Results 81 to 90 of about 32,355 (207)
Journal of Neurochemistry, Volume 170, Issue 2, February 2026.When mitochondria are damaged by MPP+, they produce excess reactive oxygen species (ROS) and release zinc (Zn2+) inside the cell. This surge in zinc overwhelms lysosomes—the cell's major zinc‐buffering organelles—causing their membranes to break down. Leaking lysosomal enzymes then trigger neuronal death. Treatments that reduce ROS, bind zinc, or block
Hyun‐Seung Lee +5 more
wiley +1 more source
Basic and Clinical Neuroscience, 2010 Parkinson’s disease (PD) is a neuropathological and debilitating disorder involving the degeneration of mesencephalic dopaminergic neurons. Neuroprotective effect of hesperetin has already been reported, therefore, this study examined whether the ...
Tourandokht Baluchnejadmojarad +1 more
doaj +2 more sources
Journal of Biomedical Science, 2011 Parkinson's disease is characterized by progressive cell death in the substantia nigra pars compacta, which leads to dopamine depletion in the striatum and indirectly to cortical dysfunction.
Romeo Chinthu +5 more
doaj +1 more source
Anti-inflammatory treatment induced regenerative oligodendrogenesis in parkinsonian mice
, 2013 Introduction: The adult mammalian brain retains niches for neural stem cells (NSCs), which can generate glial and neuronal components of the brain tissue.
Bunk, E.C. (Eva) +3 more
core +1 more source
Advanced Science, Volume 13, Issue 3, 14 January 2026.This study identifies CARD9 as a key mediator linking sympathetic β2‐adrenergic receptor signaling to macrophage creatine metabolism, inflammatory polarization, and neuronal integrity. Loss of β2‐AR‐PKA‐CREB1‐CARD9 signaling in macrophages reduces creatine uptake, promotes pro‐inflammatory macrophage activation, and drives sympathetic axon ferroptosis.
Huimin Yuan +12 more
wiley +1 more source
Molecules, 2010 6-Hydroxydopamine administration for 28 days (8 μg/2 μL) reduced the number of tyrosine hydroxylase (TH)-immunopositive neurons to 40.2% in the substantia nigra compared to the intact contralateral side.
Hyun Sook Choi +5 more
doaj +1 more source
Combination of CDNF and Deep Brain Stimulation Decreases Neurological Deficits in Late-stage Model Parkinson's Disease [PDF]
, 2018 Several neurotrophic factors ( NTF) are shown to be neuroprotective and neurorestorative in pre-clinical animal models for Parkinson's disease ( PD), particularly in models where striatal dopamine neuron innervation partially exists.
Airavaara, Mikko +10 more
core +1 more source
HUWE1 in Skeletal Muscle Prevents Muscle Fatigue via Maintaining Iron and Calcium Homeostasis
Advanced Science, Volume 13, Issue 4, 19 January 2026.This study investigates the impact of iron homeostasis on exercise. Loss of the HECT domain‐containing ubiquitin ligase E3 (HUWE1) in skeletal muscle restrains the exercise performance in mice with downregulated ferroportin expression leading to iron overload, which is ameliorated by dietary iron restriction.
Huike Jiao +10 more
wiley +1 more source
Changes in Striatal N-methyl-D-aspartate (NMDA) Stimulation of Dopamine Release and Receptor Subunit Expression During Expression of and Recovery from MPTP-Induced Parkinsonism [PDF]
, 2001 Normal and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-treated cats were used to examine changes in N-methyl-D-aspartate (NMDA) receptor function.
Desai, Dr. Anup +2 more
core
Quinone formation as dopaminergic neuron-specific oxidative stress in the pathogenesis of sporadic Parkinson's disease and neurotoxin-induced parkinsonism. [PDF]
, 2004 Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by dopaminergic neuron-specific degeneration in the substantia nigra.
Asanuma, Masato +3 more
core +1 more source