Results 71 to 80 of about 199,847 (309)

Varenicline Interactions at the 5-HT3 Receptor Ligand Binding Site are Revealed by 5-HTBP. [PDF]

, 2015
Cys-loop receptors are the site of action of many therapeutic drugs. One of these is the smoking cessation agent varenicline, which has its major therapeutic effects at nicotinic acetylcholine (nACh) receptors but also acts at 5-HT3 receptors.
Lillestol, Reidun K, Lummis, Sarah CR, Price, Kerry L, Ulens, Chris   +3 more
core   +3 more sources

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

The Effects of Serotonin Receptor Antagonists on Contraction and Relaxation Responses Induced by Electrical Stimulation in the Rat Small Intestine [PDF]

, 2014
Background: The main source of 5-HT in body is in enterchromafin cells of intestine, different studies mentioned different roles for endogenous 5-HT and receptors involved and it is not clearified the mechanism of action of endogenous 5-HT. Objectives:
Bianchi C, Broad RM, Buchheit KH, Budhoo MR, Carter D, Costall B, Costa M, Craig DA, D'Amato M, Eglen RM, Engel G, Erspamer V, Feldberg W, Gale JD, Gebauer A, Gershon MD, Gozlan H, Hedge SS, Hume SP, Humphrey PP, Ivancheva C, Javid FA, Kilbinger H, Kuemmerle JF, Leysen JE, Malleron JL, Mawe GM, Nowak TV, Pan H, Racke K, Radomirov R, Satoh Y, Weber LJ, Yamamoto I   +33 more
core   +1 more source

Life‐Threatening Bradycardia in Anti‐NMDA‐Receptor Encephalitis and a Novel Use for Permanent Pacing

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Pediatric anti‐NMDA receptor encephalitis (pNMDARE) is an autoantibody‐mediated disorder that can cause severe autonomic dysfunction, including symptomatic bradycardia and asystole. Dysautonomia can last for years, making it very challenging to manage.
Sarah Tucker, Abhijit Das, Andres Jimenez, Areeba Basit, Yike Jiang, Emily A. Smitherman, Heather Van Mater, Taylor Howard, Alexander J. Sandweiss, Kristen S. Fisher   +9 more
wiley   +1 more source

Role of 5-HT_1A and 5-HT₇ Receptors in Memory Regulation and the Importance of Their Coexpression: A Systematic Review

Biomolecules
The 5-HT1A and 5-HT7 receptors play a key role in regulating cognitive processes and have been widely linked to the pathophysiology of depression, anxiety, and schizophrenia—disorders often associated with memory impairment.
Alfredo Briones-Aranda, Daniela Flores-Durán, Rodrigo Romero-Nava, Josselin Carolina Corzo-Gómez, Refugio Cruz-Trujillo, Floribert Toalá-Sepúlveda, Blanca E. Del-Río-Navarro, Fengyang Huang   +7 more
doaj   +1 more source

Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network. [PDF]

PLoS ONE, 2011
Neurons of the respiratory network in the lower brainstem express a variety of serotonin receptors (5-HTRs) that act primarily through adenylyl cyclase.
Marcus Niebert, Steffen Vogelgesang, Uwe R Koch, Anna-Maria Bischoff, Miriam Kron, Nathalie Bock, Till Manzke   +6 more
doaj   +1 more source

Zebrafish studies identify serotonin receptors mediating antiepileptic activity in Dravet syndrome. [PDF]

, 2019
Dravet syndrome is a life-threatening early-onset epilepsy not well controlled by antiepileptic drugs. Drugs that modulate serotonin (5-HT) signalling, including clemizole, locaserin, trazodone and fenfluramine, have recently emerged as potential ...
Baraban, Scott C, Grandjean, Jean-Marc, Griffin, Aliesha L, Jaishankar, Priyadarshini, Olson, Steven H, Renslo, Adam R   +5 more
core   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Nicotinic receptors [PDF]

, 2014
Regulation of normal or abnormal behaviour is critically controlled by the central serotonergic systems. Recent evidence has suggested that serotonin (5-HT) neurotransmission dysfunction contributes to a variety of pathological conditions, including ...
A Auclair, A Beyeler, A Coppen, A Dahlstrom, A Fletcher, A Fletcher, A Gobert, A Jain, A Markou, A Pazos, AC Farley, AJ Grottick, AJ Grottick, AM Batman, AS Brown, AV Prochazka, B Chang, B Lendvai, BB Brodie, BL Jacobs, BM Twarog, BR Cooper, C Cirillo, C Nocjar, C Reperant, CP Müller, D Herve, D Hoyer, D Hoyer, D Kooy van der, D Quarta, DE Nichols, DJ Balfour, DJ Hayes, DL Murphy, DL Willins, DM Tomkins, DV Herin, E Costa, E Esposito, E Quattrocki, EB Ribeiro, EC Azmitia, ED Levin, ED Levin, EJ Bockstaele Van, EJ Bockstaele Van, EJ Mills, F Jenck, G Chevalier, G Chiara Di, G Cucchiaro, G Cucchiaro, G Engberg, G Giovanni Di, G Giovanni Di, G Giovanni Di, G Giovanni Di, G Giovanni Di, G Giovanni Di, G Giovanni Di, G Giovanni Di, G Porras, G Porras, GA Higgins, GA Higgins, GA Higgins, GA Kennett, GA Kennett, GF Koob, GW Dalack, H Khalki, H Moukhles, H Rollema, H Rollema, H Rollema, H Takahashi, HD Mansvelder, J Arnt, J Dong, J Hannon, JA Ascher, JE Anderson, JE Slemmer, JF Cryan, JH Thompson, JK Abrams, JL Neisewander, JR Martin, JW Coe, K Guillem, K Touiki, KD Alex, KG Baker, KH Thomas, KJ Clemens, KL Summers, L Galindo-Charles, L Pozzi, LA Pockros, LL McMahon, M Bubser, M Costa, M Dols, M Giorgetti, M Pierucci, M Pompeiano, M Reuben, M Zaniewska, M Zaniewska, M Zaniewska, MD Doherty, ME Benwell, MF O'Neill, MJ Bubar, MJ Bubar, MJ Eisenberg, MJ Millan, MM Rapport, N Corvaja, N Maurice, NA Rigotti, NB Edwards, NG Schneider, NM Barnes, OT Phillipson, P Deurwaerdere De, P Deurwaerdere De, P Enkhbaatar, P Olausson, P Olausson, P Seth, PA Crooks, PBS Clarke, PH Hutson, PJ Fletcher, PJ Fletcher, PJ Fletcher, PJ Kenny, PJ Kenny, PM Whitaker-Azmita, RD Schwartz, RF Mucha, RM Bowker, RM Bowker, RS Bitner, RS Bitner, S Hjorth, S Mihailescu, S Navailles, S Prisco, SG Matta, SJ Bonasera, SM Hall, SM Hall, SP Ji, SP Ranade, TA Shahan, V Cornea-Hébert, V Erspamer, V Hillegaart, V Matteo Di, V Matteo Di, V Matteo Di, V Matteo Di, V Matteo Di, V Matteo Di, V Matteo Di, W Feldberg, WA Corrigall, X Li, Y Takada, Z Ma, ZJ Yu   +173 more
core   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source