Results 11 to 20 of about 267,093 (291)
PLoS ONE, 2013 The competitive inhibitor cocaine and the non-competitive inhibitor ibogaine induce different conformational states of the human serotonin transporter.
Heidi Koldsø +3 more
doaj +2 more sources
Developmental roles for the serotonin transporter
, 2010 From invertebrates to humans, serotonin (5-HT) exerts structural effects especially during development. The 5-HT transporter (SERT) directly regulates these effects by maintaining extracellular 5-HT concentrations within a physiological range and possibly by modulating the intracellular redox state of the cell.
Persico A. M., Antonio M. Persico
openaire +3 more sources
Serotonin reuptake inhibitors and cardiovascular disease [PDF]
, 2005 Selective serotonin re-uptake inhibiting drugs (SSRIs) are widely used for endogenous depression. In addition to depleting the nerve terminals of serotonin they also lower blood platelet serotonin levels.
Noble, M. +2 more
core +8 more sources
The Serotonin Transporter Gene and Parkinson’s Disease
European Neurology, 2000 Dysfunction in the serotonin (5-hydroxytryptamine) system and reduced serotonin concentrations have been reported in patients with Parkinson’s disease (PD). Serotonin concentrations in neural tissue are controlled by a presynaptic serotonin transporter protein that is encoded by a single gene.
McCann, Sally J. +5 more
openaire +6 more sources
Partitioning of the Serotonin Transporter into Lipid Microdomains Modulates Transport of Serotonin [PDF]
Journal of Biological Chemistry, 2004 The serotonin transporter (SERT) is an integral membrane protein responsible for the clearance of serotonin from the synaptic cleft following the release of the neurotransmitter. SERT plays a prominent role in the regulation of serotoninergic neurotransmission and is a molecular target for multiple antidepressants as well as substances of abuse.
MAGNANI, FRANCESCA +4 more
openaire +3 more sources
Serotonin and serotonin transporter levels in autistic children [PDF]
Saudi Medical Journal, 2018 To assess the possible correlation between serotonin and serotonin transporter (SERT) with the autism severity and investigate the association between these parameters in autistic children to assess their possible role for diagnosis of autism severity.A comparative cross-sectional study was carried out in the Chemistry and Biochemistry Department ...
Abdulamir, Haidar A. +2 more
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Plasma serotonin levels and the platelet serotonin transporter [PDF]
Journal of Neurochemistry, 2007 AbstractSerotonin (5HT) is a platelet‐stored vasoconstrictor. Altered concentrations of circulating 5HT are implicated in several pathologic conditions, including hypertension. The actions of 5HT are mediated by different types of receptors and terminated by a single 5HT transporter (SERT). Therefore, SERT is a major mechanism that regulates plasma 5HT
B, Brenner +6 more
openaire +2 more sources
The Serotonin Transporter [PDF]
Circulation Research, 2004 Primary pulmonary hypertension (PPH) is a life-threatening disease that mostly affects young adults, more commonly women than men. It is characterized by vasoconstriction of the small pulmonary arteries, proliferation in all layers of the vessel wall, thrombosis-in situ, and inflammation.
E. Kenneth Weir +2 more
openaire +1 more source
PLoS ONE, 2015 Serotonin plays an important role in the etiology of depression. Serotonin is also crucial for brain development. For instance, animal studies have demonstrated that early disruptions in the serotonin system affect brain development and emotion ...
Linda Booij +11 more
doaj +1 more source
Annals of Indian Psychiatry, 2021 Serotonin transporter-linked polymorphic regions (5-HTTLPR) have been investigated intensively in suicide with inconsistent findings. However, a recent meta-analysis has observed an association of S allele with violent attempted suicide.
Bisu Singh
doaj +1 more source