Results 61 to 70 of about 7,934 (184)

Vitamin C Transport Deficiency Alters Striatal Dopamine Gene Expression and Metabolism in YAC128 Huntington Disease Mice

Genes, Brain and Behavior, Volume 24, Issue 3, June 2025.
ABSTRACT Neurodegeneration in Huntington disease (HD) contributes to dopaminergic system dysfunction via the loss of striatal medium spiny neurons expressing dopamine receptors. Given the key role for ascorbic acid (vitamin C) in dopamine synthesis and neurotransmission, we investigated whether mild cellular ascorbate deficiency accelerates ...
Adriana A. Tienda, Fiona E. Harrison, Jordyn M. Wilcox   +2 more
wiley   +1 more source

Pharmacokinetic analysis on compatibility of Atractylodes macrocephala and Paeoniae radix herb pair ameliorates functional constipation model rats using microdialysis with ultra‐performance liquid chromatography

Animal Models and Experimental Medicine, Volume 8, Issue 5, Page 874-885, May 2025.
The active ingredient of the drug determines the effect of the drug, and the compatibility affects the content of the active ingredient of the drug, which in turn affects the exertion of the efficacy. This study partly clarifies the rationality and compatibility of AM‐PR in the treatment of FC.
Xiaoting Wang, Xiaojun Li, Rui Zhang, Yin Hong, Jiaqi Guan   +4 more
wiley   +1 more source

Neutrophils in Tissue Injury and Repair: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 6, Issue 5, May 2025.
Tissue repair is a highly intricate and ordered dynamic process that heavily relies on the orchestration of immune cells. In addition to their well‐established antimicrobial functions in innate immunity, neutrophils also play an indispensable role in tissue repair.
Luying Yang, Fan Shi, Feng Cao, Le Wang, Jianzhen She, Boling He, Xiaoying Xu, Liang Kong, Bolei Cai   +8 more
wiley   +1 more source

Patients with Allan‐Herndon‐Dudley Syndrome (MCT8 Deficiency) Display Symptoms of Parkinsonism in Childhood and Respond to Levodopa/Carbidopa Treatment

Movement Disorders, Volume 40, Issue 5, Page 938-949, May 2025.
Abstract Background Patients with mutations in the monocarboxylate transporter 8 (MCT8, SLC16A2) suffer from X‐linked recessive Allan‐Herndon‐Dudley syndrome (AHDS), which is characterized by developmental delay and a severe movement disorder. Current trials using thyroid hormone derivatives to overcome the transporter defect have failed to achieve ...
Nina‐Maria Wilpert, Angela L. Hewitt, Roser Pons, Marie‐Thérèse Henke, Andrea Dell'Orco, Martin Bauer, Christiane Grolik, Stephan Menz, Monika Wahle, Annika Zink, Alessandro Prigione, Christina Reinauer, Catharina Lange, Christian Furth, Knut Brockmann, Sabine Jung‐Klawitter, Stine Christ, Angela M. Kaindl, Anna Tietze, Heiko Krude, Thomas Opladen, Markus Schuelke   +21 more
wiley   +1 more source

The 24-Hour Urinary 5-HIAA: A Simple Test With a Common Pitfall

AACE Clinical Case Reports, 2016
: Objective: 5-Hydroxyindoleacetic acid (5-HIAA) is the principal metabolite of serotonin, and the quantitative urinary excretion of 5-HIAA is the most useful way to diagnose serotonin overproduction by carcinoid tumors.
Margaret L. Burks, MD, Shichun Bao, MD, PhD   +1 more
doaj  

Plasma serotonin precursors and metabolite are correlated with bone mineral density and bone turnover markers in patients with postmenopausal osteoporosis

Journal of Orthopaedic Surgery
Background Serotonin (5-HT) precursors regulate bone remodeling. This study aims to investigate the correlation of plasma 5-HT precursors and metabolite with bone mineral density (BMD) and bone turnover markers in postmenopausal osteoporosis (PMOP ...
Qinying Feng, Xiaoyu Song, Li Liu, Xinzhong Zhou, Zhihao Chen   +4 more
doaj   +1 more source

Genetic association of nucleus accumbens 5-hydroxyindoleacetic acid level and alcohol preference drinking in a quasi-congenic male mice: Potential modulation by Grm7 gene polymorphism

Drug and Alcohol Dependence Reports, 2022
Objective: To test the hypothesis that predisposition to high alcohol drinking behavior is genetically associated with hypoactive serotonergic function in the Nucleus Accumbens (NAc).
Csaba Vadasz, Beatrix M. Gyetvai
doaj  

European Consensus on Malabsorption—UEG & SIGE, LGA, SPG, SRGH, CGS, ESPCG, EAGEN, ESPEN, and ESPGHAN. Part 1: Definitions, Clinical Phenotypes, and Diagnostic Testing for Malabsorption

United European Gastroenterology Journal, Volume 13, Issue 4, Page 599-613, May 2025.
ABSTRACT Malabsorption is a complex and multifaceted condition characterised by the defective passage of nutrients into the blood and lymphatic streams. Several congenital or acquired disorders may cause either selective or global malabsorption in both children and adults, such as cystic fibrosis, exocrine pancreatic insufficiency (EPI), coeliac ...
Marco Vincenzo Lenti, Heinz Florian Hammer, Ilja Tacheci, Rosa Burgos, Stephane Schneider, Anastasiou Foteini, Aleksejs Derovs, Jutta Keller, Ilse Broekaert, Marianna Arvanitakis, Dan Lucian Dumitrascu, Oscar Segarra‐Cantón, Željko Krznarić, Juris Pokrotnieks, Gonçalo Nunes, Johann Hammer, Loris Pironi, Marc Sonyi, Cristina Maria Sabo, Juan Mendive, Adrien Nicolau, Jernej Dolinsek, Denisa Kyselova, Lucrezia Laterza, Antonio Gasbarrini, Teodora Surdea‐Blaga, Jorge Fonseca, Christos Lionis, Gino Roberto Corazza, Antonio Di Sabatino   +29 more
wiley   +1 more source

B-206 The Determination of Vanillylmandelic Acid (VMA), Homovanillic Acid (HVA) and 5-Hydroxyindolacetic Acid (5-HIAA) by LC-Ms/MS Assay in Urine Samples for Diagnosis of Neuroendocrynes Tumors [PDF]

, 2023
Lovaco Castellano F, B F Paulo, Danielle Alves Gomes Zauli   +2 more
openalex   +1 more source

Results of Surgical Reintervention After Suboptimal Initial Resection for Locoregional Neuroendocrine Tumors of the Small Intestine

World Journal of Surgery, Volume 49, Issue 5, Page 1343-1350, May 2025.
Complete resection is the only chance for cure in small intestine neuroendocrine neoplasms (SI‐NEN). Previous ENETS guidelines proposed standards for the surgery of SI‐NEN, which should be followed to provide long‐term disease‐free survival. ABSTRACT Background Complete resection is the only chance for cure in small intestine neuroendocrine neoplasms ...
Detlef K. Bartsch, Norman Krasser‐Gercke, Moritz Jesinghaus, Jannis Görlach, Frederike Eilsberger, Anja Rinke, Elisabeth Maurer   +6 more
wiley   +1 more source