Results 151 to 160 of about 9,551,377 (187)

Investigating the Anti-Cancer Properties of 6-Shogaol in Zingiber officinale

Critical Reviews™ in Oncogenesis, 2022
Cancer is ranked as the first or second cause of death in 112 countries across the world with an estimated 19.3 million new cases of cancer along with 10 million deaths occurring in 2020. Colon cancer is the second most common cancer in women and the fourth most common cancer worldwide.
Sowsan, Hafuth, Sukhpal, Randhawa
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Cytotoxic effect of 6-Shogaol in Imatinib sensitive and resistant K562 cells

Molecular Biology Reports, 2021
Chronic Myeloid Leukemia (CML) is a clonal hematopoietic malignancy characterized by the formation of BCR-ABL fusion protein. Imatinib (IMA) is a BCR-ABL tyrosine kinase inhibitor (TKI), which exhibited a high rate of response for newly diagnosed CML patients. Emergence of IMA resistance considered as a major challenge in CML therapy.
Tulin Ozkan, Yalda Hekmatshoar, Hanife Pamuk, Merve Ozcan, Guler Yaman, Gulsah Ceylan Yagiz, Cigdem Akdemir, Asuman Sunguroglu   +7 more
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Glucuronidation and its impact on the bioactivity of [6]-shogaol

Molecular Nutrition & Food Research, 2017
-shogaol (6S) from ginger has been reported to have diverse bioactivities and can be widely metabolized in animals and humans; however, the impact of glucuronidation on its bioactivity is still largely unknown. This study investigates the glucuronidation of 6S and its effect on cell cytotoxicity and Nrf2-inducing activities of 6S.The glucuronidated ...
Pei, Wang, Yantao, Zhao, Yingdong, Zhu, Shengmin, Sang   +3 more
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Additive Capacity of [6]-Shogaol and Epicatechin To Trap Methylglyoxal

Journal of Agricultural and Food Chemistry, 2017
Methylglyoxal (MGO), a reactive dicarbonyl species, is thought to contribute to the development of long-term pathological diabetes as a direct toxin or as an active precursor of advanced glycation end products (AGEs). Trapping MGO by dietary phenols to inhibit the MGO induced AGE formation is an approach for alleviating diabetic complications.
Qiju Huang, Pei Wang, Yingdong Zhu, Lishuang Lv, Shengmin Sang   +4 more
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Ginger (Gingerols and 6-Shogaol) Against Cancer

2021
Ginger, the rhizomes of Zingiber officinale Roscoe (Zingiberaceae), is one of the most widely consumed spices worldwide due to its pungent smell and taste. It has also traditionally been used since antiquity for the treatment of ailments like common colds, fever, arthritis, rheumatism, gastrointestinal complications, motion sickness, diabetes ...
Esra Köngül Şafak, Gökçe Şeker Karatoprak   +1 more
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Interindividual Variability in Metabolism of [6]-Shogaol by Gut Microbiota

Journal of Agricultural and Food Chemistry, 2017
[6]-Shogaol (6S), one of the major bioactive components in dry ginger, is attracting considerable attention because of its wide spectrum of biological activities, but its metabolic fate is still not fully understood. In the present study, the microbial metabolism of 6S was examined for the first time in in vitro batch fecal fermentation system and in ...
Pei Wang, Ronghui Wang, Yingdong Zhu, Shengmin Sang   +3 more
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ESTABLISHMENT OF THE 6-SHOGAOL EXTRACTION PROCESS FROM 6-SHOGAOL-ENRICHED GINGER FOR CANCER TREATMENT

VietNam Military Medical Unisversity
Objectives: To optimally extract the potential phytochemical “6-shogaol” from fermented shogaol-enriched ginger. Methods: Extraction process parameters were investigated using 6-shogaol as a marker. Results: The suitable parameters of the 6-shogaol extraction process: Hot extraction using reflux equipment, solvent of 90% ethanol, solvent/herb ratio of ...
Ba Ngoc Minh Ho, Trong Diep Nguyen, Van Hien Pham, Binh Duong Vu   +3 more
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6‐Shogaol improves behavior and memory in Wistar rats prenatally exposed to lipopolysaccharide

International Journal of Developmental Neuroscience, 2021
AbstractObjective6‐Shogaol, bioactive compound of Zingiber officinale Roscoe, has anti‐inflammatory, antioxidant, and neuroprotective properties. The objective of the present study was to verify the effect of 6‐shogaol on behavioral parameters in a preclinical model based on a maternal immune activation (MIA) by lipopolysaccharide (LPS ...
Naiana da Rosa, Fabiana Durante de Medeiros, Juliana de Oliveira, Ana Olívia Martins Laurentino, Eduardo Medeiros Peretti, Richard Simon Machado, Jucélia Jeremias Fortunato, Fabrícia Petronilho   +7 more
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Biotransformation of 6-gingerol and 6-shogaol by Aspergillus niger

Phytochemistry, 1993
Abstract 6-Gingerol and shogaol, the pungent constituents of Zingiber officinalis were biotransformed by Aspergillus niger. 6-Gingerol was converted to the corresponding primary alcohol as major product although a keto group is present in the molecule whereas the double bond and keto group of 6-shogaol were reduced and the terminal methyl group was ...
Hironobu Takahashi, Toshihiro Hashimoto, Yoshiaki Noma, Yoshinori Asakawa   +3 more
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6-Shogaol, a ginger product, modulates neuroinflammation: A new approach to neuroprotection

Neuropharmacology, 2012
Inflammatory processes in the central nervous system play an important role in a number of neurodegenerative diseases mediated by microglial activation, which results in neuronal cell death. Microglia act in immune surveillance and host defense while resting.
Sang Keun, Ha, Eunjung, Moon, Mi Sun, Ju, Dong Hyun, Kim, Jong Hoon, Ryu, Myung Sook, Oh, Sun Yeou, Kim   +6 more
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