Associations of the serotonin transporter gene polymorphism, 5-HTTLPR, and adverse life events with late life depression in the elderly Lithuanian population [PDF]
Scientific Reports, 2023 Late-life depression (LLD) is a multifactorial disorder, with susceptibility and vulnerability potentially influenced by gene-environment interaction. The aim of this study was to investigate whether the 5-HTTLPR polymorphism is associated with LLD.
Sandrita Simonyte +6 more
doaj +2 more sources
Inhibitory control mediates the interaction between serotonin transporter gene (5-HTTLPR) and peer victimization on adolescent depressive symptoms [PDF]
Scientific Reports, 2021 Many efforts have been devoted to investigating the effect of the interaction between the serotonin transporter gene (5-HTTLPR) and environment (G × E) on depression, but they yield mixed results. The inconsistency has suggested that G × E effects may be
Xiaonan Lin +3 more
doaj +2 more sources
Time moderates the interplay between 5-HTTLPR and stress on depression risk: gene x environment interaction as a dynamic process [PDF]
Translational Psychiatry, 2022 The serotonin-transporter-linked promoter region (5-HTTLPR) has been widely investigated as contributing to depression vulnerability. Nevertheless, empirical research provides wide contrasting findings regarding its involvement in the etiopathogenesis of
Claudia Delli Colli +8 more
doaj +2 more sources
Molecular genetic associations between a prominent serotonin transporter gene polymorphism (5‐HTTLPR/rs25531) and individual differences in tendencies toward autistic traits and generalized internet use disorder in China and Germany [PDF]
Brain and Behavior, 2022 Background The serotonin transporter polymorphism 5‐HTTLPR is an extensively investigated genetic marker of autistic traits or autism spectrum disorder, and recently has also been studied in the realm of internet use disorder (IUD), yet the findings ...
YingYing Zhang +5 more
doaj +2 more sources
Association of 5-HTTLPR With Post-Traumatic Stress Disorder in US Service Members [PDF]
Chronic StressObjective Post-traumatic stress disorder (PTSD) is a mental disorder that manifests after exposure to a stressful traumatic event, such as combat experience. Accumulated evidence indicates an important genetic influence in the development of PTSD.
Xian-Zhang Hu +5 more
doaj +2 more sources
Frontiers in Psychiatry, 2019 Background: Recently, many case-control studies have reported the association between 5-HTTLPR polymorphism and autism risk. However, the results are inconclusive and conflicting. To investigate the genetic association of 5-HTTLPR polymorphism and autism
Xiaotang Fan, Junwei Gao
exaly +3 more sources
Annals of Indian Psychiatry, 2021 Serotonin transporter-linked polymorphic regions (5-HTTLPR) have been investigated intensively in suicide with inconsistent findings. However, a recent meta-analysis has observed an association of S allele with violent attempted suicide.
Bisu Singh
doaj +1 more source
An examination of the association between 5-HTTLPR, combat exposure, and PTSD diagnosis among U.S. veterans. [PDF]
PLoS ONE, 2015 To examine the association between the 5-HTTLPR polymorphism of the serotonin transporter (SLC6A4) gene, combat exposure, and posttraumatic stress disorder (PTSD) diagnosis and among two samples of combat-exposed veterans.The first sample included 550 ...
Yutao Liu +8 more
doaj +1 more source
Mediterranean Journal of Clinical Psychology, 2021 Background: The identification of relationship between genes and emotional distress mediated by personality traits among high level athletes may help to implement specific clinical psychology programs. Findings suggest that 5-HTTLPR genetic polymorphisms
Annamaria Petito +8 more
doaj +1 more source
The 5-HTTLPR confers susceptibility to anorexia nervosa in Han Chinese: evidence from a case-control and family-based study. [PDF]
PLoS ONE, 2015 Accumulating evidence has implied that serotonin system dysfunction may be involved in the etiology of anorexia nervosa (AN). Serotonin-transporter-linked promoter region (5-HTTLPR) polymorphism is the genetic variant coding for the serotonin transporter
Jue Chen +6 more
doaj +1 more source