Results 171 to 180 of about 12,356 (219)

6-Methylthioguanylic acid, a metabolite of 6-thioguanine

Biochemical Pharmacology, 1971
Abstract Human epidermoid carcinoma (H. Ep. No. 2) cells, grown in culture in the presence of 6-thioguanine- 35 S or methionine[methyl- 14 C] plus unlabeled 6-thioguanine, contained a previously undescribed metabolite that was characterized by Chromatographic and electrophoretic migration and by chemical and enzymatic hydrolysis as 6 ...
P W, Allan, L L, Bennett
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Radiosensitization of two murine fibrosarcomas with 6-thioguanine

International Journal of Radiation Oncology*Biology*Physics, 1990
In Vivo murine tumor experiments were carried out to determine whether 6-thioguanine (6-TG) could enhance the cytotoxic effects of radiation on tumors. The combined effects of single and fractionated x-irradiation were evaluated on the transplanted methylcholanthrene induced fibrosarcoma (Meth-A) in BALB/c mice, a moderately radioresponsive tumor and ...
J H, Kim, A A, Alfieri, S H, Kim, S S, Hong   +3 more
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Enhancement of 6-thioguanine cytotoxic activity with methotrexate

Biochemical and Biophysical Research Communications, 1982
Abstract Studies were completed to characterize the cytotoxic and biochemical interaction of methotrexate (MTX) and 6-thioguanine (6-TG). Pretreatment of L1210 leukemia cells for 3 hr with MTX substantially enhanced the cytotoxicity of 6-TG. The LD90 of 6-TG in cells pretreated with 1μM MTX was 0.9pM, compared to an LD90 of 800 pM when the two drugs ...
R D, Armstrong, R, Vera, P, Snyder, E, Cadman   +3 more
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6-Thioguanine: High-dose 2-H infusions in goats

Journal of Cancer Research and Clinical Oncology, 1985
6-Thioguanine (6TG) is poorly absorbed after oral administration. Bolus injections of 6TG result in high peak concentrations with relatively short-lived plasma concentrations. In vitro studies have shown the importance of prolonged exposure to 6TG. Therefore we administered 6TG by infusion at a dose rate of 2 mg/h over 2 h. In three goats we determined
T J, Schouten, R A, De Abreu, E D, Schretlen, M B, van Leeuwen, J M, van Baal, G A, de Vaan   +5 more
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Spectrofluorometric determination of thiopurines—I 6-Thioguanine

Talanta, 1976
6-Thioguanine is oxidized to the corresponding S-oxide by reaction with hydrogen peroxide in 50% acetic acid at 50 degrees for 5 min. The S-oxide is highly fluorescent and a rapid and sensitive fluorometric method of determination of thioguanine at the ng ml level in water and mug ml level in blood serum and urine has been developed on the basis of ...
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Surface Layers of 6-Thioguanine on the Mercury Electrode

Journal of Colloid and Interface Science, 2002
The adsorption behavior of 6-thioguanine (6TG) on a hanging mercury drop electrode has been studied with ac and cyclic voltammetry in 0.1 M Na2SO4 and 0.01 M sodium acetate solutions at pH 4.3. Several condensed phases of chemically adsorbed 6TG as well as one phase of physically adsorbed 6TG have been characterized.
Zoraida González, Arias, Jesús Luis Muñiz, Alvarez, Juan Miguel López, Fonseca   +2 more
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6 thioguanine sensing using poly pyrrole: DFT study

AIP Conference Proceedings, 2021
The conducting polymers (CPs) are the important materials due to their large surface area, high thermal stability, good conductivity, easy to shape, process and their properties can be tuned by modifying their structures or processing. Few polymers have emerged as potential candidate for the determination of a few anti-cancer drugs.
Kirtesh Pratap Khare, Rachana Kathal, Neelima Shukla, Reena Srivastava, Anurag Srivastava   +4 more
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D.A.T. (DAUNORUBICIN, CYTARABINE, 6-THIOGUANINE) IN ACUTE MYELOID LEUKÆMIA

Lancet, The, 1978
J K, Rees, F G, Hayhoe
exaly   +3 more sources

ChemInform Abstract: OPTIMIZATION OF 6‐THIOGUANINE PRODUCTION

Chemischer Informationsdienst, 1985
AbstractDas bekannte Verfahren zur Herstellung von 6‐Thioguanin (III) aus Guanin (II) mit P4810 in Pyridin ergibt Ausbeuten nur bis 25 %.
U. A. TOMSONS, A. A. AVOTS, I. A. KOLESNIKOVA   +2 more
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Hepatotoxicity Associated With 6-Thioguanine Therapy for Crohn's Disease

Journal of Clinical Gastroenterology, 2003
6-Thioguanine (6-TG) is a thiopurine analogue that is closely related to 6-mercaptopurine (6-MP) and azathioprine (AZA). These agents have potent cytotoxic and immunomodulatory effects and are useful in the treatment of a variety of conditions, including inflammatory bowel disease. Both 6-MP and AZA are widely used and are known to cause hepatotoxicity
Stephen J, Rulyak, Michael D, Saunders, Scott D, Lee   +2 more
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