Results 181 to 190 of about 16,942 (208)
Some of the next articles are maybe not open access.
[Progress of research on 5-hydroxymethylcytosine].
Yi chuan = Hereditas, 20125-methylcytosine (5mC) in cytosine-guanine dinucleotide (CpG) is a usual epigenetic modification in mammals. It plays crucial roles in gene regulation, development, genomic imprinting and so on. In the last three years, it was discovered that in addition to 5mC, another modified cytosine base-5-hydroxymethylcytosine (5hmC) was abundant in many ...
Yan-Xia, Zhang +2 more
openaire +3 more sources
Efficient Synthesis of 5-Hydroxymethylcytosine Containing DNA
Organic Letters, 20105-Hydroxymethylcytosine ((5-HOMe)dC) was recently discovered as the sixth base in the mammalian genome. The development of a new phosphoramidite building block is reported, which allows efficient synthesis of (5-HOMe)dC containing DNA. Key steps of the synthesis are a palladium-catalyzed formylation and the simultaneous protection of a hydroxyl and ...
Münzel M +3 more
openaire +3 more sources
Perturbations of 5-Hydroxymethylcytosine Patterning in Hematologic Malignancies
Seminars in Hematology, 2013The recent identification of covalent cytosine modifications derived from the metabolism of 5-methylcytosine (5-mC) and catalyzed by the TET proteins has facilitated molecular insight into a new subclass of acute myeloid leukemias (AMLs). TET2-mutant AMLs have the predicted hypermethylation phenotype expected given the inability of the mutant TET2 ...
Jozef, Madzo +2 more
openaire +2 more sources
5-Hydroxymethylcytosine: a Potential Therapeutic Target in Cancer
Epigenomics, 2014The ten-eleven translocation enzymes catalyze the conversion of 5-methylcytosine to 5-hydroxymethylcytosine, a distinct epigenetic mark that has an integral role in active demethylation. Genes that regulate the distribution and amount of 5-hydroxymethylcytosine in the genome could be suitable therapeutic targets to correct abnormal methylation in ...
Euan J, Rodger +2 more
openaire +2 more sources
Nonenzymatic Labeling of 5‐Hydroxymethylcytosine in Nanopore Sequencing
ChemBioChem, 2013Labeling chemically for a "single" result: A one-step, nonenzymatic 5hmC thiolation method mediated by bisulfite is highlighted. The 5hmC base can be chemically labeled in single-stranded DNA and detected by using nanopore sequencing.
Xingyu, Lu, Chuan, He
openaire +2 more sources
Spectroscopic Quantification of 5-Hydroxymethylcytosine in Genomic DNA
Analytical Chemistry, 20145-Hydroxymethylcytosine (5hmC), a modified form of the DNA base cytosine, is an important epigenetic mark linked to regulation of gene expression in development, and tumorigenesis. We have developed a spectroscopic method for a global quantification of 5hmC in genomic DNA.
Tamar Shahal +5 more
openaire +2 more sources
Altered 5-Hydroxymethylcytosine Landscape in Primary Gastric Adenocarcinoma
DNA and Cell Biology, 2019Multiple factors, including genetic and epigenetic fluctuations, have been linked to gastric cancer formation and progression. Cytosine methylation (5mC) has been recognized as a critical epigenetic mark in the mammalian genome. The recent discovery of 5-hydroxymethylcytosine (5hmC), which is generated by ten-eleven translocation (TET) enzymes ...
Hao, Liu +8 more
openaire +2 more sources
5-Hydroxymethylcytosine-containing Klebsiella bacteriophage
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1969N I, Anisymova +3 more
openaire +2 more sources
Enzymatic Labeling of 5‐Hydroxymethylcytosine in DNA
Angewandte Chemie International Edition, 2011openaire +3 more sources
Synthesis of 5-Hydroxymethylcytosine
Journal of the American Chemical Society, 1955openaire +1 more source