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5‐Hydroxymethylcytosine, the Sixth Base of the Genome
Angewandte Chemie - International Edition, 2011Abstract5‐Hydroxymethylcytosine (hmC) was recently discovered as a new constituent of mammalian DNA. Besides 5‐methylcytosine (mC), it is the only other modified base in higher organisms. The discovery is of enormous importance because it shows that the methylation of cytosines to imprint epigenetic information is not a final chemical step that leads ...
Martin Münzel +2 more
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5‐Hydroxymethylcytosine: a new kid on the epigenetic block?
Molecular Systems Biology, 2011 The discovery of the Ten‐Eleven‐Translocation (TET) oxygenases that catalyze the hydroxylation of 5‐methylcytosine (5mC) to 5‐hydroxymethylcytosine (5hmC) has triggered an avalanche of studies aiming to resolve the role of 5hmC in gene regulation if any.
Enrique Carrillo-de Santa Pau +1 more
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5-Hydroxymethylcytosine and disease
Mutation Research/Reviews in Mutation Research, 2014Epigenetics is the study of inherited changes in phenotype or gene expression that do not alter DNA sequence. Recently, scientists have focused their attention on 5-hydroxymethylcytosine (5hmC), a newly discovered epigenetic marker, also known as sixth DNA base of the genome.
Jingyu, Wang +3 more
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Programmable Sensors of 5-Hydroxymethylcytosine
Journal of the American Chemical Society, 20155-Hydroxymethylcytosine (hmC), the sixth base of the mammalian genome, is increasingly recognized as an epigenetic mark with important biological functions. We report engineered, programmable transcription-activator-like effectors (TALEs) as the first DNA-binding receptor molecules that provide direct, individual selectivities for cytosine (C), 5 ...
Grzegorz, Kubik +2 more
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5-Hydroxymethylcytosine-selective oxidation with peroxotungstate
Chemical Communications, 2011Tungsten oxidation worked as a simple chemical reaction for the effective detection of 5-hydroxymethylcytosine in DNA, distinguishing it from its epigenetic precursors, 5-methylcytosine and unmethylated cytosine. The tungsten-oxidation product obtained from 5-hydroxymethylcytosine was trihydroxylated thymine and was detected as a cleavage band in gel ...
Akimitsu, Okamoto +4 more
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Role of 5-hydroxymethylcytosine in neurodegeneration
Gene, 2015The recent discovery of 5-hydroxymethylcytosine (5hmC), an epigenetic modifier and oxidation product of 5-methylcytosine (5mC), has broadened the scope and understanding of neural development and neurodegenerative diseases. By virtue of their functional groups, 5mC and 5hmC exert opposite effects on gene expression; the former is generally associated ...
Shariq I, Sherwani, Haseeb A, Khan
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Advances in DNA methylation: 5-hydroxymethylcytosine revisited
Clinica Chimica Acta, 2011Mammalian DNA contains two modified cytosine bases; 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC). Both of these have been known for decades but have received very different levels of attention in the scientific literature. 5mC has been studied extensively, and its role as an epigenetic modification involved in gene regulation, X-chromosome
Christina, Dahl +2 more
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The Elusive Role of 5′-Hydroxymethylcytosine
Epigenomics, 20165'-hydroxymethylcytosine (5hmC) is a variant of the common covalent epigenetic modification of DNA 5'-methylcytosine (5mC). Although the presence of this modified base in mammalian DNA has been recognized for several decades, it has recently gained center stage as a suspected intermediate in enzymatic active demethylation of 5mC.
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5-Hydroxymethylcytosine Profiling in Human DNA
2015Since its "re-discovery" in 2009, there has been significant interest in defining the genome-wide distribution of DNA marked by 5-hydroxymethylation at cytosine bases (5hmC). In recent years, technological advances have resulted in a multitude of unique strategies to map 5hmC across the human genome.
John P, Thomson +2 more
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The role of 5-hydroxymethylcytosine in melanoma
Melanoma Research, 2017Malignant melanoma is a highly aggressive neoplasia of melanocytic origin. In part because of the lack of effective treatment methods, the incidence and mortality rates of this disease continue to increase. Rapidly accumulating evidence suggests that dysregulation of epigenetic mechanisms, including DNA methylation/demethylation, chromatin modification,
Feng-Juan, Li +7 more
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