Results 51 to 60 of about 7,934 (184)

Aetiopathogenesis of infantile epileptic spasms syndrome and mechanisms of action of adrenocorticotrophin hormone/corticosteroids in children: A scoping review

Developmental Medicine &Child Neurology, EarlyView.
Why does infantile epileptic spasms syndrome (IESS) occur with a variety of underlying conditions and why does it respond to adrenocorticotrophin hormone (ACTH)/corticosteroids? Our scoping review summarizes five hypotheses from the literature: gene/epigenetic regulation, stress/HPA axis activation, neuroinflammation/immune function, altered neuronal ...
Emily A. Innes, Velda X. Han, Shrujna Patel, Michelle A. Farrar, Deepak Gill, Shekeeb S. Mohammad, Russell C. Dale   +6 more
wiley   +1 more source

The impact of re‐characterizing metastatic pancreatic neuroendocrine tumors: A prospective study

Journal of Neuroendocrinology, EarlyView.
Abstract The biology of metastatic pancreatic neuroendocrine tumors (panNET) may alter over time. It remains to be defined if, how, and when this patient group should be recommended to re‐evaluate the characteristics of their disease. This prospective single‐center, longitudinal cohort study at Uppsala University Hospital, Sweden (NCT03130205 ...
Kazhan Mollazadegan, Johan Botling, Britt Skogseid, Barbro Eriksson, Lovisa Falkman, Liang Zhang, Ieva Lase, Staffan Welin, Anders Sundin, Joakim Crona   +9 more
wiley   +1 more source

The diagnostic utility of urinary 5-HIAA and leucine-rich alpha-2 glycoprotein in acute appendicitis: a narrative review

Frontiers in Medicine
BackgroundAcute appendicitis (AA) remains diagnostically challenging despite its global prevalence. Current methods rely on clinical scoring systems (e.g., Alvarado score) and imaging (US, CT, and MRI). Urinary biomarkers like 5-hydroxyindoleacetic acid (
Yahiya Baig, Aamer Mohammed, Alexandra E. Butler   +2 more
doaj   +1 more source

MRI‐based surrogates of brain clearance in narcolepsy type 1

Journal of Sleep Research, EarlyView.
Summary Brain clearance involves the drainage of waste molecules from the brain, a process that is suggested to be amplified during sleep. Recently proposed MRI‐based methods attempt to approximate human brain clearance with surrogate measures. The current study aimed to explore whether two brain clearance surrogates are altered in narcolepsy.
Eva M. van Heese, Jari K. Gool, Gert Jan Lammers, Ysbrand D. van der Werf, Matthias J. P. van Osch, Rolf Fronczek, Lydiane Hirschler   +6 more
wiley   +1 more source

Identifying Key Biomarkers in Pediatric Pulmonary Hypertension: An Investigative Approach

Children
This study assesses the utility of early biomarkers—5-hydroxyindoleacetic acid (5-HIAA) and insulin-like growth factor 1 (IGF-1)—for diagnosing and monitoring pulmonary hypertension (PH) in children with congenital heart defects (CHD).
Farida Mindubayeva, Lyudmila Akhmaltdinova, Mariya Ospanova, Bibigul Tukbekova, Zhanat Bolatbekuly, Yuliya Niyazova, Yelena Salikhova, Olga Avdienko, Meruert Akhmetova   +8 more
doaj   +1 more source

Biological and Mechanical Limitations for Chronic Fast‐Scan Cyclic Voltammetry Sensor Design

Advanced Materials Technologies, Volume 10, Issue 11, June 5, 2025.
Real‐time detection of neurochemicals has demonstrated value in the field of neuroscience. However, current methods have limitations for use in the chronic setting, which is often the ideal environment for research. This article discusses these limitations, as well as technologies that have been developed to overcome them, and provides recommendations ...
Mason L. Perillo, Bhavna Gupta, Akash Saxena, Alexandra P. Veltri, Wen Li, James R. Siegenthaler, Erin K. Purcell   +6 more
wiley   +1 more source

Excretion of Urinary 5-HIAA in Dog Pellagra.

Experimental Biology and Medicine, 1962
SummaryDogs kept on a diet deficient in tryptophan and nicotinic acid, developed typical pellagra, but their 5-HIAA urinary excretion did not differ from that of control dogs. The reasons for this discrepancy lie mainly i the typical course of canine pellagra which invariably results in early death due to intestinal or buccal infection (black tongue ...
E. L. Edelstein, J. E. Steiner, Felix Sulman, Y. Pfeifer   +3 more
openaire   +2 more sources

Docosahexaenoic Acid and Nervonic Acid Synergically Enhance Cognitive Memory in Normal Mice via Brain Fatty Acids Remodeling

eFood, Volume 6, Issue 3, June 2025.
1. DHA and NA can enhance memory by increasing their levels in gray and white matter. 2. DHA and NA can enhance memory by increasing their levels in gray and white matter. 3. DHA and NA combination regulate spatial memory in a dose‐specific manner. ABSTRACT Docosahexaenoic acid (DHA) and nervonic acid (NA) are the main components of brain gray and ...
Hai‐Yan Ou, Lei Feng, Rui‐Ye Chen, Hui‐Yun Lu, Shuang Cai, Zhi‐You Yang   +5 more
wiley   +1 more source

Butyrate alleviates food allergy by improving intestinal barrier integrity through suppressing oxidative stress‐mediated Notch signaling

iMeta, Volume 4, Issue 3, June 2025.
Compared to healthy controls, children with food‐sensitized tolerance and food allergy showed reduced fecal short‐chain fatty acids (SCFAs), particularly butyrate. In an ovalbumin‐sensitized mouse model, butyrate outperformed other SCFAs in alleviating allergic responses.
Jialu Shi, Wenjun Mao, Yuqing Song, Yuxin Wang, Lili Zhang, Yan Xu, Huiwen Gu, Siyu Yao, Yuanhang Yao, Zhifeng Liu, Vijaya Raghavan, Jin Wang   +11 more
wiley   +1 more source

Monoamine oxidase A activity in fibroblasts as a functional confirmation of MAOA variants

JIMD Reports, 2021
Monoamine oxidase A (MAO‐A) deficiency is a rare inborn error of metabolism with impaired degradation of biogenic amines including 5‐hydroxytryptamine (5‐HT), resulting in borderline intellectual disability and behavioral abnormalities.
Tessa M. A. Peters, Irma Lammerts van Bueren, Ben P.B.H. Geurtz, Karlien L. M. Coene, Nicole deLeeuw, Han G. Brunner, Jón J. Jónsson, Michèl A. A. P. Willemsen, Ron A. Wevers, Marcel M. Verbeek   +9 more
doaj   +1 more source