Results 21 to 30 of about 1,318,093 (377)

Rutin attenuates Sorafenib-induced Chemoresistance and Autophagy in Hepatocellular Carcinoma by regulating BANCR/miRNA-590-5P/OLR1 Axis

International Journal on Biological Sciences, 2021
Rutin, the main component of Potentilla discolor Bunge, was proven to exhibit anti-tumor properties. Sorafenib (SO) is conventionally used in chemotherapy against hepatocellular carcinoma (HCC), but acquired resistance developed during long-term therapy ...
Meng Zhou, Gan Zhang, Jun Hu, Yanzhi Zhu, Hao-Chang Lan, Xian-Feng Shen, Yi Lv, Linsheng Huang   +7 more
semanticscholar   +1 more source

CircPUM1 promotes cell growth and glycolysis in NSCLC via up-regulating METTL3 expression through miR-590-5p

Cell Cycle, 2021
RNA pumilio RNA binding family member 1 (circPUM1) has been reported to play important roles in the tumorigenesis of several cancers. However, the underlying molecular role of circPUM1 in non-small cell lung cancer (NSCLC) progression remains unknown ...
Mingjun Li, Qian-Qian Wang, Xiaofei Zhang, N. Yan, Xingya Li   +4 more
semanticscholar   +1 more source

Long non‐coding RNA ESCCAL‐1/miR‐590/LRP6 signaling pathway participates in the progression of esophageal squamous cell carcinoma

Cancer Medicine, 2023
Background Long non‐coding RNAs (lncRNAs) have critical functions within esophageal squamous cell carcinoma (ESCC). However, the function and mechanism underlying ESCC‐associated lncRNA‐1 (ESCCAL‐1) in ESCC tumorigenesis have not been well clarified ...
Hongya Guan, Pengju Lv, Pengli Han, Lijuan Zhou, Jia Liu, Wei Wu, Ming Yan, Qinghe Xing, Wei Cao   +8 more
doaj   +1 more source

MiR-590 Suppresses Proliferation and Induces Apoptosis in Pancreatic Cancer by Targeting High Mobility Group A2

Technology in Cancer Research & Treatment, 2020
Background: Pancreatic ductal adenocarcinoma is a common malignancy with high morbidity. MicroRNAs have been demonstrated to be critical posttranscriptional regulators in tumorigenesis.
Ya-Dong Wang MD, Jia-Ding Mao PhD, Jun-Feng Wang MD, Mao-Qi Xu MD   +3 more
doaj   +1 more source

MicroRNA‐590‐3p inhibits T helper 17 cells and ameliorates inflammation in lupus mice

Immunology, 2021
T helper 17 (Th17) cells have a pathogenic effect in many autoimmune diseases. Inhibition of Th17 cells can alleviate the inflammatory damage in autoimmune diseases.
Jun-jun Huang, Xinzhi Xu, Xiuyuan Wang, Jie Yang, Meijuan Xue, Yiming Yang, Ruomei Zhang, Xue Yang, Ji Yang   +8 more
semanticscholar   +1 more source

Functional role and epithelial to mesenchymal transition of the miR-590-3p/MDM2 axis in hepatocellular carcinoma

BMC Cancer, 2023
Background There is considerable evidence that microRNAs (miRNAs) regulate several key tumor-associated genes/pathways and may themselves have a dual regulatory function either as tumor suppressors or oncogenic miRNA, depending on the tumor type ...
Alaa Ibrahem Youssef, Gehad Mahmoud Khaled, Asma Amleh   +2 more
doaj   +1 more source

The Changing-look Quasar Mrk 590 Is Awakening [PDF]

The Astrophysical Journal, 2018
Abstract Mrk 590 was originally classified as a Seyfert 1 galaxy, but then it underwent dramatic changes: the nuclear luminosity dropped by over two orders of magnitude and the broad emission lines all but disappeared from the optical spectrum. Here we present follow-up observations to the original discovery and characterization of this “
G. De Rosa, M. R. Goad, Fabrizio Nicastro, Smita Mathur, Kelly D. Denney, B. M. Peterson, B. M. Peterson, J. Collinson, Yair Krongold, Marianne Vestergaard, Marianne Vestergaard, A. Gupta, A. Gupta, Richard W. Pogge, Kirk T. Korista   +14 more
openaire   +4 more sources

The miR-590/Acvr2a/Terf1 Axis Regulates Telomere Elongation and Pluripotency of Mouse iPSCs

Stem Cell Reports, 2018
Summary: During reprogramming, telomere re-elongation is important for pluripotency acquisition and ensures the high quality of induced pluripotent stem cells (iPSCs), but the regulatory mechanism remains largely unknown.
Qidong Liu, Guiying Wang, Yao Lyu, Mingliang Bai, Zeyidan Jiapaer, Wenwen Jia, Tong Han, Rong Weng, Yiwei Yang, Yangyang Yu, Jiuhong Kang   +10 more
doaj   +1 more source

LncRNA ZEB1-AS1 knockdown alleviates oxidative low-density lipoprotein-induced endothelial cell injury via the miR-590-5p/ HDAC9 axis

Central European Journal of Immunology, 2021
Oxidative low-density lipoprotein (ox-LDL) is thought to induce vascular endothelial cell injury, which contributes to the aetiopathogenesis of atherosclerosis (AS).
Jinpeng Zhong, Bin Cheng, Li Yang, Guanlan Li, Yunzhong Yuan, Gang Luo, Zhiping Shu, Hong Jiang   +7 more
doaj   +1 more source

Long non-coding RNA FAM225A promotes nasopharyngeal carcinoma tumorigenesis and metastasis by acting as ceRNA to sponge miR-590-3p/miR-1275 and upregulate ITGB3.

Cancer Research, 2019
Long non-coding RNAs (lncRNAs) play important roles in the tumorigenesis and progression of cancers. However, the clinical significance of lncRNAs and their regulatory mechanisms in nasopharyngeal carcinogenesis (NPC) are largely unknown.
Zi-Qi Zheng, Zhi-Xuan Li, G. Zhou, Li Lin, Lulu Zhang, J. Lv, Xiao-Dan Huang, Rui-Qi Liu, Fo-Ping Chen, Xiao-Jun He, J. Kou, J. Zhang, Xin Wen, Yingqin Li, Jun Ma, Na Liu, Ying Sun   +16 more
semanticscholar   +1 more source