Results 171 to 180 of about 12,458,805 (285)

Molecular mechanisms of 5-FU resistance in colorectal cancer: the regulatory role of lncRNAs. [PDF]

J Cancer Res Clin Oncol
Bai B, Guo Y, Xie X, Wang C.
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Synthesis of liver-targeting dual-ligand modified GCGA/5-FU nanoparticles and their characteristics in vitro and in vivo

, 2013
Mingrong Cheng,1,2,* Xiaoyan Gao,3,* Yong Wang,4,* Houxiang Chen,5 Bing He,6 Yingchun Li,2 Jiang Han,1 Zhiping Zhang11Department of General Surgery, Pudong New Area District Zhoupu Hospital, Shanghai, People’s Republic of China; 2Department of ...
Li Y, Zhang Z, Chen M, Gao X, Chen H, Han J, Wang Y, He B   +7 more
core  

Early kinetics of CA19-9 and CEA after 5-FU-based chemotherapy for gastrointestinal cancers. [PDF]

Discov Oncol
Lange S, Wenzel P, Winter C, Ruland J, Schmid RM, Algül H, Quante M, Friedrich M.   +7 more
europepmc   +1 more source

5-FU-induced Acute Leukoencephalopathy

Internal Medicine, 2004
ISHIBASHI, Satoru, NISHIMURA, Hisatsugu, MIZUSAWA, Hidehiro   +2 more
openaire   +3 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

NKD1 promotes the progression and 5-FU resistance of colorectal cancer via the Wnt/β-catenin signaling. [PDF]

Cell Death Dis
Dong L, Yang Z, Xu Z, Huang G, Yang X, Lv Y, Huang K, Liu Z, Zhang F, Jiang K, Yu Z.   +10 more
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Comparison of 24 Versus 46-Hour 5-FU Infusion Durations in the Perioperative FLOT Therapy for Gastric Cancer. [PDF]

Medicina (Kaunas)
Gokcek S, Can Sancı P, Karakayalı A, Eniseler EB, Kılınc M, Yetginoglu O, Kalem A, Koseoglu C, Ekinci F, Uzun M, Semiz HS, Unek IT.   +11 more
europepmc   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source