Results 91 to 100 of about 199,847 (309)

A Surface‐engineered Microfluidic Device for Antibody‐Mediated Negative Selection of High‐Quality Sperm for Assisted Reproduction

Advanced Functional Materials, EarlyView.
This study reports a microfluidic device with a functionalized surface utilizing a polyoxazoline coating and covalently immobilized gold nanoparticles and anti‐phosphatidylserine antibody. The device efficiently eliminates pre‐apoptotic and apoptotic spermatozoa and yields sperm with substantially improved quality and low DNA damage, offering a simple ...
Soraya Rasi Ghaemi, David J. Sharkey, Nicole O. McPherson, Markos Negash Alemie, Krasimir Vasilev, Sarah A. Robertson   +5 more
wiley   +1 more source

Constitutively active 5-HT receptors: An explanation of how 5-HT antagonists inhibit gut motility in species where 5-HT is not a enteric neurotransmitter ?

Frontiers in Cellular Neuroscience, 2015
Antagonists of 5-Hydroxytryptamine (5-HT) receptors are well known to inhibit gastrointestinal (GI)-motility and transit in a variety of mammals, including humans.
Nick eSpencer
doaj   +1 more source

Understanding the molecular pharmacology of the serotonergic system : using fluoxetine as a model [PDF]

, 2011
Objectives: Serotonin is a monoamine neurotransmitter that is widely distributed in the body and plays an important role in a variety of psychological and other body functions such as mood, sexual desire and function, appetite, sleep, memory and learning,
Mifsud, Janet, Sghendo, Lino
core   +1 more source

RNA‐Micelles as Self‐Assembling Structures for Efficient Co‐Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis

Advanced Functional Materials, EarlyView.
Two kinds of self‐assembled RNA micelles were used to co‐deliver synergistic siRNA and nucleoside analogues for the treatment of colorectal cancer lung metastases. Near‐complete elimination of lung cancer metastases was confirmed in an orthotopic lung metastasis model constructed using human colorectal cancer lung metastases patient surgical samples to
Kai Jin, Piotr Rychahou, Daniel W. Binzel, B. Mark Evers, Peixuan Guo   +4 more
wiley   +1 more source

The stimulating effects of ethanol on ventral tegmental area dopamine neurons projecting to the ventral pallidum and medial prefrontal cortex in female Wistar rats: regional difference and involvement of serotonin-3 receptors [PDF]

, 2011
RATIONALE: The ventral tegmental area (VTA) mediates the local stimulating effects of ethanol (EtOH) in a region-dependent manner, with EtOH administration in the posterior but not anterior VTA stimulating the mesolimbic system.
Ding, Zheng-Ming, Engleman, Eric A., Hall, Sarah R., Hauser, Sheketha R., McBride, William J., Oster, Scott M., Rodd, Zachary A.   +6 more
core   +1 more source

Conductance‐Dependent Photoresponse in a Dynamic SrTiO3 Memristor for Biorealistic Computing

Advanced Functional Materials, EarlyView.
A nanoscale SrTiO3 memristor is shown to exhibit dynamic synaptic behavior through the interaction of local electrical and global optical signals. Its photoresponse depends quantitatively on the conductance state, which evolves and decays over tunable timescales, enabling ultralow‐power, biorealistic learning mechanisms for advanced in‐memory and ...
Christoph Weilenmann, Hanglin He, Marko Mladenović, Till Zellweger, Kevin Portner, Klemens Bauer, Guillaume Bellec, Mathieu Luisier, Alexandros Emboras   +8 more
wiley   +1 more source

Serotonin-3 Receptors in the Posterior Ventral Tegmental Area Regulate Ethanol Self-Administration of Alcohol-Preferring (P) Rats [PDF]

, 2010
Several studies indicated the involvement of serotonin-3 (5-HT 3 ) receptors in regulating alcohol- drinking behavior. The objective of this study was to determine the involvement of 5-HT 3 receptors within the ventral tegmental area (VTA) in ...
Beardsley, Campbell, Carboni, Ding, Ding, Fadda, Ford, Gatto, Herve, Hodge, Hodge, Hodge, Ikemoto, Ikemoto, Ikemoto, Ikemoto, James M. Murphy, Jamie E. Toalston, Katner, Klein, Knapp, Koob, Liu, Liu, Lovinger, McKinzie, McKinzie, Minabe, Nowak, Nowak, Paxinos, Prisco, Rasmussen, Richard L. Bell, Rodd, Rodd, Rodd, Rodd, Rodd, Rodd, Rodd-Henricks, Rodd-Henricks, Rodd-Henricks, Scott M. Oster, Sung, Svensson, Toalston, Tomkins, Tylene J. Pommer, Van Bockstaele, William J. McBride, Wozniak, Zachary A. Rodd   +52 more
core   +1 more source

VIVID: A qPCR‐Based Platform for Sensitive and Quantitative In Vivo Tracking of Extracellular Vesicles

Advanced Functional Materials, EarlyView.
This study introduces VIVID (Vesicle In Vivo Identification using DNA), a qPCR‐based platform that tracks PCR‐amplifiable DNA tags loaded in the EVs for accurate and quantifiable EV biodistribution in vivo. ABSTRACT Extracellular vesicles (EVs) represent promising carriers for nucleic acid therapeutics, offering advantages over synthetic nanoparticles ...
Oscar Boyadjian, Talin Ebrahimian, Jonathan Miranda O'Connor, Janusz Rak, Stephanie Lehoux, Maryam Tabrizian   +5 more
wiley   +1 more source

Post Natal Impact of Maternal Tryptophan Deficiency on Central CO2/PH Chemosensitivity [PDF]

, 2012
Cells and mechanisms underlying central chemosensitivity, are poorly understood and can be controversial. Our overarching hypothesis is that brainstem 5-HT and/or GABA neurons contribute to detection and response to changes in pH/CO2. Our experiments are
Mosher, Bryan P.
core  

The 5-HT7 receptor as a potential target for treating drug and alcohol abuse [PDF]

, 2015
Alcohol and drug abuse take a large toll on society and affected individuals. However, very few effective treatments are currently available to treat alcohol and drug addiction.
Bell, Richard L., Engleman, Eric A., Hauser, Sheketha R., Hedlund, Peter B., Roberts, Amanda J., Sari, Youssef   +5 more
core   +2 more sources