaterials with broad biomedical applications. This review summarizes LDH synthesis methods and compares their advantages. It highlights LDHs' progress in cancer therapy, including chemo‐photothermal, chemo‐immunotherapy, and photodynamic‐immunotherapy combinations and their potential in bone repair.
Xinhui Yang, Zhiping Zhang, Zhao Wang, Hao Zhang, Yen Leng Pak, Yingying Jing, Yurong Guo, Fang Li, Xiao Wang, Quanxiang Han, Lei Yu, Xuejiao Li, Xing Gao, Jibin Song   +13 more
wiley   +1 more source

Beware the Ides of Chemotherapy: A Report on Hyperammonemic Encephalopathy Induced by FOLFOX-6 (5-Fluorouracil, Leucovorin, and Oxaliplatin). [PDF]

Cureus
Ts S, Balaji S, K D, S K, Ts K, Subramanian Y, Paul AJ, Adalarasan S, N J, C H.   +9 more
europepmc   +1 more source

Recent Advances in Oriented Hydrogels: From Fundamental Mechanisms to Future Challenges

SusMat, EarlyView.
Traditional hydrogels suffer from weak mechanical properties and limited functionality due to their random polymer networks. This review comprehensively summarizes the reinforcement mechanisms of oriented structure for hydrogels, the design/fabrication strategies, and the latest application progress of high‐strength oriented hydrogels.
Chang Xu, Xijing Zhuang
wiley   +1 more source

Uridine Triacetate for Severe Fluoropyrimidine Cardiotoxicity in a Patient With Thymidylate Synthase Gene Variants

JACC. CardioOncology, 2020
Inbar Raber, MD, Morgan B. Frazer, PharmD, BCOP, Jessica A. Zerillo, MD, MPH, Aarti Asnani, MD   +3 more
doaj   +1 more source

Silicone elastomer films loaded with 5-fluorouracil for time-dependent drug release. [PDF]

Sci Rep
Atabekyan M, Farmazyan Z, Avagyan N, Topuzyan V, Babayan N, Harutyunyan K, Sarkisyan N, Grigoryan R, Grigoryan S.   +8 more
europepmc   +1 more source