Results 71 to 80 of about 87,483 (259)

Recent Advances in Ferrite‐Based Materials for Biomedical Applications: A Comprehensive Review

open access: yesAdvanced Materials, EarlyView.
Ferrite nanoplatforms are presented as tunable biomedical materials in which synthesis control, cation engineering, defect/morphology regulation, and surface functionalization govern structure–property–bioactivity relationships. These design strategies enable multifunctional applications including MRI contrast, magnetic hyperthermia, targeted drug ...
Pramod D. Mhase   +6 more
wiley   +1 more source

Presynaptic selectivity of a ligand for serotonin 1A receptors revealed by in vivo PET assays of rat brain.

open access: yesPLoS ONE, 2012
A novel investigational antidepressant with high affinity for the serotonin transporter and the serotonin 1A (5-HT(1A)) receptor, called Wf-516 (structural formula: (2S)-1-[4-(3,4-dichlorophenyl)piperidin-1-yl]-3-[2-(5-methyl-1,3,4-oxadiazol-2-yl)benzo[b]
Takeaki Saijo   +10 more
doaj   +1 more source

1‐D Collocated Dual‐Gradient Sensory Fibers for Comprehensive Sensing and Decoding of Complex Human Motion and Physiology

open access: yesAdvanced Materials, EarlyView.
Coupled materials design enables a monolithic fiber that integrates complementary sensing regimes into a single wearable strand. By preserving informative signal features across subtle physiological deformation, large body motion, and mixed mechanical inputs, the dual‐gradient architecture generates synchronized, less redundant outputs that improve ...
Yunheum Lee   +13 more
wiley   +1 more source

SERAAK2 as a Serotonin Receptor Ligand: Structural and Pharmacological In Vitro and In Vivo Evaluation

open access: yesMolecules
Serotonin receptors, in particular 5-HT1A and 5-HT2A receptors, are important molecular targets for the central nervous system (CNS) disorders, such as schizophrenia, depression, anxiety disorders, memory deficits, and many others.
Agnieszka A. Kaczor   +7 more
doaj   +1 more source

5-HT Receptors and the Development of New Antidepressants. [PDF]

open access: yesInt J Mol Sci, 2021
Ślifirski G, Król M, Turło J.
europepmc   +1 more source

Intrinsically Stretchable Piezoelectric Nanocomposites for Artificial Ultrasonic Sensory Synapse

open access: yesAdvanced Materials, EarlyView.
Applying ultrasonic stimulations to a soft‐stretchable underwater piezoelectric sensor based on the soft‐stretchable nanocomposite from the thermal cross‐linking between the ─C─F group of P(VDF‐TrFE) and the ─NH2 group of (PEG‐diamine) with incorporating amine‐terminated BTO@APTES nanofillers on the soft PDMS substrates generated high piezoelectric ...
Trung Dieu Do   +11 more
wiley   +1 more source

Additive‐Manufactured, Multifunctional Bioreactor Technology for Dynamic Culture of 3D Bioprinted Tissue Models

open access: yesAdvanced Materials Technologies, EarlyView.
We introduce an additively manufactured bioreactor with a perfusion flow system and integrated temperature and pH sensors for skeletal muscle tissue biofabrication. The bioreactor's performance was evaluated by assessing the viability, spreading of the myoblast cells in a printed scaffold, and contraction of the isolated murine musculi interossei ...
Lys Sprenger   +9 more
wiley   +1 more source

IFN-γ inhibits 5-HT-induced melanin biosynthesis via downregulation of 5-HT receptors in vivo/in vitro

open access: yesJournal of Pharmacological Sciences, 2019
Hypopigmentation disorders, such as vitiligo, are difficult for treatment due to complicated pathogenesis, resulting from multiple factors including neural and immune elements. 5-HT and IFN-γ both play crucial roles in these skin diseases.
Minxuan Cai   +5 more
doaj   +1 more source

Extrusion Bioprinting for Wound Healing: Innovations in Functionalized Bioinks and Bioprinting Technology

open access: yesAdvanced Materials Technologies, EarlyView.
Extrusion‐based bioprinting (EBB) has emerged as a versatile biofabrication platform capable of precisely depositing bioinks composed of biomaterials, cells, and bioactive agents to generate patient‐specific, biomimetic skin constructs. This paper presents a state‐of‐the‐art and forward‐looking overview of EBB for wound healing, encompassing printing ...
Hien‐Phuong Le   +4 more
wiley   +1 more source

Nitroso-oxidative stress after activation of 5-HT4 receptors under conditions of colitis in rats

open access: yesCurrent Issues in Pharmacy and Medical Sciences, 2019
Serotonin (5-hydroxytryptamine, 5-HT) plays an important role in the regulation of the functioning of the gastrointestinal tract, including that of the colon. The response of smooth muscles, blood vessels and colon mucosa (CM) to 5-HT is realized through
Denysenko Nataliya   +3 more
doaj   +1 more source

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