Results 61 to 70 of about 79,000,091 (170)

Shared Genetic Architecture Among Severe Mental Disorders: A System Biology Approach Based on Protein–Protein Interaction

Brain and Behavior, Volume 15, Issue 9, September 2025.
This study explores the genetic overlap among PTSD, MDD, BD, and SZ, revealing shared biological pathways and co‐expression networks. Functional enrichment analysis highlights common molecular mechanisms underlying these psychiatric disorders, providing insights into their comorbidity and potential avenues for targeted therapeutic strategies.
Hernan F. Guillen‐Burgos, Valentina Vanegas, Isabella Gonzalez, Ana M. Caicedo, Valentina Arango, Juan F. Galvez‐Florez, Juan‐Manuel Anaya, Roger S. McIntyre, Wilson Terán   +8 more
wiley   +1 more source

Rates of current PTSD diagnosis by 5-HTTLPR genotype.

, 2015
Rates of current PTSD diagnosis by 5-HTTLPR genotype.
Michael A. Hauser (51606), Kimberly T. Green (707779), Michelle F. Dennis (707778), Nathan A. Kimbrel (707781), Yutao Liu (87989), Jean C. Beckham (707780), Melanie E. Garrett (167734), Allison E. Ashley-Koch (119700)   +7 more
core   +1 more source

Genetic Inactivation of the Serotonin Transporter Dysregulates Expression of Neurotransmission Genes and Genome‐Wide DNA Methylation Levels in the Medial Prefrontal Cortex of Male Rats During Postnatal Development

Developmental Neurobiology, Volume 85, Issue 3, July 2025.
ABSTRACT Reduced expression of the serotonin transporter (5‐hydroxytryptamine transporter, 5‐HTT) in early life has been associated with a delay in postnatal brain development and endophenotypes of a variety of neuropsychiatric and neurodevelopmental disorders in adolescence and adulthood.
Yvet Kroeze, Martin Oti, Roel H. M. Cooijmans, Ellen van Beusekom, Leonie I. Kroeze, Anthonieke Middelman, Hans van Bokhoven, Sharon M. Kolk, Judith R. Homberg, Huiqing Zhou   +9 more
wiley   +1 more source

5-HTTLPR variant distribution between male and female individuals.

, 2014
5-HTTLPR variant distribution between male and female individuals.
Feng Kong (459884), Qing Zhang (1802), Fenglan Lou (548101), Dawei Xu (83739), Chengyun Zheng (548103), Jiajia Liu (345509), Tiantian Liu (548100), Magnus Björkholm (83738), Ping Li (31981), Guanghui Cheng (548102)   +9 more
core   +1 more source

Meta-analysis of the interaction between serotonin transporter promoter variant, stress, and posttraumatic stress disorder

Scientific Reports, 2017
Exposure to stress predicts the occurrence of posttraumatic stress disorder (PTSD) in individuals harboring the serotonin transporter promoter variant 5-HTTLPR.
Mingzhe Zhao, Jiarun Yang, Wenbo Wang, Jingsong Ma, Jian Zhang, Xueyan Zhao, Xiaohui Qiu, Xiuxian Yang, Zhengxue Qiao, Xuejia Song, Lin Wang, Shixiang Jiang, Erying Zhao, Yanjie Yang   +13 more
doaj   +1 more source

The influence of psychiatric screening in healthy populations selection: a new study and meta-analysis of functional 5-HTTLPR and rs25531 polymorphisms and anxiety-related personality traits

BMC Psychiatry, 2011
Background A genetic liability for anxiety-related personality traits in healthy subjects has been associated with the functional serotonin transporter promoter polymorphism (5-HTTLPR), although the data are somewhat conflicting. Moreover, only one study
Sartori Riccardo, Scassellati Catia, Bonvicini Cristian, Minelli Alessandra, Gennarelli Massimo   +4 more
doaj   +1 more source

The Interplay of Chronic Stress and Cancer: Pathophysiology and Implications for Integrated Care

Cancer Reports, Volume 8, Issue 5, May 2025.
ABSTRACT Background Cancer‐associated depression is a multifaceted condition that arises from the interplay of biological, psychological, and social factors in individuals diagnosed with cancer. Understanding this condition involves exploring how cancer and its treatments can precipitate depressive symptoms and the mechanisms behind this association ...
Joyeeta Talukdar, Megha, Hemant Choudhary, Sushma Bhatnagar, Anuja Pandit, Ashwani Kumar Mishra, Subhradip Karmakar, Pratap Sharan   +7 more
wiley   +1 more source

Association of the 5-HTT gene-linked promoter region (5-HTTLPR) polymorphism with psychiatric disorders: review of psychopathology and pharmacotherapy

, 2012
George A Kenna1, Nick Roder-Hanna2, Lorenzo Leggio3, William H Zywiak4, James Clifford5, Steven Edwards3, John A Kenna6, Jessica Shoaff1, Robert M Swift11Center for Alcohol and Addiction Studies, Department of Psychiatry and Human Behavior, Brown ...
Zywiak WH, Edwards S, Leggio L, Clifford J, Roder-Hanna N, Shoaff J, Kenna JA, Kenna GA, Swift RM   +8 more
core  

COMT Val 158 Met x SLC6A4 5-HTTLPR interaction impacts on gray matter volume of regions supporting emotion processing

, 2014
International audienceThere have been several reports on the association between the Val 158 Met genetic polymorphism of the catechol-O-methyltransferase (COMT) gene, as well as the serotonin transporter-linked polymorphic region (5-HTTLPR) of the ...
Surguladze, S. A., Monté, Gemma C., Radua, J., Surguladze, Simon A., Gohier, B., Tropeano, M., Gohier, Bénédicte, Radua, Joaquim, Phillips, Mary, El-Hage, W., Surguladze, Simon, Monte, G. C., El-Hage, Wissam, Phillips, Mary L., Tropeano, Maria, Phillips, M. L., Monté, Gemma, C   +16 more
core   +1 more source

O Polimorfismo 5-HTTLPR e o transtorno de déficit de atenção e hiperatividade (TDAH) em adultos [PDF]

, 2008
Vários transtornos psiquiátricos têm sido associados ao gene do transportador da serotonina. Sua região promotora contém um polimorfismo (5-HTTLPR) de número variável de seqüências, permitindo distinguir um alelo longo de um curto.
Kortmann, Gustavo Lucena
core   +1 more source