Results 91 to 100 of about 12,268,158 (295)
PLoS ONE, 2012 A novel investigational antidepressant with high affinity for the serotonin transporter and the serotonin 1A (5-HT(1A)) receptor, called Wf-516 (structural formula: (2S)-1-[4-(3,4-dichlorophenyl)piperidin-1-yl]-3-[2-(5-methyl-1,3,4-oxadiazol-2-yl)benzo[b]
Takeaki Saijo +10 more
doaj +1 more source
Advanced Materials Interfaces, EarlyView.Providing mechanically robust structural color coating technology inspired by cooperative interactions in nature. The spatial arrangement of melanin particles within the keratin matrix generates angle‐independent structural colors. Diverse functional groups in keratin and melanin contribute to interparticle and substrate adhesion, resulting in the ...
Taisei Harada +12 more
wiley +1 more source
MoleculesSerotonin receptors, in particular 5-HT1A and 5-HT2A receptors, are important molecular targets for the central nervous system (CNS) disorders, such as schizophrenia, depression, anxiety disorders, memory deficits, and many others.
Agnieszka A. Kaczor +7 more
doaj +1 more source
5-HT Receptors and the Development of New Antidepressants. [PDF]
Int J Mol Sci, 2021 Ślifirski G, Król M, Turło J.
europepmc +1 more source
Advanced Robotics Research, EarlyView.A soft robotic simulator is developed to replicate the digital removal of feces (DRF), a sensitive yet essential nursing procedure. Integrating soft actuators, sensors, and a realistic rectal model, the simulator balances functional fidelity with perceptual realism. Engineering evaluations and nurse feedback confirm its potential to enhance training in
Shoko Miyagawa +10 more
wiley +1 more source
From Rigid to Soft Robotic Approaches for Neuroendoscopy
Advanced Robotics Research, EarlyView.Robotic assistance has had minimal impact on deep intraventricular surgeries, where small‐scale, precision, and reduced invasiveness can contribute to improved patient outcomes. Emerging technologies in rigid, soft, and hybrid robotics are reviewed to identify the most promising mechanisms for deep brain navigation in addition to an attempt to identify
Kieran Gilday +3 more
wiley +1 more source
Journal of Pharmacological Sciences, 2019 Hypopigmentation disorders, such as vitiligo, are difficult for treatment due to complicated pathogenesis, resulting from multiple factors including neural and immune elements. 5-HT and IFN-γ both play crucial roles in these skin diseases.
Minxuan Cai +5 more
doaj +1 more source
Atomic Tuning of Metal‐Support Interactions for Pathway‐Selective CO2 Photoreduction on TiO2
Advanced Science, EarlyView.Single‐atom Fe and Cu catalysts anchored on TiO2 steer photocatalytic CO2 reduction toward distinct pathways. Fe sites favor rapid *CO desorption and selective CO formation, whereas Cu sites stabilize *CHO intermediates, enabling deep reduction and C─C coupling. Combined spectroscopy and DFT calculations reveal how metal–support interactions and oxygen
Dongyun Kim +13 more
wiley +1 more source
Nitroso-oxidative stress after activation of 5-HT4 receptors under conditions of colitis in rats
Current Issues in Pharmacy and Medical Sciences, 2019 Serotonin (5-hydroxytryptamine, 5-HT) plays an important role in the regulation of the functioning of the gastrointestinal tract, including that of the colon. The response of smooth muscles, blood vessels and colon mucosa (CM) to 5-HT is realized through
Denysenko Nataliya +3 more
doaj +1 more source
Frontiers in Neural Circuits, 2014 Layer 5 pyramidal neurons (L5PNs) in the mouse prefrontal cortex respond to serotonin (5-HT) according to their long-distance axonal projections; 5-HT1A (1A) receptors mediate inhibitory responses in corticopontine (CPn) L5PNs, while 5-HT2A (2A ...
Emily K Stephens +5 more
doaj +1 more source