Results 181 to 190 of about 12,356 (219)

Human lymphocytes resistant to 6-thioguanine increase with age

Mechanisms of Ageing and Development, 1982
Using an autoradiographic technique we determined the number of circulating lymphocytes that were resistant to 6-thioguanine and which were presumably mutants at the hypoxanthine--guanine phosphoribosyl transferase locus. The number in normal individuals was found to increase exponentially with age.
A A, Morley, S, Cox, R, Holliday
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6-Thioguanine treatment of psoriasis: Experience in 81 patients

Journal of the American Academy of Dermatology, 1994
Despite recent innovations a considerable number of patients with psoriasis cannot be successfully treated by current therapies.Our purpose was to summarize our 18-year experience with the antimetabolite 6-thioguanine in the management of patients with psoriasis.We retrospectively studied 81 patients who were treated with 6-thioguanine.
H S, Zackheim, R G, Glogau, D A, Fisher, H I, Maibach   +3 more
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Tautomers of 6-thioguanine: structures and properties

The Journal of Physical Chemistry, 1993
The molecular geometries of four tautomers of 6-thioguanine (6TG) were studied using ab initio LCAO-MO method at the Hartree-Fock level. All considered species are minimum structures on the 3-21G ≡ 8 potential energy surface (PES) of 6TG as determined from harmonic vibrational frequencies calculations carried out at the same level.
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Pharmacokinetics of 6-Thioguanine in Patients With Inflammatory Bowel Disease

Therapeutic Drug Monitoring, 2006
6-Thioguanine (6-TG) seems to be an attractive alternative in both AZA- and 6-MP-intolerant and -resistant IBD populations. However, little is known of 6-TG pharmacokinetics, metabolite levels, and their correlation with drug efficacy and toxicity in IBD patients.
Derijks, Luc J. J., Gilissen, Lennard P. L., Engels, Leopold G. J. B., Bos, Laurens P., Bus, Paul J., Lohman, Joseph J. H. M., van Deventer, Sander J. H., Hommes, Daniel W., Hooymans, Piet M.   +8 more
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Treatment of myelodysplastic syndromes with low‐dose oral 6‐thioguanine

Medical and Pediatric Oncology, 1988
AbstractSeveral cytotoxic agents when used in vitro in very low concentrations have been shown to induce differentiation of leukemic cells. We treated 18 patients with myelodysplastic syndromes with low‐dose oral 6‐thioguanine (6‐TG; 20 to 60 mg daily). Four patients demonstrated significant improvement in peripheral blood counts.
T R, Spitzer, H M, Lazarus, E D, Crum, R, Weisman   +3 more
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Characterization of the DNA damage in 6-thioguanine-treated cells

Biochemical Pharmacology, 1990
6-Thioguanine (TG) incorporation into DNA has been associated with cytotoxicity and DNA damage in Chinese hamster ovary (CHO) and murine leukemia L1210 cells. According to alkaline elution analysis, single-strand breaks (SSB) occur in both cell types. DNA-protein and interstrand crosslinks are prominent features of TG effects in L1210, CEM, and HL-60 ...
B F, Pan, J A, Nelson
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Reversible Hepatic Veno-Occlusive Disease and 6-Thioguanine

Annals of Internal Medicine, 1982
Excerpt To the editor: We read with interest the article by Gill and associates (1). We report another case of reversible veno-occlusive disease of the liver caused by 6-thioguanine in a patient wi...
N. KRIVOY, R. RAZ, A. CARTER, G. ALROY
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6-thioguanine-buried alive?

Gastroenterology, 2004
Klaus R. Herrlinger, Matthias Schwab, Klaus Fellermann, Eduard F. Stange   +3 more
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The Synthesis of 6-Thioguanine

Journal of the American Chemical Society, 1955
Gertrude B. Elion, George H. Hitchings
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Crystal and molecular structure of 6-thioguanine

Journal of the American Chemical Society, 1970
C E, Bugg, U, Thewalt
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