Results 41 to 50 of about 79,000,091 (170)

Genetic variants of SLC6A4 and risk of coronary artery disease: insights from North Indian population

Orphanet Journal of Rare Diseases
Background The activity of SLC6A4 is influenced by its polymorphisms, including the length variation in serotonin transporter linked promoter region (5-HTTLPR), a single nucleotide polymorphism (rs25531), and variable number of tandem repeats in ...
Jyotdeep Kour Raina, Minakashee Sharma, Ravi Sharma, Rohit Bhardwaj, Parvinder Kumar, Santasree Banerjee, Rakesh Kumar Panjaliya   +6 more
doaj   +1 more source

Şizofrenili hastalarda serotonin taşıyıcı gen polimorfizmi

Psychiatry and Clinical Psychopharmacology, 2021
Şizofrenili hastalarda serotonin taşıyıcı gen polimorfizmi Amaç: Serotonin taşıyıcı (5-HTT) gen, polimorfik yapıda bir gen olup serotoninin taşınmasındaki rolü nedeniyle psikiyatrik bozuklukların etyolojisinde önemli bir rol oynadığı öne sürülmektedir.
Author Name Surname
doaj  

Hydroxytryptamine transporter gene-linked polymorphic region (5HTTLPR) is associated with delusions in Alzheimer’s disease

Translational Neurodegeneration, 2019
Background Serotoninergic pathways underlying delusion symptoms in Alzheimer’s disease (AD) have not been fully clarified. 5-Hydroxytryptamine transporter gene-linked polymorphic region (5-HTTLPR) is a variable number tandem repeats in the promoter ...
Grazia D’Onofrio, Francesco Panza, Daniele Sancarlo, Michele Lauriola, Mariangela P. Dagostino, Giulia Paroni, Madia Lozupone, Antonio Mangiacotti, Paola Bisceglia, Carolina Gravina, Maria Urbano, Filomena Addante, Francesco Paris, Leandro Cascavilla, Antonio Greco, Davide Seripa   +15 more
doaj   +1 more source

Comparative Analysis of Antidepressant Mechanisms and Side Effects: Network Pharmacology and Molecular Docking Study of Amitriptyline, Mirtazapine, and Escitalopram for Treating Major Depressive Disorder

Depression and Anxiety, Volume 2026, Issue 1, 2026.
Background Amitriptyline, mirtazapine, and escitalopram are effective antidepressants for treating major depressive disorder (MDD). Our study aimed to use computational biology to understand the mechanisms for the similarities and differences in efficacies and side effects of these drugs.
Chuanjun Zhuo, Qiuyu Zhang, Haitao Song, Jiatong Zou, Ranli Li, Xiaoyan Ma, Ximing Chen, Yachen Li, Lei Yang, Lina Wang, Chao Li, Hongjun Tian   +11 more
wiley   +1 more source

The influence of 5-HTTLPR transporter genotype on amygdala-subgenual anterior cingulate cortex connectivity in autism spectrum disorder

Developmental Cognitive Neuroscience, 2017
Social deficits in autism spectrum disorder (ASD) are linked to amygdala functioning and functional connection between the amygdala and subgenual anterior cingulate cortex (sACC) is involved in the modulation of amygdala activity.
Francisco Velasquez, Jillian Lee Wiggins, Whitney I. Mattson, Donna M. Martin, Catherine Lord, Christopher S. Monk   +5 more
doaj   +1 more source

Association Study on Multi‐Timepoint DNA Methylation Levels of Serotonin Transporter Gene and Adolescent Psychological‐Behavioral Development

Neuropsychopharmacology Reports, Volume 45, Issue 4, December 2025.
We examined multi‐timepoint DNA methylation levels of the SLC6A4 gene using saliva samples collected at ages 11, 13, and 15, and their association with psycho‐behavioral clusters. Lower methylation levels were associated with externalizing problems in males. ABSTRACT Aims This study aimed to investigate whether multi‐timepoint DNA methylation levels at
Tempei Ikegame, Miki Bundo, Daiki Nagaoka, Yutaro Yanagida, Yutaka Nakachi, Emi Kiyota, Naohiro Okada, Shinsuke Koike, Syudo Yamasaki, Shuntaro Ando, Atsushi Nishida, Kazuya Iwamoto, Kiyoto Kasai   +12 more
wiley   +1 more source

5-HTTLPR, victimization and ecological executive function of adolescents

, 2016
Executive function (EF) plays an important role in guiding peer relationship, school performance and behavior control. Children exposed to traumatic environments have been reported to perform poorer in EF tasks.
Li, P, Lou, F, Liu, J, Lavebratt, C, Cao, F   +4 more
core   +1 more source

5-HTTLPR-environment interplay and its effects on neural reactivity in adolescents. [PDF]

, 2012
It is not known how 5-HTTLPR genotype x childhood adversity (CA) interactions that are associated with an increased risk for affective disorders in population studies operate at the neural systems level.
Kerslake, William S, Hiscox, Lucy V., Calder, Andrew J, Goodyer, Ian M., Walsh, Nicholas D, Ewbank, Michael, Kerslake, William S., Kerslake, William, Ban, Maria, Owens, Matthew, Dunn, Valerie J, Dalgleish, Tim, Calder, Andrew, Goodyer, Ian M, Hiscox, Lucy, St Clair, Michelle, Goodyer, Ian, Hiscox, Lucy V, Walsh, Nicholas, Abbott, Rosemary, Passamonti, Luca, Dunn, Valerie J., Calder, Andrew J., Walsh, Nicholas D., St Clair, Michelle C., Dunn, Valerie, Fairchild, Graeme, St Clair, Michelle C; id_orcid   +27 more
core   +4 more sources

Serotonin transporter polymorphism modulates N-back task performance and fMRI BOLD signal intensity in healthy women.

PLoS ONE, 2012
ContextExploring intermediate phenotypes within the human brain's functional and structural circuitry is a promising approach to explain the relative contributions of genetics, complex behaviors and neural mechanisms in the development of major ...
Rune Jonassen, Tor Endestad, Alexander Neumeister, Kari Bente Foss Haug, Jens Petter Berg, Nils Inge Landrø   +5 more
doaj   +1 more source

Psychopathic Traits Associate With Later Schizophrenia

Acta Psychiatrica Scandinavica, Volume 152, Issue 6, Page 432-440, December 2025.
ABSTRACT Introduction Despite well‐known diagnostic and neurobiological overlaps between psychopathic traits and schizophrenia, it has remained unclear whether psychopathic traits increase the risk for later schizophrenia. Former studies have proven only a weak correlation between psychopathy and DSM axis I diagnoses.
Olli Vaurio, Jari Tiihonen, Markku Lähteenvuo, Johannes Lieslehto   +3 more
wiley   +1 more source