Results 201 to 210 of about 12,448,100 (233)

Preservation of 5-Hydroxymethylcytosine Levels in LRIG1 across Genomic DNA and Cell-Free DNA in Glioma Patients. [PDF]

Genes (Basel)
Jevšinek Skok D, Bolha L, Hauptman N.
europepmc   +1 more source

Association of tet methylcytosine dioxygenase 2 and 5-hydroxymethylcytosine in endometrioid adenocarcinoma and its clinical significance. [PDF]

BMC Womens Health
Kuang L, Zhang J, Li Y, Wang Q, Liu J, Zhang B.   +5 more
europepmc   +1 more source

The Role of 5-Hydroxymethylcytosine as a Potential Epigenetic Biomarker in a Large Series of Thyroid Neoplasms. [PDF]

Endocr Pathol
Canberk S, Gonçalves J, Rios E, Povoa AA, Tastekin E, Sobrinho-Simões M, Uguz A, Aydin O, Ince U, Soares P, Máximo V.   +10 more
europepmc   +1 more source

Ultrasensitive detection of 5-hydroxymethylcytosine in genomic DNA using a graphene-based sensor modified with biotin and gold nanoparticles. [PDF]

Mater Today Bio
Imran H, Lee HJ, Alam A, An J, Ko M, Lim S.   +5 more
europepmc   +1 more source

HM-DyadCap – Capture and Mapping of 5-Hydroxymethylcytosine/5-Methylcytosine CpG Dyads in Mammalian DNA

Engelhard L, Schiller D, Zambrano-Mila MS, Keliuotyte K, Buchmuller B, Tiwari S, Imig J, Simeone A, Schröter C, Becker S, Summerer D.   +10 more
europepmc   +1 more source

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5-Hydroxymethylcytosine and disease

Mutation Research/Reviews in Mutation Research, 2014
Epigenetics is the study of inherited changes in phenotype or gene expression that do not alter DNA sequence. Recently, scientists have focused their attention on 5-hydroxymethylcytosine (5hmC), a newly discovered epigenetic marker, also known as sixth DNA base of the genome.
Jingyu, Wang, Jinlong, Tang, Maode, Lai, Honghe, Zhang   +3 more
openaire   +2 more sources

Punicalagin Attenuates Neuronal Apoptosis by Upregulating 5-Hydroxymethylcytosine in the Diabetic Mouse Brain.

Journal of Agricultural and Food Chemistry, 2022
Punicalagin exerts neuroprotective activity by improving AMP-activated kinase (AMPK) and mitochondrial Krebs cycle. AMPK and Krebs cycle metabolites regulate 5-hydroxymethylcytosine (5hmC) via acting on ten-eleven translocation (TET) enzymes.
Xin-Liang He, Shengjie Pei, Xiang-jian Meng, Qinglian Hua, Tianyu Zhang, Yan Wang, Zhizhao Zhang, Xinyu Zhu, Run Liu, Yurong Guo, Lei Chen, Duo Li   +11 more
semanticscholar   +1 more source

Programmable Sensors of 5-Hydroxymethylcytosine

Journal of the American Chemical Society, 2015
5-Hydroxymethylcytosine (hmC), the sixth base of the mammalian genome, is increasingly recognized as an epigenetic mark with important biological functions. We report engineered, programmable transcription-activator-like effectors (TALEs) as the first DNA-binding receptor molecules that provide direct, individual selectivities for cytosine (C), 5 ...
Grzegorz, Kubik, Sabrina, Batke, Daniel, Summerer   +2 more
openaire   +2 more sources

5-Hydroxymethylcytosine-selective oxidation with peroxotungstate

Chemical Communications, 2011
Tungsten oxidation worked as a simple chemical reaction for the effective detection of 5-hydroxymethylcytosine in DNA, distinguishing it from its epigenetic precursors, 5-methylcytosine and unmethylated cytosine. The tungsten-oxidation product obtained from 5-hydroxymethylcytosine was trihydroxylated thymine and was detected as a cleavage band in gel ...
Akimitsu, Okamoto, Kaori, Sugizaki, Akiko, Nakamura, Hiroyuki, Yanagisawa, Shuji, Ikeda   +4 more
openaire   +2 more sources

Role of 5-hydroxymethylcytosine in neurodegeneration

Gene, 2015
The recent discovery of 5-hydroxymethylcytosine (5hmC), an epigenetic modifier and oxidation product of 5-methylcytosine (5mC), has broadened the scope and understanding of neural development and neurodegenerative diseases. By virtue of their functional groups, 5mC and 5hmC exert opposite effects on gene expression; the former is generally associated ...
Shariq I, Sherwani, Haseeb A, Khan
openaire   +2 more sources