Results 31 to 40 of about 267,093 (291)

Serotonin transporters in ecstasy users [PDF]

British Journal of Psychiatry, 2000
Semple et al ([1999][1]) report a reduction in vivo of 123I-labelled 2β-carbomethoxy-3β-(4-iodophenyl)tropane (β-CIT) uptake in the cerebral cortex of 3,4-methylenedioxymethamphetamine (MDMA, ‘ ecstasy’) users.
A, Heinz, D W, Jones
openaire   +2 more sources

Dopamine-Serotonin Transporter Disease

Pediatric Neurology Briefs, 2013
Investigators at the Hospital for Sick Children, University of Toronto, Canada report 8 children of a consanguineous Saudi Arabian family who had a similar movement disorder, with autosomal recessive inheritance and a mutation in the SLC18A2 gene that ...
J Gordon Millichap
doaj   +1 more source

Effect of Selected Antidepressants on Placental Homeostasis of Serotonin: Maternal and Fetal Perspectives

Pharmaceutics, 2021
Depression is a prevalent condition affecting up to 20% of pregnant women. Hence, more than 10% are prescribed antidepressant drugs, mainly serotonin reuptake inhibitors (SSRIs) and selective serotonin and noradrenaline reuptake inhibitors (SNRIs).
Hana Horackova, Rona Karahoda, Lukas Cerveny, Veronika Vachalova, Ronja Ebner, Cilia Abad, Frantisek Staud   +6 more
doaj   +1 more source

Pharmacology of novel psychoactive substances [PDF]

, 2016
This PhD work consists of an in vitro and in vivo part. In the in vivo part, we investigated the role of dopamine in the acute clinical effects of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) in healthy human subjects.
Rickli, Anna
core   +1 more source

Chronic tension-type facial pain- a pilot study on HTTLPR genetic polymorphisms [PDF]

Rhinology Online, 2019
Background: This study looked at the association between serotonin transporter gene variants and with chronic persistent tension-type facial pain. Known as triallelic 5-HTTLPR, the serotonin transporter gene-linked polymorphic region and its rs25531 ...
A.M. Agius, R. Muscat
doaj   +1 more source

Repeated methamphetamine treatment increases spine density in the nucleus accumbens of serotonin transporter knockout mice

Neuropsychopharmacology Reports, 2019
Aim Repeated psychostimulant drug treatment, including methamphetamine, in rodents readily produces behavioral sensitization, which reflects altered brain function caused by repeated drug exposure.
Yoshiyuki Kasahara, Yasufumi Sakakibara, Takashi Hiratsuka, Yuki Moriya, Klaus‐Peter Lesch, F. Scott Hall, George R. Uhl, Ichiro Sora   +7 more
doaj   +1 more source

Genetic and pharmacological manipulations of the serotonergic system in early life: Neurodevelopmental underpinnings of autism-related behaviour

Frontiers in Cellular Neuroscience, 2013
Serotonin, in its function as neurotransmitter, is well-known for its role in depression, autism and other neuropsychiatric disorders, however less known as a neurodevelopmental factor.
Karsten eKinast, Deborah ePeeters, Sharon Margriet Kolk, Dirk eSchubert, Judith Regina Homberg   +4 more
doaj   +1 more source

Effects of Serotonin Transporter Promoter Polymorphisms on Serotonin Function [PDF]

Neuropsychopharmacology, 2004
The serotonin transporter promoter polymorphism (5-HTTLPR) has been associated with vulnerability to stress-induced depressive symptoms and with the speed and rate of response to antidepressant treatment. The goal of the present study was to evaluate the association between the 5-HTTLPR and the functional response of the serotonin system as measured by
Gwenn S, Smith, Francis E, Lotrich, Anil K, Malhotra, Annette T, Lee, Yilong, Ma, Elisse, Kramer, Peter K, Gregersen, David, Eidelberg, Bruce G, Pollock   +8 more
openaire   +2 more sources

Flunarizine as a potential repurposed drug for the serotonin transporter inhibition: an integrated approach for therapeutic development against major depressive disorder

Frontiers in Pharmacology
Major depressive disorder (MDD) is a serious neuropsychiatric condition that affects millions of people worldwide, causing significant psychological distress and lifestyle deterioration.
Abdelbaset Mohamed Elasbali, Abdelbaset Mohamed Elasbali, Ahmed S. Ali, Ahmed S. Ali, Taj Mohammad, Mohd Adnan, Mohd Adnan, Anas Shamsi, Md. Imtaiyaz Hassan   +8 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source