Results 1 to 10 of about 267,093 (291)

Serotonin transporter dependent modulation of food-seeking behavior.

PLoS ONE, 2020
The olfactory pathway integrates the odor information required to generate correct behavioral responses. To address how changes of serotonin signaling in two contralaterally projecting, serotonin-immunoreactive deutocerebral neurons impacts key odorant ...
Jianzheng He, Franziska Hommen, Nina Lauer, Sophia Balmert, Henrike Scholz   +4 more
doaj   +2 more sources

Serotonin transporter deficiency, but not absence of platelet serotonin, impairs thrombus formation in a model of deep vein thrombosis [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: The majority of peripheral serotonin is stored in dense granules of circulating blood platelets and released upon platelet activation. Recently, an immunomodulatory role of serotonin in inflammation has been found, influencing the recruitment
Katharina Naber, Maximilian Mauler, Nancy Schanze, Pia Kröning, Daniela Stallmann, Daniel Duerschmied, Dirk Westermann, Nadine Gauchel   +7 more
doaj   +2 more sources

Uterotropic response to the antidepressant fluoxetine (Prozac) is dependent on a functional serotonin transporter and circulating serotonin [PDF]

Scientific Reports
Selective serotonin reuptake inhibitors (SSRI) are the most used antidepressants. However, they appear to pose a role as endocrine disrupting agents, particularly related to estrogen signaling.
Rafael R. Domingues, Jessica Fox, Emma Day, Milo C. Wiltbank, Laura L. Hernandez   +4 more
doaj   +2 more sources

Pregnancy Complications and Neonatal Mortality in a Serotonin Transporter Null Mouse Model: Insight Into the Use of Selective Serotonin Reuptake Inhibitor During Pregnancy

Frontiers in Medicine, 2022
Selective serotonin reuptake inhibitors (SSRI) are widely prescribed to pregnant woman. Although some SSRI compounds are known to cause pregnancy loss and fetal malformations, other SSRI continue to be used by pregnant women.
Rafael R. Domingues, Rafael R. Domingues, Milo C. Wiltbank, Milo C. Wiltbank, Laura L. Hernandez, Laura L. Hernandez   +5 more
doaj   +1 more source

Targeting SERT promotes tryptophan metabolism: mechanisms and implications in colon cancer treatment

Journal of Experimental & Clinical Cancer Research, 2021
Background Serotonin signaling has been associated with tumorigenesis and tumor progression. Targeting the serotonin transporter to block serotonin cellular uptake confers antineoplastic effects in various tumors, including colon cancer.
Di Ye, Huanji Xu, Hongwei Xia, Chenliang Zhang, Qiulin Tang, Feng Bi   +5 more
doaj   +1 more source

Localization of the Serotonin Transporter in the Dog Intestine and Comparison to the Rat and Human Intestines

Frontiers in Veterinary Science, 2022
Serotonin is crucial in gastrointestinal functions, including motility, sensitivity, secretion, and the inflammatory response. The serotonin transporter (SERT), responsible for serotonin reuptake and signaling termination, plays a prominent role in ...
Roberto Chiocchetti, Giorgia Galiazzo, Fiorella Giancola, Claudio Tagliavia, Chiara Bernardini, Monica Forni, Marco Pietra   +6 more
doaj   +1 more source

A Single Pair of Serotonergic Neurons Counteracts Serotonergic Inhibition of Ethanol Attraction in Drosophila. [PDF]

PLoS ONE, 2016
Attraction to ethanol is common in both flies and humans, but the neuromodulatory mechanisms underlying this innate attraction are not well understood. Here, we dissect the function of the key regulator of serotonin signaling-the serotonin transporter-in
Li Xu, Jianzheng He, Andrea Kaiser, Nikolas Gräber, Laura Schläger, Yvonne Ritze, Henrike Scholz   +6 more
doaj   +1 more source

Relative contributions of norepinephrine and serotonin transporters to antinociceptive synergy between monoamine reuptake inhibitors and morphine in the rat formalin model. [PDF]

PLoS ONE, 2013
Multimodal analgesia is designed to optimize pain relief by coadministering drugs with distinct mechanisms of action or by combining multiple pharmacologies within a single molecule. In clinical settings, combinations of monoamine reuptake inhibitors and
Fei Shen, Pamela R Tsuruda, Jacqueline A M Smith, Glenmar P Obedencio, William J Martin   +4 more
doaj   +1 more source

Regional serotonin terminal density in aging human brain: A [11C]DASB PET study

Aging Brain, 2023
There are conflicting results regarding regional age-related changes in serotonin terminal density in human brain. Some imaging studies suggest age-related declines in serotoninergic terminals and perikarya.
Prabesh Kanel, Robert A. Koeppe, Vikas Kotagal, Stiven Roytman, Martijn L.T.M. Muller, Nicolaas I. Bohnen, Roger L. Albin   +6 more
doaj   +1 more source

Faster Serotonin Clearance in CA3 Region of Hippocampus and Antidepressant-like Effect of Decynium-22 in Juvenile Mice Are Putatively Linked to Increased Plasma Membrane Monoamine Transporter Function: Implications for Efficacy of Antidepressants in Juveniles

Cells, 2022
Selective serotonin reuptake inhibitors (SSRIs) are less efficacious in treating depression in children than in adults. SSRIs block serotonin uptake via the high-affinity, low-capacity serotonin transporter.
Melodi A. Bowman, Jorge A. Gomez, Nathan C. Mitchell, Anne M. Wells, Melissa Vitela, Kyra M. Clarke, Rebecca E. Horton, Wouter Koek, Lynette C. Daws   +8 more
doaj   +1 more source