Results 171 to 180 of about 32,355 (207)
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Prevention of 6-hydroxydopamine neurotoxicity
European Journal of Pharmacology, 19751-Phenyl-3-(2-thiazolyl)-2-thiourea (PTTU) prevented the neurotoxic actions of 6-hydroxydopamine on adrenergic nerves in the mouse atrium and iris. This is the first reported 6-hydroxydopamine antagonist that does not act by blocking uptake of catecholamines into nerve terminals. PTTU also prevented the diabetogenic action of alloxan.
G, Cohen +4 more
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Central effects of 6-hydroxydopamine
Physiology & Behavior, 1971Abstract The central effects of 6-hydroxydopamine (6-OHDA) injected intracerebrally in mice and intracisternally in rats have been studied. Mice treated with 100 μg of the drug were sedated and lethargic, with reduced spontaneous activity, for periods of up to 8 days after injection. For a similar period, the response to amphetamine consisted only of
A S, De Carolis +3 more
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Psychopharmacology, 1980
After intracisternal 6-hydroxydopamine (6-OHDA) in mice, brain noradrenaline (NA) and dopamine (DA) are diminished, although the reduction of NA is more pronounced. Intracisternal injection of 6-OHDA in desmethylimipramine (DMI)-pretreated animals strengthens the depletion of DA while NA is partly protected.
V, Fuchs, H, Coper
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After intracisternal 6-hydroxydopamine (6-OHDA) in mice, brain noradrenaline (NA) and dopamine (DA) are diminished, although the reduction of NA is more pronounced. Intracisternal injection of 6-OHDA in desmethylimipramine (DMI)-pretreated animals strengthens the depletion of DA while NA is partly protected.
V, Fuchs, H, Coper
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Mechanism of 6-hydroxydopamine neurotoxicity
1997The catecholaminergic neurotoxin 6-hydroxydopamine (6-OHDA) has recently been found to be formed endogenously in patients suffering from Parkinson's disease. In this article, we highlight the latest findings on the biochemical mechanism of 6-OHDA toxicity.
Y, Glinka, M, Gassen, M B, Youdim
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6-Hydroxydopamine, a new oxidation mechanism
European Journal of Pharmacology, 1972Abstract Electrochemical and chemical studies, supported by EPR, NMR and UV evidence, show that 6-hydroxydopamine does not oxidize in vitro at physiological pH to the cyclized indoline (aminochrome) as previously believed. The implications of these results to the chemical sympathectomy actions of 6-hydroxydopamine are discussed.
R N, Adams +4 more
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Neonatal 6-hydroxydopamine alters olfactory development
Behavioral Biology, 1977The odor preferences and brain catecholamine content of Sprague-Dawley rat pups 5–16 days of age were monitored following systemic injections of 6-hydroxydopamine (6-OHDA) on Days 0–3 postpartum. During the first postnatal week, 6-OHDA produced an alteration in the development of olfactory-guided behavior which was confined to conspecific odor.
S K, Sobrian, C, Cornwell-Jones
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6-Hydroxydopamine: a far from simple neurotoxin
Journal of Neural Transmission, 20206-Hydroxydopamine (6-OHDA), which is a neurotoxin that selectively destroys catecholaminergic nerves in sympathetically innervated tissues, has been used to provide a model of Parkinson's disease in experimental animals. It is rapidly autoxidised to yield potentially toxic products and reactive oxygen species. Its ability to release Fe(II) from protein
Damir Varešlija +3 more
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6-Hydroxydopamine and Aggression in Cats
Pharmacology Biochemistry and Behavior, 1981The effect of 6-hydroxydopamine (6-OHDA) injected into the cerebral ventricles on behaviour of singly- and group-housed cats was investigated. 6-OHDA in doses of 0.5, 1 and 2 mg was administered every morning for 5 to 8 days. In small doses 6-OHDA in singly- and group-housed cats evoked motor phenomena such as tremor, ataxia, rigidity, weakness and ...
D B, Beleslin +2 more
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Central cardiovascular effects of 6-hydroxydopamine
European Journal of Pharmacology, 1972Abstract Effects of 6-hydroxydopamine (6-OHDA) on the vasomotor loci of medulla oblongata, hypothalamus and spinal cord have been investigated in anaesthetized (chloralosed) cats. Intracerebroventricular (i.c.v.) and intrathecal (i.t.) administration of 6-OHDA, 0.5–2.0 mg, inhibited reflex, as well as direct, excitability of vasomotor loci. The blood
P P, Gupta, R C, Srimal, B N, Dhawan
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The 6-Hydroxydopamine model of parkinson’s disease
Neurotoxicity Research, 2007The neurotoxin 6-hydroxydopamine (6-OHDA) continues to constitute a valuable topical tool used chiefly in modeling Parkinson's disease in the rat. The classical method of intracerebral infusion of 6-OHDA involving a massive destruction of nigrostriatal dopaminergic neurons, is largely used to investigate motor and biochemical dysfunctions in Parkinson ...
SIMOLA, NICOLA +2 more
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