Results 171 to 180 of about 9,064,090 (287)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Correction: Nobiletin reduces 5-FU-induced lung injury with antioxidative, anti-inflammatory and anti-apoptotic activities. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Atila Uslu G, Uslu H, Çoban TA, Özkaraca M, Mendil AS, Aygörmez S.   +5 more
europepmc   +1 more source

5-FU-induced Acute Leukoencephalopathy

Internal Medicine, 2004
ISHIBASHI, Satoru, NISHIMURA, Hisatsugu, MIZUSAWA, Hidehiro   +2 more
openaire   +3 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Glutathione metabolism-associated resistance to cisplatin and 5-FU in esophageal cancer: a paired transcriptomic study. [PDF]

BMC Gastroenterol
Hirasaki M, Miyawaki Y, Kamakura Y, Kawasaki T, Yamasaki S, Fukushima H, Makino Y, Sato H, Hamaguchi T.   +8 more
europepmc   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

New regimen of conbination therapy with CDDP and 5-FU. Preceding induction with 5-FU.

Japanese jornal of Head and Neck Cancer, 1994
Masamitsu NAGAHARA, Takashi OKUMURA, Kenji HATTOLI, Takeshi KUBO, Akio SIGYOU, Motoko KOUNO, Hironobu ARITA, Hideharu ARUGA   +7 more
openaire   +3 more sources

Subcellular Redistribution of Endomembrane GPR15 Promotes NAD+-Mediated Metabolic Reprogramming and Boosts 5-FU Chemosensitivity in Colorectal Cancer. [PDF]

Cancer Res
Yue Z, Dai W, Cao Z, Hu B, Wang Z, Ma X, Qin D, Zhang T, Sang Q, Mei J, Yu T, Zhou Y, Luo Z, Xu J, Yuan Z, Li YY, Zhang J, Huang C, Yang Z.   +18 more
europepmc   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Comparative preventive effects of probiotic and postbiotic preparations of <i>Lacticaseibacillus rhamnosus</i> L156.4 and GG in a 5-FU-induced mucositis model. [PDF]

Gut Microbes Rep
Munis Campos G, Viegas Santos RC, Silva Quaresma L, Ferrary Américo M, Guimarães Sousa E, Gomes GC, Freitas ADS, Lima Barroso FA, Elias Moreira Júnior R, Brunialti Godard AL, de Souza RP, Ferreira E, Pires LO, Antunes Fernandes SO, Cardoso VN, Canário Viana MV, Figueiredo Siqueira MDS, Carvalho RDO, Lima de Jesus LC, Santos TM, Le Loir Y, Guédon E, Azevedo V.   +22 more
europepmc   +1 more source