5-Hydroxyindoleacetic acid, a new ligand for GPR35, plays an important role in inflammatory disease [PDF]
Yang Zhisheng +3 more
doaj +2 more sources
Inhibition of 5-hydroxyindoleacetic acid to reduce neutrophil extracellular trap production improves lung condition in chronic obstructive pulmonary disease mice [PDF]
Background Neutrophil extracellular trap (NET) correlate with chronic obstructive pulmonary disease (COPD) severity. Platelets can promote NET generation. However, serotonin alone or serotonin-deficient platelets do not adequately promote NET production.
Qiang Zeng +6 more
doaj +2 more sources
Amelioration of tic disorder by Jujuboside A via gut microbiota remodeling and intestinal 5-HT signaling [PDF]
BackgroundTic disorder (TD) is a common chronic neuropsychiatric condition manifesting during childhood and adolescence. Jujuboside A (JuA) may alleviate TD symptoms; however, the mechanisms underlying its therapeutic effects remain unclear.MethodsWe ...
Fei Fan +4 more
doaj +2 more sources
Contrast-Enhanced Ultrasound and Somatostatin Receptor Scintigraphy Unveil an Occult Neuroendocrine Tumor With Carcinoid Syndrome and Presumed Small Intestinal Origin – A Case Report [PDF]
A 68-year-old man with postprandial flushing and palpitations was referred for multiple hepatic lesions. Computed tomography showed hypoattenuating metastases without a detectable primary, whereas contrast-enhanced ultrasound revealed arterial ...
Tairyu Sato +21 more
doaj +2 more sources
Effect of Lanreotide Depot/Autogel on Urinary 5-Hydroxyindoleacetic Acid and Plasma Chromogranin A Biomarkers in Nonfunctional Metastatic Enteropancreatic Neuroendocrine Tumors [PDF]
Nilani Liyanage +2 more
exaly +2 more sources
Prevalence, one-year-incidence and predictors of carcinoid heart disease
Background Carcinoid heart disease (CHD) caused by neuroendocrine tumours (NET) is associated with an increased morbidity and mortality due to valvular dysfunction and right sided heart failure.
Isabel Mattig +6 more
doaj +1 more source
Glioma induced alterations in fecal short-chain fatty acids and neurotransmitters
Aim: To explore fecal short-chain fatty acids and neurotransmitter alterations in a mouse–glioma model and glioma patients. Methods: Liquid chromatography–mass spectrometry and 16S rRNA-sequencing from fecal samples were performed to measure metabolite ...
Antonio Dono +8 more
doaj +1 more source
Mechanism of Opsoclonus-Myoclonus Syndrome
Cerebrospinal fluid measurements of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) and the dopamine metabolite homovanillic acid (HVA) in samples from 27 children with opsoclonus-myoclonus syndrome and 47 controls are reported from the ...
J Gordon Millichap
doaj +1 more source
Five boys with Lesch-Nyhan syndrome and varying degrees of dystonia, chorea, spasticity, ataxia, dysarthria, and mental retardation were studied at the Depts of Neurology and Medicine, Baylor College of Medicine, and Depts of Neurology and Pediatrics ...
J Gordon Millichap
doaj +1 more source
Psychopathology and 5-hydroxyindoleacetic acid excretion [PDF]
Abstract Schizophrenics and nonschizophrenics do not differ in urinary excretion of 5-hydroxyindoleacetic acid on either a concentration or 24 h basis, nor do they differ in variability of excretion. Although a pattern was observed of decreasing psychopathology with increasing 5-hydroxyindoleacetic acid excretion, this pattern may be related to ...
openaire +3 more sources

