Results 251 to 260 of about 284,594 (312)
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Quinpirole — A 5-HT receptor antagonist?
Neuroscience Letters, 1991The rate of brain monoamine synthesis was estimated in the rat by measuring the accumulation of dihydroxyphenylalanine (DOPA) and 5-hydroxytryptophan (5-HTP) following inhibition of cerebral aromatic amino acid decarboxylase by NSD-1015 (475 mumol/kg, i.p., 30 min before decapitation).
S, Ahlenius +2 more
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Molecular biology of 5-HT receptors
Neuropharmacology, 1994The receptors through which serotonin (5-hydroxytryptamine, 5-HT) produces its effects have been the subject of intense investigation, initially using both in vivo and in vitro pharmacological methods, and later radioligand binding. These approaches allowed a preliminary classification of 5-HT receptors, but the identification on subtypes was limited ...
F G, Boess, I L, Martin
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Molecular biology of 5-HT receptors
Trends in Pharmacological Sciences, 1989Within the past six months, isolation of cDNA or genomic clones has been reported for three 5-HT receptors, the 5-HT1C, 5-HT1A and 5-HT2 subtypes. As members of the G protein receptor superfamily, all three 5-HT receptor clones encode single-subunit proteins containing approximately 450 amino acids arrayed as seven interconnected transmembrane segments.
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Molecular Neuroanatomy of 5-HT Receptors
1991Serotoninergic terminals are found throughout the brain, suggesting an involvement of 5-HT in many brain functions. The effects of 5-HT on a given neuron are dependent on the different types of receptors expressed by this neuron, their location on the neuron and the signal transduction mechanism used. In order to provide information on the localization
PALACIOS J. M +3 more
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Heart 5-HT Receptors. A Novel 5-HT Receptor in Human Atrium
1990Receptors for 5-hydroxytryptamine (5-HT) on myocardial cells differ among species and even among different heart regions of the same species. In molluscs 5-HT enhances heart force and cyclic AMP, and lysergic acid diethylamide (LSD) is a potent agonist. In human atria 5-HT, but not LSD, increases contractile force through unknown receptors (not blocked
Alberto J. Kaumann +5 more
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5-Hydroxytryptamine (5-HT) Receptor Ligands
Current Pharmaceutical Design, 2007Serotonin (5-HT) receptors are part of the G protein-coupled and ligand-gated ion channel families. 5-HT exerts its diverse actions by binding to cell surface receptors which can be classified into seven distinct families (5-HT1 to 5-HT7) according to their structural diversity and mode of action.
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Molecular biology of serotonin (5-HT) receptors
Pharmacology Biochemistry and Behavior, 1991The recent cloning of three types of 5-hydroxytryptamine (5-HT, serotonin) receptors substantiates radioligand-based definitions of 5-HT receptors, and provides a framework in which to understand the function and evolution of the receptors. The primary sequences determined by molecular cloning of the 5-HT1c, 5-HT1a and 5-HT2 receptors place each of ...
J C, Shih, W, Yang, K, Chen, T, Gallaher
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5-HT Receptors: Subtypes and Second Messengers
Journal of Receptor Research, 1991Our knowledge about 5-HT (serotonin, 5-hydroxytryptamine) receptors has gained significantly over the recent few years. The discovery of selective ligands and the use of new techniques have led to a significant increase in the number of recognised receptors subtypes.
D, Hoyer, P, Schoeffter
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Modern 5-HT receptor classification and 5-HT based drugs
Expert Opinion on Investigational Drugs, 1994Based on operational (agonist and antagonist rank order), transductional (second messenger coupling) and structural (gene and amino acid sequence) criteria, the Nomenclature Committee of the Serotonin Club has discerned four distinct 5-HT receptor types, besides two less well characterised categories including some recombinant and the so-called ‘orphan’
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Electrophysiology of 5-HT Receptors
2000Within the past decade, molecular cloning techniques have confirmed that 5-hydroxytryptamine (5-HT) receptor subtypes, originally predicted from radioligand binding and functional studies (e.g., 5-HT1, 5-HT2, 5-HT3, 5-HT4), represent separate and distinct gene products. This knowledge has had a crucial impact on electrophysiological approaches to the 5-
G. K. Aghajanian, R. Andrade
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