Results 51 to 60 of about 250,662 (244)

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng   +7 more
wiley   +1 more source

78 543 habitants [PDF]

open access: yesLa piscine en textes et en images, 2020
Titre de la chanson : 78 543 habitants Compositeur : Vincent Delerm (*1976) Texte : Vincent Delerm Interprète : Vincent Delerm (chant) Année : 2008 Album :  Quinze chansons (piste 8) Label : Tôt ou tard Pays : France Genre : chanson francophone Mots ...
Anne-Sophie Gomez
openaire   +3 more sources

Leidenschaften [543/544] [PDF]

open access: yes, 1927
LEIDENSCHAFTEN [543/544] Leidenschaften [543/544] ( - ) Cover ( - ) Title page ([1]) Imprint ([1]) [Druckhinweis] ([2]) Inhaltsverzeichnis. ([3]) Das Attentat.

core  

Characteristics of the study population (n = 543). [PDF]

open access: yes, 2019
Characteristics of the study population (n = 543).
Deepa Gunasekara (411785)   +6 more
core   +1 more source

Curvature‐Controlled Field Effect Enables Thermal Localization for Low‐Temperature C─F Bond Activation

open access: yesAdvanced Science, EarlyView.
High‐curvature γ‐Al2O3 nanoneedles concentrate heat into nanoscale hotspots under identical external heating, amplifying local temperature and accelerating CF4 decomposition. By linking curvature‐induced thermal localization to lower apparent activation barriers and enhanced intermediate formation, this work reveals geometry as a powerful design ...
Hang Zhang   +12 more
wiley   +1 more source

Quantum Noise: Particles, Waves and Mixture

open access: yesApplied Sciences
We carry out a theoretical investigation about quantum noise in coherent mixtures of states with different statistics. On the one hand, we investigate the dependence between the behavior wave-particle and associated noise.
Leonardo López-Hernández   +7 more
doaj   +1 more source

ZNF281-miR-543 Feedback Loop Regulates Transforming Growth Factor-β-Induced Breast Cancer Metastasis

open access: yesMolecular Therapy: Nucleic Acids, 2020
Breast cancer is the most common malignancy, and metastasis is the main cause of cancer-associated mortality in women worldwide. Transforming growth factor-β (TGF-β) signaling, an inducer of epithelial-to-mesenchymal transition (EMT), plays an important ...
Wei Ji   +4 more
doaj   +1 more source

Identification of Extended Emission Gamma-Ray Burst Candidates Using Machine Learning

open access: yesThe Astrophysical Journal, 2023
Gamma-ray bursts (GRBs) have been classified traditionally based on their duration. The increasing number of extended emission (EE) GRBs, lasting typically more than 2s but with properties similar to those of short GRBs, challenges the traditional ...
K. Garcia-Cifuentes   +4 more
doaj   +1 more source

Multi‐tissue Metabolic GWAS and Drought‐Responsive Multi‐omics Reveal the Genetic Basis of the Quinoa Metabolome

open access: yesAdvanced Science, EarlyView.
A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
Julia von Steimker   +11 more
wiley   +1 more source

Two‐Dimensional Conjugated Metal Organic Frameworks with Dual Metal Catalytic Active Sites Enhance POD Activity for Antibacterial Treatment

open access: yesAdvanced Science, EarlyView.
A new class of Cu, Ni bimetallic 2D cMOF (CuNi‐HHTP 2D cMOF) featuring dual catalytic sites and high delocalized electronic structure for boosting POD performance. The CuNi‐HHTP 2D‐cMOF enhances the conversion kinetics of H2O2 to ROS, which subsequently enhances antibacterial activity and accelerates the healing of oral ulcers, with macroscopic wound ...
Yixuan Lu   +9 more
wiley   +1 more source

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