Platelets and mast cells promote pathogenic eosinophil recruitment during invasive fungal infection via the 5-HIAA-GPR35 ligand-receptor system [PDF]
Immunity, 2023 Cryptococcus neoformans is the leading cause of fungal meningitis and is characterized by pathogenic eosinophil accumulation in the context of type-2 inflammation.
Hiten D. Madhani +2 more
exaly +6 more sources
Systemic Regulation of RAS/MAPK Signaling by the Serotonin Metabolite 5-HIAA. [PDF]
PLoS Genetics, 2015 Human cancer is caused by the interplay of mutations in oncogenes and tumor suppressor genes and inherited variations in cancer susceptibility genes. While many of the tumor initiating mutations are well characterized, the effect of genetic background ...
Tobias Schmid +5 more
doaj +5 more sources
5-hydroxyindolacetic acid (5-HIAA), a main metabolite of serotonin, is responsible for complete Freund's adjuvant-induced thermal hyperalgesia in mice [PDF]
Molecular Pain, 2011 Background The role of serotonin (5-hydroxytrptamine, 5-HT) in the modulation of pain has been widely studied. Previous work led to the hypothesis that 5-hydroxyindolacetic acid (5-HIAA), a main metabolite of serotonin, might by itself influence pain ...
Moessner Rainald +5 more
doaj +4 more sources
Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease [PDF]
Advanced ScienceAccumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction.
Shuping Qiao +11 more
doaj +2 more sources
Cerebrospinal fluid levels of 5-HIAA and dopamine in people with HIV and depression. [PDF]
J Neurovirol, 2023 Depression is a common illness in people with HIV (PWH) and is associated with substantial morbidity and mortality. The mechanisms that underpin depression in PWH remain incompletely elucidated, and more research is therefore needed to develop effective ...
Fu R +11 more
europepmc +2 more sources
Pre-gestational stress reduces the ratio of 5-HIAA to 5-HT and the expression of 5-HT1A receptor and serotonin transporter in the brain of foetal rat [PDF]
BMC Neuroscience, 2012 Background Many studies have found that stress before or during pregnancy is linked to an increased incidence of behavioural disorders in offspring.
Huang Yuejun +5 more
doaj +2 more sources
Antioxidants, 2021 The incidence of vancomycin-associated acute kidney injury (VAKI) varies from 5–43%, and early detection of VAKI is important in deciding whether to discontinue nephrotoxic agents.
Hyun-Seung Lee +4 more
doaj +1 more source
Frontiers in Medicine, 2021 Acute respiratory distress syndrome (ARDS) is characterized by dysregulated vascular permeability. The clinical outcomes remain poor, and the disease burden is widespread.
Takeshi Tanaka +5 more
doaj +1 more source
The Value of Repeat 5-HIAA Measurements as a Predictor of Carcinoid Heart Disease: A Prospective 5-Year Follow-Up Study in Patients with Small Intestinal Neuroendocrine Tumors. [PDF]
Cancers (Basel)Background: Small intestinal neuroendocrine tumors (SI-NETs) are characterized by carcinoid syndrome and carcinoid heart disease (CHD). The aim of the present study was to identify early risk markers for carcinoid heart disease and survival in a ...
Kostiainen I +8 more
europepmc +2 more sources
Revista Brasileira de Reumatologia, 2013 Avaliar os efeitos do treinamento aeróbico e do alongamento sobre os níveis séricos de serotonina (5-HT) e seu principal metabólito ácido 5-hidroxiindolacético (5-HIAA).
Valéria Valim +7 more
doaj +1 more source