Results 51 to 60 of about 79,000,091 (170)

5-HTTLPR and use of antidepressants after colorectal cancer including a meta-analysis of 5-HTTLPR and depression after cancer

, 2015
The serotonin-transporter-linked polymorphic region (5-HTTLPR) is one of the most extensively investigated candidates to be involved in gene-environment interaction associated with depression. Nevertheless, the interaction remains controversial.
Moffitt, T E, Tjønneland, A, Dalton, S O, Bukh, J D, Caspi, A, Johansen, C, Albieri, V, Suppli, N P, Kessing, L V   +8 more
core   +1 more source

Serotonin transporter genomic biomarker for quantitative assessment of ondansetron treatment response in alcoholics

Frontiers in Psychiatry, 2012
Paucity of sensitive biomarkers to quantify transient changes in alcohol consumption level remains a critical barrier for the development of efficacious therapeutic agents to treat alcoholism.
Chamindi eSeneviratne, Bankole A Johnson
doaj   +1 more source

Predicting adolescent disordered eating and behaviours: exploring environmental moderators of polygenic risk

Journal of Child Psychology and Psychiatry, Volume 66, Issue 12, Page 1795-1806, December 2025.
Background Both genetic and environmental factors contribute to the risk of developing disordered eating, with twin studies demonstrating environmental factors moderate genetic susceptibility. To date, gene–environment interactions leveraging polygenic risk scores (PRS) have not been studied in disordered eating phenotypes beyond anorexia nervosa (AN).
Madeleine Curtis, Lucia Colodro‐Conde, Sarah E. Medland, Scott Gordon, Nicholas G. Martin, Tracey D. Wade, Sarah Cohen‐Woods   +6 more
wiley   +1 more source

Association study of serotonin transporter SLC6A4 gene with Chinese Han irritable bowel syndrome. [PDF]

PLoS ONE, 2014
OBJECTIVE: Irritable bowel syndrome (IBS) is a common clinical gastrointestinal dysfunction disorders. 5-sertonon (5-hydroxytryptamine, 5-HT) is a very important neurotransmitter, which is involved in gastrointestinal motion and sensation. Solute carrier
Jing Yuan, ChuanYuan Kang, Min Wang, Qiang Wang, PeiKai Li, Hua Liu, Yu Hou, Ping Su, Fan Yang, YuJun Wei, JianZhong Yang   +10 more
doaj   +1 more source

Genetics of Response to ECT, TMS, Ketamine and Esketamine

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 198, Issue 7, Page 88-102, October 2025.
ABSTRACT Treatment‐resistant mood disorders are often managed with intensive interventions that include electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), ketamine, and esketamine, but the role of genetics in clinical response to those interventions is yet to be clearly determined.
Clio E. Franklin, Murat Altinay, Kala Bailey, Mahendra T. Bhati, Brent R. Carr, Susan K. Conroy, Khurshid Khurshid, William M. McDonald, Brian J. Mickey, James W. Murrough, Sean M. Nestor, Thomas Nickl‐Jockschat, Irving M. Reti, Gerard Sanacora, Nicholas T. Trapp, Biju Viswanath, Jesse H. Wright, Peter P. Zandi, James B. Potash   +18 more
wiley   +1 more source

Serotonin transporter 5-HTTLPR genotype is associated with intrusion and avoidance symptoms of DSM-5 posttraumatic stress disorder (PTSD) in Chinese earthquake survivors

, 2017
Background and Objectives: Prior studies have found that the serotonin transporter gene-linked polymorphic region (5-HTTLPR) interacts with trauma exposure to increase general risk for Posttraumatic Stress Disorder (PTSD).
Wang, Li, Zhu, Ye, Luobing Liu, Ye Zhu, Jianxin Zhang, Cao, Chengqi, Zhang, Jianxin, Li Wang, Liu, Luobing, Ping Liu, Shu Luo, Chengqi Cao, Liu, Ping, Xing Cao, Luo, Shu, Cao, Xing   +15 more
core   +1 more source

The Role of Genetics in Stroke Risk and Outcome: A Review of Current Evidence

Brain and Behavior, Volume 15, Issue 10, October 2025.
This study delineates the multiple pathways leading to stroke, encompassing genetic risk factors such as lipid/cholesterol metabolism, blood pressure regulation genes, and endothelial dysfunction. The report includes genetic pathways such as Val66Met polymorphism, prothrombin G20210A, interleukin‐6 and tumor necrosis factor gene variant, along with ...
Mega Obukohwo Oyovwi, Benneth Ben‐Azu, Ejayeta Jeroh, Faith B. Friday   +3 more
wiley   +1 more source

Frequencies of the genotypes and alleles of the 5-HTTLPR.

, 2016
Frequencies of the genotypes and alleles of the 5-HTTLPR.
Salvatore Iuso (2817853), Francesco Sessa (2817850), Giovanna D'Andrea (2817856), Mario Altamura (143457), Maurizio Margaglione (569251), Flavia A. Padalino (2817847), Annamaria Petito (358698), Antonello Bellomo (2817859)   +7 more
core   +1 more source

The 5-HTTLPR genotype, early life adversity and cortisol responsivity to psychosocial stress in women

BJPsych Open, 2018
BackgroundThe serotonin transporter gene-linked polymorphic region (5-HTTLPR) has previously been associated with hypothalamus–pituitary–adrenal axis function.
Jurate Aleknaviciute, Joke H. M. Tulen, Yolanda B. de Rijke, Mark van der Kroeg, Cornelis G. Kooiman, Steven A. Kushner   +5 more
doaj   +1 more source

Genetic Basis of the Negative Response to the Use of Triptans for the Treatment of Migraine—A Systematic Review and Meta‐Analysis

Brain and Behavior, Volume 15, Issue 10, October 2025.
To systematize the genetic basis correctly associated with nonresponse to triptan, we revised etiological studies on Web of Science, Embase, and PubMed until 2023. We found that only polymorphisms in the SLC6A4, 5‐HT1B, and COMT genes have a stronger association with this condition. More robust studies are needed to increase this certainty.
Victoria Gomes Andreata, Ruan Pablo Duarte Freitas, Jéssica da Silva Nascimento, Patrícia Sodré Araújo, Felipe Eustáquio dos Santos Guedes, João Vítor Benjamim Pires, Narel Moita Carneiro Nogueira Falcão, Natasha da Silva Leitão, Alcylene Carla de Jesus dos Santos, Ana Patrícia Pascoal Queiroz, Astria Ferrão Dias Gonzales, Maica Matos Leão, Emília Katiane Embiruçu de Araújo Leão, Juliana Côrtes Freitas, Acássia Benjamim Leal Pires   +14 more
wiley   +1 more source