Results 51 to 60 of about 539,525 (284)

CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome

Advanced Science, EarlyView.
By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Siyu Chen, Zhiquan Liu, Wenmin Wang, Qing Wang, Tia J. Kowal, Fan Zhang, Grzegorz Walkiewicz, Faruk Hossen, Herbert M. Lachman, Jinqiong Zhou, Yiting Wang, Yang Sun   +11 more
wiley   +1 more source

Small Mouse Islets Are Deficient in Glucagon-Producing Alpha Cells but Rich in Somatostatin-Secreting Delta Cells

Journal of Diabetes Research, 2016
Small and big mouse islets were compared with special reference to their content of glucagon-producing α-cells and somatostatin-producing δ-cells. Areas stained for glucagon and somatostatin were measured in the largest cross section of small (diameter <
Joey Lau, Eva Grapengiesser, Bo Hellman
doaj   +1 more source

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

Animal‐Based Brands Taking the Plant‐Based Opportunity: A Tasting Experiment Exploring Consumer Acceptance of Plant‐Based Brand Extensions

Agribusiness, EarlyView.
ABSTRACT This study investigates how consumer taste and brand equity perceptions shape the acceptance of plant‐based milk products. Using a blind/informed tasting experiment, we evaluated consumers' willingness to buy (WTB) and taste perception of a plant‐based milk alternative produced by a traditional dairy brand, compared with competing plant‐based ...
Federico Parmiggiani, Mirta Casati, Elena Castellari, Fosca Vezzulli, Veronica Vitali, Milena Lambri, Claudio Soregaroli   +6 more
wiley   +1 more source

Diagnostic damage symptoms and distribution of avocado stem borer (Zeuzera spp.) in the Western Ghats region of India

The Indian Journal of Agricultural Sciences
Avocado (Persea americana Mill.), a high-value exotic fruit, is gaining popularity in India due to its nutritional, pharmaceutical, and industrial applications.
A T RANI, G S MADHU, B M MURALIDHARA, G NAYAN DEEPAK, S RAJENDIRAN, V RAKSHITH   +5 more
doaj   +1 more source

Cost‐Benefit Analysis of the European Union Carbon Border Adjustment Mechanism in Fertilizer Trade

Agribusiness, EarlyView.
ABSTRACT The carbon border adjustment mechanism (CBAM), launching 2026, will charge EU importers for embedded carbon emissions, aiming to reduce emissions but raising import costs. Shifts in demand following implementation may reduce carbon emissions, but importers will bear the cost of increased prices.
Natalie Crisci, Md Deluair Hossen, Andrew Muhammad, Seong‐Hoon Cho   +3 more
wiley   +1 more source

Noninvasive tests for nonalcoholic fatty liver disease in a multi‐ethnic population: The HELIUS study

Hepatology Communications, EarlyView., 2022
Abstract Nonalcoholic fatty liver disease (NAFLD) is increasing in prevalence and severity globally, prompting noninvasive testing, yet limited data exist on noninvasive liver tests (NITs) including transient elastography (TE) in ethnically diverse populations.
Anne‐Marieke van Dijk, Yasaman Vali, Anne Linde Mak, Henrike Galenkamp, Max Nieuwdorp, Bert‐Jan van den Born, Adriaan Georgius Holleboom   +6 more
wiley   +1 more source

Searching for an interstellar medium association for HESS J1534 - 571 [PDF]

, 2018
The Galactic supernova remnant HESS J1534-571 (also known as G323.7-1.0) has a shell-like morphology in TeV gamma-ray emission and is a key object in the study of cosmic ray origin. Little is known about its distance and local environment.
Maxted, Nigel I. (R19203), Voisin, Fabien, Sano, Hidetoshi, Vukotić, Branislav, Pavlović, Marko Z., Braiding, Catherine, Burton, Michael G., Rowell, Gavin, Filipovic, Miroslav (R7673), Wong, Graeme F. (S30630), Urošević, Dejan, Fukui, Yasuo   +11 more
core   +2 more sources

Austrocedrus from the Late Cretaceous of Antarctica and its implications for the early evolution of southern cypresses (Callitroideae, Cupressaceae)

American Journal of Botany, EarlyView.
Abstract Premise The modern distribution of the southern cypresses, Callitroideae (Cupressaceae), reflects a classic Gondwanan distribution. The initial diversification of Callitroideae is estimated to have occurred during the Cretaceous, yet fossils from this period are rare, hampering our understanding of its early evolutionary history.
Kelly C. Pfeiler, Kelly K. S. Matsunaga, Ana Andruchow‐Colombo, Ari Iglesias, Selena Y. Smith, Brian A. Atkinson   +5 more
wiley   +1 more source

Isotopic characterization and mass balance reveals groundwater recharge pattern in Chaliyar river basin, Kerala, India

Journal of Hydrology: Regional Studies, 2015
Study region: The Chaliyar river basin, Kerala State, India. Study focus: Detailed understanding about spatio-temporal variation in the interaction and exchange of water between surface and sub-surface reservoirs is important for effective watershed ...
A. Shahul Hameed, T.R. Resmi, S. Suraj, C. Unnikrishnan Warrier, M. Sudheesh, R.D. Deshpande   +5 more
doaj   +1 more source