Results 71 to 80 of about 79,000,091 (170)

Serotonergic underpinnings of obsessive‐compulsive disorder: A systematic review and meta‐analysis of neuroimaging findings

Psychiatry and Clinical Neurosciences, Volume 79, Issue 2, Page 48-59, February 2025.
Obsessive‐compulsive disorder (OCD) is a frequent and disabling condition, with many patients being treatment‐resistant. Improved understanding of its neurobiology is vital for better therapies. Evidence is still conflicting regarding specific serotonergic‐related dysfunctions in OCD.
Martin Pastre, Bob‐Valéry Occéan, Vincent Boudousq, Ismael Conejero, Pascale Fabbro‐Peray, Laurent Collombier, Luc Mallet, Jorge Lopez‐Castroman   +7 more
wiley   +1 more source

The Recent Progress in the Research on Association Between 5-HTTLPR and Depression

, 2012
本文对5-HTTLPR与抑郁关系的相关研究进行了综述。5-HTTLPR基因型并不直接影响抑郁的发生,而是通过基因与环境交互作用影响的。携带有S等位基因的个体暴露于较多的负性生活事件时,更易发生抑郁。另外,5-HTTLPR还与CYP2C9、BDNF等基因存在交互作用。研究发现5-HTTLPR对抑郁作用的机制可能有两条。首先,和基因型为L/L的个体相比,携带有S等位基因的个体的杏仁核脑区的活动增强,而前额叶-杏仁核神经环路的耦合相对较弱。其次,携带有S等位基因的个体在应激条件下HPA轴活性更强 ...
张俊先, 陈杰, 李新影
core  

Serotonin transporter gene polymorphic element 5-HTTLPR increases the risk of sporadic Parkinson's disease in Italy

, 2009
Parkinson's disease (PD) is a neurodegenerative disorder causing muscular rigidity, resting tremor and bradykinesia. We conducted an association study assessing how PD risk in Italy was influenced by the serotonin transporter gene (SLC6A4) polymorphic ...
S. Batelli, C. Lovati, E. Scarpini, A. Vittori, L. Polito, S. De Mauro, G. Forloni, D. Galimberti, C. Mariani, D. Albani, Letizia Polito, Claudio Mariani, Daniela Galimberti, Diego Albani, Elio Scarpini, Carlo Lovati, Angelica Vittori, Sara Batelli, Stefania De Mauro, Gianluigi Forloni   +19 more
core   +1 more source

The association between childhood maltreatment and empathic perspective taking is moderated by the 5-HTT linked polymorphic region: Another example of "differential susceptibility".

PLoS ONE, 2019
Previous research has suggested that the short (S)-allele of the 5-HT transporter gene-linked polymorphic region (5-HTTLPR) may confer "differential susceptibility" to environmental impact with regard to the expression of personality traits, depressivity
Vera Flasbeck, Dirk Moser, Johanna Pakusch, Robert Kumsta, Martin Brüne   +4 more
doaj   +1 more source

Polygene by environment interactions predicting depressive outcomes

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 198, Issue 1, January 2025.
Abstract Depression is a major public health problem with a continued need to uncover its etiology. Current models of depression contend that gene‐by‐environment (G × E) interactions influence depression risk, and further, that depression is polygenic. Thus, recent models have emphasized two polygenic approaches: a hypothesis‐driven multilocus genetic ...
Alessandra R. Grillo
wiley   +1 more source

5-HTTLPR genotype, neuroticism, and financial choices.

, 2013
The presence of the short allele of the 5-HTTLPR gene relates to the avoidance of risky and complex financial choices. These genetic effects are mediated by neuroticism.
Gregory R. Samanez-Larkin (206714), Brian Knutson (177053), Camelia M. Kuhnen (206717)   +2 more
core   +1 more source

Association between polymorphisms in the serotonin transporter gene-linked polymorphic region and risk for irritable bowel syndrome in China: evidence based on a meta-analysis

Journal of International Medical Research, 2019
Objective The association between mutations in the serotonin transporter gene-linked polymorphic region (5-HTTLPR) and irritable bowel syndrome (IBS) differs between populations. This meta-analysis was designed to assess the relationship between 5-HTTLPR
Zhanbo Jia, Liping Wang, Bianfang Yu, Qinggang Li, Xin Dong   +4 more
doaj   +1 more source

Comprehensive Review and Meta‐Analysis of Psychological and Pharmacological Treatment for Intermittent Explosive Disorder: Insights From Both Case Studies and Randomized Controlled Trials

Clinical Psychology &Psychotherapy, Volume 32, Issue 1, January/February 2025.
ABSTRACT Intermittent explosive disorder (IED) is characterized by sudden, disproportionate outbursts of anger that can severely impact individuals' quality of life, causing difficulties in maintaining relationships, issues at work or school and potential legal troubles.
Fangqing Liu, Xiaoshan Yin, Wenting Jiang   +2 more
wiley   +1 more source

Genetic variation in the serotonin transporter gene (5-HTTLPR, rs25531) influences the analgesic response to the short acting opioid Remifentanil in humans

Molecular Pain, 2009
Background There is evidence from animal studies that serotonin (5-HT) can influence the antinociceptive effects of opioids at the spinal cord level. Therefore, there could be an influence of genetic polymorphisms in the serotonin system on individual ...
Schalling Martin, Lonsdorf Tina B, Jensen Karin B, Kosek Eva, Ingvar Martin   +4 more
doaj   +1 more source

Association between 5-HTTLPR and neuroticism in borderline personality disorder

, 2011
Neuroticism is characterized by emotional instability and the tendency to experience negative emotions such as anger, anxiety and depressed mood. Subjects with borderline personality disorder (BPD) present this personality dimension as a temperamental ...
S. Jerez Concha, H. Silva Ibarra, P. Iturra Constant, J. Villarroel Garrido, C. Montes Aguirre, M.L. Bustamante Calderon, M. Fuentes Salgado   +6 more
core   +1 more source