Results 31 to 40 of about 125,938 (267)

IFN-γ inhibits 5-HT-induced melanin biosynthesis via downregulation of 5-HT receptors in vivo/in vitro

Journal of Pharmacological Sciences, 2019
Hypopigmentation disorders, such as vitiligo, are difficult for treatment due to complicated pathogenesis, resulting from multiple factors including neural and immune elements. 5-HT and IFN-γ both play crucial roles in these skin diseases.
Minxuan Cai, Liangliang Zhou, Jun Liao, Qiaoling Huang, Zhenjiang Xia, Jing Shang   +5 more
doaj   +1 more source

The Constitutive Activity of Spinal 5-HT₆ Receptors Contributes to Diabetic Neuropathic Pain in Rats

Biomolecules, 2023
Diabetic neuropathy is often associated with chronic pain. Serotonin type 6 (5-HT6) receptor ligands, particularly inverse agonists, have strong analgesic potential and may be new candidates for treating diabetic neuropathic pain and associated co-morbid
Nazarine Mokhtar, Marcin Drop, Florian Jacquot, Sylvain Lamoine, Eric Chapuy, Laetitia Prival, Youssef Aissouni, Vittorio Canale, Frédéric Lamaty, Paweł Zajdel, Philippe Marin, Stéphane Doly, Christine Courteix   +12 more
doaj   +1 more source

Both exogenous 5-HT and endogenous 5-HT, released by fluoxetine, enhance distension evoked propulsion in guinea-pig ileum in vitro

Frontiers in Neuroscience, 2014
The roles of 5-HT3 and 5-HT4 receptors in the modulation of intestinal propulsion by luminal application of 5-HT and augmentation of endogenous 5-HT effects were studied in segments of guinea-pig ileum in vitro. Persistent propulsive contractions evoked
Rachel M Gwynne, Amanda J Clarke, John B Furness, Joel C Bornstein   +3 more
doaj   +1 more source

Dynamics and Patterning of 5-Hydroxytryptamine 2 Subtype Receptors in JC Polyomavirus Entry

Viruses, 2022
The organization and dynamics of plasma membrane receptors are a critical link in virus-receptor interactions, which finetune signaling efficiency and determine cellular responses during infection. Characterizing the mechanisms responsible for the active
Kashif Mehmood, Michael P. Wilczek, Jeanne K. DuShane, Matthew T. Parent, Colleen L. Mayberry, Jaqulin N. Wallace, Francois L. Levasseur, Tristan M. Fong, Samuel T. Hess, Melissa S. Maginnis   +9 more
doaj   +1 more source

Conservation of 5-HT1A receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT homeostasis

Frontiers in Pharmacology, 2013
Firing activity of serotonin (5-HT) neurons in the dorsal raphe nucleus (DRN) is controlled by inhibitory somatodendritic 5-HT1A autoreceptors. This autoinhibitory mechanism is implicated in the etiology of disorders of emotion regulation, such as ...
Naozumi eAraragi, Boris eMlinar, Gilda eBaccini, Lise eGutknecht, Klaus-Peter eLesch, Renato eCorradetti   +5 more
doaj   +1 more source

Hippocampal 5-HT1A receptor and spatial learning and memory

Frontiers in Pharmacology, 2015
Spatial cognition is fundamental for survival in the topographically complex environments inhabited by humans and other animals. The hippocampus, which has a central role in spatial cognition, is characterized by high concentration of serotonin (5 ...
Yifat eGlikmann-Johnston, Yifat eGlikmann-Johnston, Michael Martin Saling, Michael Martin Saling, David C Reutens, Julie C Stout   +5 more
doaj   +1 more source

Influences of 5-hydroxytriptamine on sperm hyperactivation and in vitro fertility in rats

The Journal of Reproduction and Development
The neurotransmitter, 5-hydroxytriptamine (5-HT), is well known. Furthermore, it enhances the acrosome reaction, hyperactivation, and in vitro fertilization (IVF) success in hamsters and mice.
Yuki KOYANO, Masakatsu FUJINOKI
doaj   +1 more source

Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster

Neural Plasticity, 2016
Serotonin modulates various physiological processes and behaviors. This study investigates the role of 5-HT in locomotion and feeding behaviors as well as in modulation of sensory-motor circuits.
Zana R. Majeed, Esraa Abdeljaber, Robin Soveland, Kristin Cornwell, Aubrey Bankemper, Felicitas Koch, Robin L. Cooper   +6 more
doaj   +1 more source

Serotonin augments gut pacemaker activity via 5-HT3 receptors. [PDF]

PLoS ONE, 2011
Serotonin (5-hydroxytryptamine: 5-HT) affects numerous functions in the gut, such as secretion, muscle contraction, and enteric nervous activity, and therefore to clarify details of 5-HT's actions leads to good therapeutic strategies for gut functional ...
Hong-Nian Liu, Susumu Ohya, Yuji Nishizawa, Kenta Sawamura, Satoshi Iino, Mohsin Md Syed, Kazunori Goto, Yuji Imaizumi, Shinsuke Nakayama   +8 more
doaj   +1 more source

Effects of 5-hydroxytryptamine on spermatozoal hyperactivation and in vitro fertilization in mice

The Journal of Reproduction and Development, 2019
In this study, we examined the effects of 5-hydroxytryptamine (5-HT) on the motility and hyperactivation of mouse spermatozoa. In addition, we examined whether 5-HT increases the success of in vitro fertilization (IVF) in mice.
Yukiko SUGIYAMA, Masakatsu FUJINOKI, Hiroaki SHIBAHARA   +2 more
doaj   +1 more source