Results 161 to 170 of about 8,428,479 (200)

Distinctive Patterns of 5-Methylcytosine and 5-Hydroxymethylcytosine in Schizophrenia. [PDF]

Int J Mol Sci
Xie J, Wang Y, Ye C, Li XJ, Lin L.
europepmc   +1 more source

5-Hydroxymethylcytosine in Cell-Free DNA Predicts Immunotherapy Response in Lung Cancer. [PDF]

Cells
Shao J, Xu Y, Olsen RJ, Kasparian S, Sun K, Mathur S, Zhang J, He C, Chen SH, Bernicker EH, Li Z.   +10 more
europepmc   +1 more source

Alterations of 5-Hydroxymethylcytosine in Human Cancers [PDF]

Cancers, 2013
Prior to 2009, 5-methylcytosine (5-mC) was thought to be the only biologically significant cytosine modification in mammalian DNA. With the discovery of the TET enzymes, which convert 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC), however, intense interest has emerged in determining the biological function of 5-hmC.
Józef Madzo, Erika L Moen, Lucy A Godley   +2 more
exaly   +4 more sources

Formation and Abundance of 5‐Hydroxymethylcytosine in RNA [PDF]

ChemBioChem, 2015
AbstractRNA methylation is emerging as a regulatory RNA modification that could have important roles in the control and coordination of gene transcription and protein translation. Herein, we describe an in vivo isotope‐tracing methodology to demonstrate that the ribonucleoside 5‐methylcytidine (m5C) is subject to oxidative processing in mammals ...
Sabrina M Huber, Pieter Van Delft, Martin Bachman   +2 more
exaly   +3 more sources

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5‐Hydroxymethylcytosine, the Sixth Base of the Genome

Angewandte Chemie - International Edition, 2011
Abstract5‐Hydroxymethylcytosine (hmC) was recently discovered as a new constituent of mammalian DNA. Besides 5‐methylcytosine (mC), it is the only other modified base in higher organisms. The discovery is of enormous importance because it shows that the methylation of cytosines to imprint epigenetic information is not a final chemical step that leads ...
Martin Münzel, Daniel Globisch, Thomas Carell   +2 more
exaly   +4 more sources

5-Hydroxymethylcytosine and disease

Mutation Research/Reviews in Mutation Research, 2014
Epigenetics is the study of inherited changes in phenotype or gene expression that do not alter DNA sequence. Recently, scientists have focused their attention on 5-hydroxymethylcytosine (5hmC), a newly discovered epigenetic marker, also known as sixth DNA base of the genome.
Jingyu, Wang, Jinlong, Tang, Maode, Lai, Honghe, Zhang   +3 more
openaire   +2 more sources

Role of 5-hydroxymethylcytosine in neurodegeneration

Gene, 2015
The recent discovery of 5-hydroxymethylcytosine (5hmC), an epigenetic modifier and oxidation product of 5-methylcytosine (5mC), has broadened the scope and understanding of neural development and neurodegenerative diseases. By virtue of their functional groups, 5mC and 5hmC exert opposite effects on gene expression; the former is generally associated ...
Shariq I, Sherwani, Haseeb A, Khan
openaire   +2 more sources

The role of 5-hydroxymethylcytosine in melanoma

Melanoma Research, 2017
Malignant melanoma is a highly aggressive neoplasia of melanocytic origin. In part because of the lack of effective treatment methods, the incidence and mortality rates of this disease continue to increase. Rapidly accumulating evidence suggests that dysregulation of epigenetic mechanisms, including DNA methylation/demethylation, chromatin modification,
Feng-Juan, Li, Li-Ming, Li, Rui-Hua, Zhang, Cui, Xu, Pan, Zhou, Jia, Long, Gang, Hu, Ming-Jun, Jiang   +7 more
openaire   +2 more sources

Programmable Sensors of 5-Hydroxymethylcytosine

Journal of the American Chemical Society, 2015
5-Hydroxymethylcytosine (hmC), the sixth base of the mammalian genome, is increasingly recognized as an epigenetic mark with important biological functions. We report engineered, programmable transcription-activator-like effectors (TALEs) as the first DNA-binding receptor molecules that provide direct, individual selectivities for cytosine (C), 5 ...
Grzegorz, Kubik, Sabrina, Batke, Daniel, Summerer   +2 more
openaire   +2 more sources

5-Hydroxymethylcytosine-selective oxidation with peroxotungstate

Chemical Communications, 2011
Tungsten oxidation worked as a simple chemical reaction for the effective detection of 5-hydroxymethylcytosine in DNA, distinguishing it from its epigenetic precursors, 5-methylcytosine and unmethylated cytosine. The tungsten-oxidation product obtained from 5-hydroxymethylcytosine was trihydroxylated thymine and was detected as a cleavage band in gel ...
Akimitsu, Okamoto, Kaori, Sugizaki, Akiko, Nakamura, Hiroyuki, Yanagisawa, Shuji, Ikeda   +4 more
openaire   +2 more sources