Results 241 to 250 of about 344,978 (286)

Context-dependent roles of 5-HT and its receptors in tumor growth and wound healing: Mechanisms and therapeutic implications. [PDF]

Chin J Cancer Res
Zeng Q, Zhu J, He Z, Qin H, Zhou W, Hua F, Yang J.   +6 more
europepmc   +1 more source

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

Mesenchymal stem cell-derived apoptotic vesicles regulate irritable bowel syndrome in mice via the 5-HT brain-gut axis. [PDF]

Stem Cell Res Ther
Sun Y, Wu D, Lu L, Wang J, Li X, Mao X, Zhang Y.   +6 more
europepmc   +1 more source

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

Restraint Stress Disrupted Intestinal Homeostasis via 5-HT/HTR7/Wnt/β-Catenin/NF-kB Signaling. [PDF]

Int J Mol Sci
Yu J, Wang Z, Chen Y, Dong Y.
europepmc   +1 more source

Correlation study of 5-HT in brain with cognitive function and anxious-like behavior in APP/PS1 transgene mice. [PDF]

Sleep Biol Rhythms
Yuan L, An L, Xie R, Cai J, Li D, Chen X, Guo W, Lin Y, Zhu C, Chang Y, Wang K, Han W, Han L.   +12 more
europepmc   +1 more source

TLR4 interaction with PIEZO1 facilitates the 5-HT-mediated intestinal motility dysfunction in offspring mice induced by LPS exposure during pregnancy. [PDF]

Genes Dis
Luo R, Miao Y, Hu R, Lin F, Yan J, Yang T, Xiao L, Sun Z, Wang Y, Chen J.   +9 more
europepmc   +1 more source

Serotonin 5-HT_2A and 5-HT_2C receptors differentially modulate the acquisition and expression of voluntary alcohol drinking in male mice. [PDF]

Front Neurosci
Simões SC, Amorim LN, Serra YA, Abreu CS, Santana MCE, Leite JPC, Kaneto CM, Costa RCA, Ferreira KR, de Oliveira ICS, Oliveira-Lima AJ, Sulima A, Rice KC, Marinho EAV, Berro LF.   +14 more
europepmc   +1 more source

The role of 5-HT modulation in opioid withdrawal and neonatal opioid withdrawal syndrome: mechanisms and potential serotonergic targets. [PDF]

Expert Opin Investig Drugs
Lam K, Peltz G, Kraft WK.
europepmc   +1 more source

Cell types and neuronal genetic architecture in the rat CSF-contacting nucleus and the role of 5-HT in this nucleus in mediating morphine addiction through the brain-CSF circuit. [PDF]

Front Neurosci
Li Y, Gui B, Zhang Y, Zhang L.
europepmc   +1 more source