Serotonin Transporter Inhibits Antitumor Immunity Through Regulating the Intratumoral Serotonin Axis [PDF]
CellLili Yang, Yichen Zhu
exaly +2 more sources
5-hydroxytryptamine (5-HT) cellular sequestration during chronic exposure delays 5-HT3 receptor resensitization due to Its subsequent release [PDF]
, 2014 The serotonergic synapse is dynamically regulated by serotonin (5-hydroxytryptamine (5-HT)) with elevated levels leading to the down-regulation of the serotonin transporter and a variety of 5-HT receptors, including the 5-HT type-3 (5-HT3) receptors.
Moffat, Christopher +5 more
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Involvement of serotonin transporter extracellular loop 1 in serotonin binding and transport [PDF]
Molecular Membrane Biology, 2008 Residues Tyr-110 through Gly-115 of serotonin transporter were replaced, one at a time, with cysteine. Of these mutants, only G113C retained full activity for transport, Q111C and N112C retained partial activity, but Y110C, G114C and G115C were inactive.
Yuxin Mao +13 more
openaire +2 more sources
Molecular imaging of serotonin degeneration in mild cognitive impairment
Neurobiology of Disease, 2017 Neuropathological and neuroimaging studies have consistently demonstrated degeneration of monoamine systems, especially the serotonin system, in normal aging and Alzheimer's disease. The evidence for degeneration of the serotonin system in mild cognitive
Gwenn S. Smith +12 more
doaj +1 more source
Serotonin transport in the 21st century [PDF]
Journal of General Physiology, 2019 Serotonin (5-hydroxytryptamine [5-HT]) is accumulated within nerve endings by the serotonin transporter (SERT), which terminates its extracellular action and provides cytoplasmic 5-HT for refilling of synaptic vesicles. SERT is the target for many antidepressant medications as well as psychostimulants such as cocaine and ecstasy (3,4 ...
Gary Rudnick, Walter Sandtner
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Mapping functional brain activation using [14C]-iodoantipyrine in male serotonin transporter knockout mice. [PDF]
PLoS ONE, 2011 BACKGROUND: Serotonin transporter knockout mice have been a powerful tool in understanding the role played by the serotonin transporter in modulating physiological function and behavior.
Raina D Pang +7 more
doaj +1 more source
Molecular fMRI of Serotonin Transport [PDF]
Neuron, 2016 Reuptake of neurotransmitters from the brain interstitium shapes chemical signaling processes and is disrupted in several pathologies. Serotonin reuptake in particular is important for mood regulation and is inhibited by first-line drugs for treatment of depression.
Hai, Aviad +4 more
openaire +4 more sources
Serotonin receptor mechanisms in anti-depressant action [PDF]
, 2003 Bibliography: leaves 221-270.Serotonin neurones have been implicated in the pathophysiology and treatment of clinical depression to a greater degree than any other neurotransmitter.
Quested, Digby John
core +1 more source
Predicting Serotonin Transporter Haplotypes Based on Reinforcement Learning
, 2022 Background: Serotonergic neurotransmission has been implicated in risk assessment, processing of negative feedback, and encoding value and time interaction.
Ru'a Rimawi +2 more
core +1 more source
Serotonin transporter in the temporal lobe, hippocampus and amygdala in SUDEP [PDF]
, 2022 Several lines of evidence link deficient serotonin function and SUDEP. Chronic treatment with serotonin reuptake inhibitors (SRIs) reduces ictal central apnoea, a risk factor for SUDEP.
Liu, J.Y.W. +33 more
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