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The Elusive Role of 5′-Hydroxymethylcytosine
Epigenomics, 20165'-hydroxymethylcytosine (5hmC) is a variant of the common covalent epigenetic modification of DNA 5'-methylcytosine (5mC). Although the presence of this modified base in mammalian DNA has been recognized for several decades, it has recently gained center stage as a suspected intermediate in enzymatic active demethylation of 5mC.
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Uncovering the role of 5-hydroxymethylcytosine in the epigenome
Nature Reviews Genetics, 2011Just over 2 years ago, TET1 was found to catalyse the oxidation of 5-methylcytosine, a well-known epigenetic mark, into 5-hydroxymethylcytosine in mammalian DNA. The exciting prospect of a novel epigenetic modification that may dynamically regulate DNA methylation has led to the rapid accumulation of publications from a wide array of fields, from ...
Miguel R. Branco +2 more
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[Progress of research on 5-hydroxymethylcytosine].
Yi chuan = Hereditas, 20125-methylcytosine (5mC) in cytosine-guanine dinucleotide (CpG) is a usual epigenetic modification in mammals. It plays crucial roles in gene regulation, development, genomic imprinting and so on. In the last three years, it was discovered that in addition to 5mC, another modified cytosine base-5-hydroxymethylcytosine (5hmC) was abundant in many ...
Yan-Xia, Zhang +2 more
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5-hydroxymethylcytosine in cancer: significance in diagnosis and therapy
Cancer Genetics, 2015Emerging data have demonstrated that 5-methylcytosine (5-mC) and its oxidized products 5-hydroxymethylcytosine (5-hmC), 5-formylcytosine (5-fC), and 5-carboxylcytosine (5-CaC) play unique roles in several biological processes, including the control of gene expression and in the pathogenesis of cancer.
Aparna Vasanthakumar, Lucy A Godley
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5-Hydroxymethylcytosine: a Potential Therapeutic Target in Cancer
Epigenomics, 2014The ten-eleven translocation enzymes catalyze the conversion of 5-methylcytosine to 5-hydroxymethylcytosine, a distinct epigenetic mark that has an integral role in active demethylation. Genes that regulate the distribution and amount of 5-hydroxymethylcytosine in the genome could be suitable therapeutic targets to correct abnormal methylation in ...
Euan J Rodger +2 more
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5-Hydroxymethylcytosine Profiling in Human DNA
2015Since its "re-discovery" in 2009, there has been significant interest in defining the genome-wide distribution of DNA marked by 5-hydroxymethylation at cytosine bases (5hmC). In recent years, technological advances have resulted in a multitude of unique strategies to map 5hmC across the human genome.
John P, Thomson +2 more
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Efficient Synthesis of 5-Hydroxymethylcytosine Containing DNA
Organic Letters, 20105-Hydroxymethylcytosine ((5-HOMe)dC) was recently discovered as the sixth base in the mammalian genome. The development of a new phosphoramidite building block is reported, which allows efficient synthesis of (5-HOMe)dC containing DNA. Key steps of the synthesis are a palladium-catalyzed formylation and the simultaneous protection of a hydroxyl and ...
Münzel M +3 more
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Perturbations of 5-Hydroxymethylcytosine Patterning in Hematologic Malignancies
Seminars in Hematology, 2013The recent identification of covalent cytosine modifications derived from the metabolism of 5-methylcytosine (5-mC) and catalyzed by the TET proteins has facilitated molecular insight into a new subclass of acute myeloid leukemias (AMLs). TET2-mutant AMLs have the predicted hypermethylation phenotype expected given the inability of the mutant TET2 ...
Jozef, Madzo +2 more
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Nonenzymatic Labeling of 5‐Hydroxymethylcytosine in Nanopore Sequencing
ChemBioChem, 2013Labeling chemically for a "single" result: A one-step, nonenzymatic 5hmC thiolation method mediated by bisulfite is highlighted. The 5hmC base can be chemically labeled in single-stranded DNA and detected by using nanopore sequencing.
Xingyu, Lu, Chuan, He
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Advances in DNA methylation: 5-hydroxymethylcytosine revisited
Clinica Chimica Acta, 2011Mammalian DNA contains two modified cytosine bases; 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC). Both of these have been known for decades but have received very different levels of attention in the scientific literature. 5mC has been studied extensively, and its role as an epigenetic modification involved in gene regulation, X-chromosome
Christina, Dahl +2 more
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