Biomarker of urinary 5-HIAA as a valuable predictor of acute appendicitis [PDF]
Practical Laboratory Medicine, 2021 Background: Serotonin-containing cells are abundantly found in the appendix. Studies have shown that acute appendicitis is likely to be characterized by altered urinary 5-hydroxyindole acetic acid (5-HIAA), an active serotonin metabolite. The aim of this
Mojtaba Ahmadinejad +2 more
exaly +4 more sources
The Role of Serum 5-HIAA as a Predictor of Progression and an Alternative to 24-h Urine 5-HIAA in Well-Differentiated Neuroendocrine Neoplasms [PDF]
Biology, 2021 Our aim was to investigate the clinical utility of serum 5HIAA for disease surveillance and diagnostic purposes in a cohort of patients with well-differentiated neuroendocrine neoplasms (WD-NENs).
Maria Wedin +4 more
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Measurement of urinary 5-HIAA: correlation between spot versus 24-h urine collection [PDF]
Endocrine Connections, 2019 Background: The 24-h urinary output of 5-hydroxyindoleacetic acid (5-HIAA) is used to monitor disease progression and treatment responses of neuroendocrine neoplasms (NENs).
Matilde Calanchini +5 more
doaj +2 more sources
Enhancing immunotherapy efficacy in NSCLC through the combined use of phenelzine and Akkermansia muciniphila to regulate gut microbial metabolite 5-HIAA [PDF]
Journal for ImmunoTherapy of CancerBackground Improving the efficacy of anti-programmed death 1 (PD-1) monoclonal antibody (mAb) therapy remains a major challenge for cancer immunotherapy in non-small cell lung cancer (NSCLC). Gut microbial metabolites can influence immunotherapy efficacy.
Jie Zhao +18 more
doaj +2 more sources
Gender-Specific Effect of 5-HT and 5-HIAA on Threshold Level of Behavioral Symptoms and Sex-Bias in Prevalence of Autism Spectrum Disorder [PDF]
Frontiers in Neuroscience, 2020 Platelet hyperserotonemia in a subset of Autism Spectrum Disorder (ASD) probands, efficacy of selective serotonin reuptake inhibitors (SSRIs) in reducing behavioral deficits and gender-bias in normal serotonin (5-hydroxy tryptamine or 5-HT) synthesis ...
Barnali Chakraborti +13 more
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5-HIAA induces neprilysin to ameliorate pathophysiology and symptoms in a mouse model for Alzheimer’s disease [PDF]
Acta Neuropathologica Communications, 2018 Serotoninergic activation which decreases brain Aβ peptides is considered beneficial in mouse models for Alzheimer’s disease (AD), but the mechanisms involved remain unclear.
Christian Klein +6 more
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The diagnostic utility of urinary 5-HIAA and leucine-rich alpha-2 glycoprotein in acute appendicitis: a narrative review [PDF]
Frontiers in MedicineBackgroundAcute appendicitis (AA) remains diagnostically challenging despite its global prevalence. Current methods rely on clinical scoring systems (e.g., Alvarado score) and imaging (US, CT, and MRI). Urinary biomarkers like 5-hydroxyindoleacetic acid (
Yahiya Baig +2 more
doaj +2 more sources
GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA [PDF]
Cell, 2022 Hanson Tam +2 more
exaly +3 more sources
Neuroinflammatory-related biomarkers and psychiatric symptom changes in substance use disorder: a South African cohort study [PDF]
BMC PsychiatryBackground Substance use disorder (SUD) is a debilitating neuropsychiatric condition characterized by persistent compulsive drug use and associated cognitive and psychiatric impairments.
Alexio Dos Santos +2 more
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Development and validation of dispersive liquid-liquid microextraction coupled with LC-MS/MS for plasma 5-hydroxyindoleacetic acid quantification with application as a biomarker in major depressive disorder [PDF]
Scientific ReportsA sensitive dispersive liquid-liquid microextraction (DLLME) coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for plasma 5-hydroxyindoleacetic acid (5-HIAA) quantification as a depression biomarker.
Saleh I. Alaqel +6 more
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